Jocelyn Rivera

US Patent:

7119200, Oct 10, 2006

Filed:

Feb 11, 2004

Appl. No.:

10/776988

Inventors:

Timothy J. Guzi - Chatham NJ, US
Kamil Paruch - Garwood NJ, US
Michael P. Dwyer - Scotch Plains NJ, US
Ronald J. Doll - Convent Station NJ, US
Viyyoor M. Girijavallabhan - Parsippany NJ, US
Alan Mallams - Hackettstown NJ, US
Carmen S. Alvarez - Livingston NJ, US
Kartik M. Keertikar - East Windsor NJ, US
Jocelyn Rivera - Monmouth Junction NJ, US
Tin-Yau Chan - Edison NJ, US
Vincent Madison - Mountain Lakes NJ, US
Thierry O. Fischmann - Scotch Plains NJ, US
Lawrence W. Dillard - Skillman NJ, US
Vinh D. Tran - Fountain Valley CA, US
Zhen Min He - Princeton NJ, US
Ray Anthony James - Bristol PA, US
Haengsoon Park - Plainsboro NJ, US
Vidyadhar M. Hobbs - Somerville NJ, US
Douglas Walsh Hobbs - Yardley PA, US

Assignee:

Schering Corporation - Kenilworth NJ
Pharmacopeia Drug Discovery, Inc. - Cranbury NJ

International Classification:

C07D 487/04

US Classification:

544281

Abstract:

In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.

US Patent:

7138396, Nov 21, 2006

Filed:

Jan 28, 2005

Appl. No.:

11/045967

Inventors:

Timothy J. Guzi - Chatham NJ, US
Kamil Paruch - Garwood NJ, US
Alan K. Mallams - Hackettstown NJ, US
Jocelyn D. Rivera - Monmouth Junction NJ, US
Ronald J. Doll - Convent Station NJ, US
Viyyoor M. Girijavallabhan - Parsippany NJ, US
Jonathan A. Pachter - Chatham NJ, US
Yi-Tsung Liu - Morris Township NJ, US
Anil K. Saksena - Upper Montclair NJ, US

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

A61K 31/497

US Classification:

51425211, 51425301, 51425313

Abstract:

There are disclosed compounds of the formula (I):.

US Patent:

7161003, Jan 9, 2007

Filed:

Sep 3, 2003

Appl. No.:

10/654546

Inventors:

Timothy J. Guzi - Chatham NJ, US
Kamil Paruch - Garwood NJ, US
Michael P. Dwyer - Scotch Plains NJ, US
Ronald J. Doll - Convent Station NJ, US
Viyyoor M. Girijavallabhan - Parsippany NJ, US
Alan Mallams - Hackettstown NJ, US
Carmen S. Alvarez - Livingston NJ, US
Kartik M. Keertikar - East Windsor NJ, US
Jocelyn Rivera - Monmouth Junction NJ, US
Tin-Yau Chan - Edison NJ, US
Vincent Madison - Mountain Lakes NJ, US
Thierry O. Fischmann - Scotch Plains NJ, US
Lawrence W. Dillard - Skillman NJ, US
Vinh D. Tran - Fountain Valley NJ, US
Zhen Min He - Princeton NJ, US
Ray Anthony James - Bristol PA, US
Haengsoon Park - Plainsboro NJ, US
Vidyadhar M. Paradkar - Somerville NJ, US
Douglas Walsh Hobbs - Yardley PA, US

Assignee:

Schering Corporation - Kenilworth NJ
Pharmacopeia Drug Discovery, Inc. - Cranbury NJ

International Classification:

C07D 487/04

US Classification:

544281

Abstract:

In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.

US Patent:

7432268, Oct 7, 2008

Filed:

Nov 14, 2005

Appl. No.:

11/273712

Inventors:

Timothy Guzi - Chatham NJ, US
Kamil Paruch - Garwood NJ, US
Alan Mallams - Hackettstown NJ, US
Jocelyn D. Rivera - Monmouth Junction NJ, US
Ronald J. Doll - Convent Station NJ, US
Viyyoor M. Girijavallabhan - Parsippany NJ, US
Jonathan A. Pachter - Chatham NJ, US
Yi-Tsung Liu - Morris Township NJ, US
Anil K. Saksena - Upper Montclair NJ, US

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

A61K 31/497
A61K 31/445
A01N 43/40
C07D 241/02
C07D 211/70
C07D 211/82
C07D 213/06

US Classification:

51425211, 51425313, 514316, 544357, 544365, 546349

Abstract:

There are disclosed compounds of the formula (I):.

