Jinjun Y Shi

US Patent:

8277812, Oct 2, 2012

Filed:

Apr 22, 2009

Appl. No.:

12/428408

Inventors:

Matteo Iannacone - Boston MA, US
Frank Alexis - Brighton MA, US
Pamela Basto - Somerville MA, US
Elliott Ashley Moseman - Jamaica Plain MA, US
Jinjun Shi - Boston MA, US
Robert S. Langer - Newton MA, US
Omid C. Farokhzad - Chestnut Hill MA, US
Ulrich von Andrian - Chestnut Hill MA, US
Elena Tonti - Riccione, IT

Assignee:

Massachusetts Institute of Technology - Cambridge MA
President and Fellows of Harvard College - Cambridge MA
The Brigham and Women's Hospital, Inc. - Boston MA

International Classification:

A61K 39/395

US Classification:

4241841, 4241931

Abstract:

The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides synthetic nanocarriers capable of eliciting an immune system response in the form of antibody production, wherein the nanocarriers lack any T cell antigens. In some embodiments, the invention provides nanocarriers that comprise an immunofeature surface, which provides high avidity binding of the nanocarriers to antigen presenting cells. The invention provides pharmaceutical compositions comprising inventive nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive nanocarriers and pharmaceutical compositions thereof.

US Patent:

8343497, Jan 1, 2013

Filed:

Apr 22, 2009

Appl. No.:

12/428381

Inventors:

Jinjun Shi - Boston MA, US
Frank Alexis - Greenville SC, US
Matteo Iannacone - Boston MA, US
Elliott Ashley Moseman - Jamaica Plain MA, US
Pamela Basto - Somerville MA, US
Robert S. Langer - Newton MA, US
Omid C. Farokhzad - Chestnut Hill MA, US
Ulrich von Andrian - Chestnut Hill MA, US
Elena Tonti - Riccione, IT

Assignee:

The Brigham and Women's Hospital, Inc. - Boston MA
President and Fellows of Harvard College - Cambridge MA
Massachusetts Institute of Technology - Cambridge MA

International Classification:

A61K 39/00
A61K 47/00

US Classification:

4241841, 4242781

Abstract:

The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface. The nanocarriers are capable of targeting antigen presenting cells when administered to a subject. The invention provides pharmaceutical compositions comprising inventive nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive nanocarriers and pharmaceutical compositions thereof.

US Patent:

8343498, Jan 1, 2013

Filed:

Apr 22, 2009

Appl. No.:

12/428395

Inventors:

Frank Alexis - Greenville SC, US
Matteo Iannacone - Boston MA, US
Jinjun Shi - Boston MA, US
Pamela Basto - Somerville MA, US
Elliott Ashley Moseman - Jamaica Plain MA, US
Ulrich von Andrian - Chestnut Hill MA, US
Robert S. Langer - Newton MA, US
Omid C. Farokhzad - Chestnut Hill MA, US
Elena Tonti - Riccione, IT

Assignee:

Massachusetts Institute of Technology - Cambridge MA
The Brigham and Women's Hospital, Inc. - Boston MA
President and Fellows of Harvard College - Cambridge MA

International Classification:

A61K 39/00
A61K 47/00

US Classification:

4241841, 4242781

Abstract:

The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface and an immunostimulatory moiety. In some embodiments, the immunostimulatory moiety is an adjuvant. The invention provides pharmaceutical compositions comprising inventive nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive nanocarriers and pharmaceutical compositions thereof.

US Patent:

8562998, Oct 22, 2013

Filed:

Oct 9, 2009

Appl. No.:

13/123884

Inventors:

Jinjun Shi - Boston MA, US
Frank Alexis - Greenville SC, US
Matteo Iannacone - Boston MA, US
Elliott Ashley Moseman - Jamaica Plain MA, US
Pamela Basto - Somerville MA, US
Robert S. Langer - Newton MA, US
Omid C. Farokhzad - Chestnut Hill MA, US
Ulrich von Andrian - Chestnut Hill MA, US
Elena Tonti - Riccione, IT

Assignee:

President and Fellows of Harvard College - Cambridge MA
Massachusetts Institute of Technology - Cambridge MA
The Brigham and Women's Hospital, Inc. - Boston MA

International Classification:

A61K 39/00
A61K 47/00

US Classification:

4241841, 4242781

Abstract:

The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface. The nanocarriers are capable of targeting antigen presenting cells when administered to a subject. The invention provides pharmaceutical compositions comprising nanocarriers. The present invention provides methods of designing, manufacturing, and using nanocarriers and pharmaceutical compositions thereof.