US Patent:

7807683, Oct 5, 2010

Filed:

Mar 31, 2006

Appl. No.:

11/396001

Inventors:

Timothy J. Guzi - Chatham NJ, US
Kamil Paruch - Garwood NJ, US
Michael P. Dwyer - Scotch Plains NJ, US
Ronald J. Doll - Convent Station NJ, US
Viyyoor M. Girijavallabhan - Parsippany NJ, US
Alan Mallams - Hackettstown NJ, US
Carmen S. Alvarez - Livingston NJ, US
Kartik M. Keertikar - East Windsor NJ, US
Jocelyn Rivera - Monmouth Junction NJ, US
Tin Yau Chan - Edison NJ, US
Vincent Madison - Mountain Lakes NJ, US
Thierry O. Fischmann - Scotch Plains NJ, US
Lawrence W. Dillard - Skillman NJ, US
Vinh D. Tran - Fountain Valley CA, US
Zhen Min He - Princeton NJ, US
Ray Anthony James - Bensalem PA, US
Haengsoon Park - Plainsboro NJ, US
Vidyadhar M. Paradkar - Somerville NJ, US
Douglas Walsh Hobbs - Yardley PA, US

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

A61K 31/519
A61P 35/04
A61P 35/02
C07D 487/04
A61P 35/00

US Classification:

5142593, 544281, 51426332, 51425217, 514183, 514 81, 514110, 5142342, 51425216, 514151, 514 8, 514 9, 514 27, 514167, 514 15, 514221, 514245, 424649, 424 944

Abstract:

In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.

US Patent:

20040132736, Jul 8, 2004

Filed:

Sep 5, 2002

Appl. No.:

10/235627

Inventors:

Timothy Guzi - Chatham NJ, US
Kamil Paruch - Cranford NJ, US
Alan Mallams - Mallams NJ, US
Jocelyn Rivera - Monmouth Junction NJ, US
Ronald Doll - Convent Station NJ, US
Viyyoor Girijavallabhan - Parsippany NJ, US
Jonathan Pachter - Maplewood NJ, US
Yi-Tsung Liu - Morris Township NJ, US
Anil Saksena - Upper Montclair NJ, US

Assignee:

Schering Corporation

International Classification:

C07D413/14
C 07D 4 3/14
C 07D 4 3/02
C 07D 4 1/02
A61K031/496
A61K031/4545
C 07D 4 1/14

US Classification:

514/252110, 514/253130, 514/316000, 544/360000, 544/357000, 546/187000, 546/189000

Abstract:

There are disclosed compounds of the formula (I): prodrugs thereof, or pharmaceutically acceptable salts of the compounds or of said prodrugs which are useful as inhibitors of Type 3 17 -Hydroxysteroid Dehydrogenase. Also disclosed are pharmaceutical compositions containing said compounds and their use for the treatment or prevention of androgen dependent diseases.

US Patent:

20070054925, Mar 8, 2007

Filed:

Mar 31, 2006

Appl. No.:

11/396079

Inventors:

Timothy Guzi - Chatham NJ, US
Kamil Paruch - Garwood NJ, US
Michael Dwyer - Scotch Plains NJ, US
Ronald Doll - Convent Station NJ, US
Viyyoor Girijavallabhan - Parsippany NJ, US
Alan Mallams - Hackettstown NJ, US
Carmen Alvarez - Livingston NJ, US
Kartik Keertikar - East Windsor NJ, US
Jocelyn Rivera - Monmouth Junction NJ, US
Tin-Yau Chan - Edison NJ, US
Vincent Madison - Mountain Lakes NJ, US
Thierry Fischmann - Scotch Plains NJ, US
Lawrence Dillard - Skillman NJ, US
Vinh Tran - Fountain Valley CA, US
Zhen He - Princeton NJ, US
Ray James - Bensalem PA, US
Haengsoon Park - Plainsboro NJ, US
Vidyadhar Paradkar - Somerville NJ, US
Douglas Hobbs - Yardley PA, US

International Classification:

A61K 31/519
C07D 487/04

US Classification:

514259300, 544281000

Abstract:

In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.

US Patent:

20080050384, Feb 28, 2008

Filed:

Apr 20, 2007

Appl. No.:

11/788847

Inventors:

Timothy Guzi - Chatham NJ, US
Kamil Paruch - Garwood NJ, US
Michael Dwyer - Scotch Plains NJ, US
Ronald Doll - Convent Station NJ, US
Viyyoor Girijavallabhan - Parsippany NJ, US
Alan Mallams - Hackettstown NJ, US
Carmen Alvarez - Livingston NJ, US
Kartik Keertikar - East Windsor NJ, US
Jocelyn Rivera - Monmouth Junction NJ, US
Tin-Yau Chan - Edison NJ, US
Vincent Madison - Mountain Lakes NJ, US
Thierry Fischmann - Scotch Plains NJ, US
Lawrence Dillard - Skillman NJ, US
Vinh Tran - Fountain Valley CA, US
Zhenmin He - Shanghai, CN
Ray James - Bensalem PA, US
Haengsoon Park - Plainsboro NJ, US
Vidyadhar Paradkar - Somerville NJ, US
Douglas Hobbs - Yardley PA, US
Paul Kirschmeier - Basking Ridge NJ, US
Rajat Bannerji - Morristown NJ, US

International Classification:

A61K 31/519
A61K 31/33
A61K 31/4965
A61K 31/56
A61K 31/675
A61K 33/24
A61K 38/46
A61P 19/02
A61P 35/00
A61P 43/00
A61P 29/00
A61K 39/395
A61K 33/36
A61K 31/7004
A61K 31/655
A61K 31/535
A61K 31/497

US Classification:

424141100, 424130100, 424623000, 424649000, 424094600, 514151000, 514177000, 514178000, 514180000, 514182000, 514183000, 514234500, 514252120, 514255050, 514255060, 514259300, 514048000, 514049000, 514090000

Abstract:

In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.