US Patent:

8591905, Nov 26, 2013

Filed:

Apr 22, 2009

Appl. No.:

12/428388

Inventors:

Ulrich von Andrian - Chestnut Hill MA, US
Omid C. Farokhzad - Chestnut Hill MA, US
Frank Alexis - Greenville SC, US
Matteo Iannacone - Boston MA, US
Pamela Basto - Somerville MA, US
Jinjun Shi - Boston MA, US
Elliott Ashley Moseman - Jamaica Plain MA, US
Robert S. Langer - Newton MA, US
Elena Tonti - Riccione, IT

Assignee:

The Brigham and Women's Hospital, Inc. - Boston MA
President and Fellows of Harvard College - Cambridge MA
Massachusetts Institute of Technology - Cambridge MA

International Classification:

A61K 39/00
A61K 47/00

US Classification:

4241841, 4242781

Abstract:

The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface having a plurality of nicotine moieties. The invention provides pharmaceutical compositions comprising inventive nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive nanocarriers and pharmaceutical compositions thereof. For example, the present invention nanocarriers capable of eliciting an immune response and the production of anti-nicotine antibodies.

US Patent:

8637028, Jan 28, 2014

Filed:

Oct 9, 2009

Appl. No.:

13/123888

Inventors:

Frank Alexis - Greenville SC, US
Matteo Iannacone - Milan, IT
Jinjun Shi - Boston MA, US
Pamela Basto - Boston MA, US
Elliott Ashley Moseman - Jamaica Plain MA, US
Ulrich von Andrian - Chestnut Hill MA, US
Robert S. Langer - Newton MA, US
Omid C. Farokhzad - Waban MA, US
Elena Tonti - Riccione, IT

Assignee:

President and Fellows of Harvard College - Cambridge MA
Massachusetts Institute of Technology - Cambridge MA
The Brigham and Women's Hospital - Boston MA

International Classification:

A61K 39/40
A61K 39/395
A61K 49/04

US Classification:

4241431, 424 9321, 424 9322, 424 934, 4241301, 4241341, 4241531, 4241541, 4241781, 4241851, 4242781

Abstract:

The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface and an immunostimulatory moiety. In some embodiments, the immunostimulatory moiety is an adjuvant. The invention provides pharmaceutical compositions comprising inventive nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive nanocarriers and pharmaceutical compositions thereof.

US Patent:

20120087890, Apr 12, 2012

Filed:

Oct 9, 2009

Appl. No.:

13/123887

Inventors:

Matteo Iannacone - Boston MA, US
Frank Alexis - Greenville SC, US
Pamela Basto - Somerville MA, US
Elliott Ashley Moseman - Jamaica Plain MA, US
Jinjun Shi - Boston MA, US
Robert S. Langer - Newton MA, US
Omid C. Farokhzad - Chestnut Hill MA, US
Ulrich von Andrian - Chestnut Hill MA, US
Elena Tonti - Riccione, IT

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

A61K 38/20
A61K 39/00
A61P 37/04
A61K 38/21

US Classification:

424 852, 424 854, 4241841

Abstract:

The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides synthetic nanocarriers capable of eliciting an immune system response in the form of antibody production, wherein the nanocarriers lack any T cell antigens. In some embodiments, the invention provides nanocarriers that comprise an immunofeature surface, which provides high avidity binding of the nanocarriers to antigen presenting cells. The invention provides pharmaceutical compositions comprising such nanocarriers. The present invention provides methods of designing, manufacturing maceutical compositions thereof.

US Patent:

20130129790, May 23, 2013

Filed:

Oct 12, 2012

Appl. No.:

13/651124

Inventors:

Frank Alexis - Greenville SC, US
Matteo Iannacone - Milano, IT
Jinjun Shi - Boston MA, US
Pamela Basto - Cambridge MA, US
Elliott Ashley Moseman - Jamaica Plain MA, US
Ulrich Von Andrian - Chestnut Hill MA, US
Robert S. Langer - Newton MA, US
Omid C. Farokhzad - Waban MA, US
Elena Tonti - Riccione, IT

International Classification:

A61K 39/39
A61K 45/06

US Classification:

424400, 4241841, 424 852, 424 854, 4242391, 4242381

Abstract:

The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface and an immunostimulatory moiety. In some embodiments, the immunostimulatory moiety is an adjuvant. The invention provides pharmaceutical compositions comprising inventive nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive nanocarriers and pharmaceutical compositions thereof.