Jinjun Y Shi

US Patent:

8277812, Oct 2, 2012

Filed:

Apr 22, 2009

Appl. No.:

12/428408

Inventors:

Matteo Iannacone - Boston MA, US
Frank Alexis - Brighton MA, US
Pamela Basto - Somerville MA, US
Elliott Ashley Moseman - Jamaica Plain MA, US
Jinjun Shi - Boston MA, US
Robert S. Langer - Newton MA, US
Omid C. Farokhzad - Chestnut Hill MA, US
Ulrich von Andrian - Chestnut Hill MA, US
Elena Tonti - Riccione, IT

Assignee:

Massachusetts Institute of Technology - Cambridge MA
President and Fellows of Harvard College - Cambridge MA
The Brigham and Women's Hospital, Inc. - Boston MA

International Classification:

A61K 39/395

US Classification:

4241841, 4241931

Abstract:

The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides synthetic nanocarriers capable of eliciting an immune system response in the form of antibody production, wherein the nanocarriers lack any T cell antigens. In some embodiments, the invention provides nanocarriers that comprise an immunofeature surface, which provides high avidity binding of the nanocarriers to antigen presenting cells. The invention provides pharmaceutical compositions comprising inventive nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive nanocarriers and pharmaceutical compositions thereof.

US Patent:

8343497, Jan 1, 2013

Filed:

Apr 22, 2009

Appl. No.:

12/428381

Inventors:

Jinjun Shi - Boston MA, US
Frank Alexis - Greenville SC, US
Matteo Iannacone - Boston MA, US
Elliott Ashley Moseman - Jamaica Plain MA, US
Pamela Basto - Somerville MA, US
Robert S. Langer - Newton MA, US
Omid C. Farokhzad - Chestnut Hill MA, US
Ulrich von Andrian - Chestnut Hill MA, US
Elena Tonti - Riccione, IT

Assignee:

The Brigham and Women's Hospital, Inc. - Boston MA
President and Fellows of Harvard College - Cambridge MA
Massachusetts Institute of Technology - Cambridge MA

International Classification:

A61K 39/00
A61K 47/00

US Classification:

4241841, 4242781

Abstract:

The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface. The nanocarriers are capable of targeting antigen presenting cells when administered to a subject. The invention provides pharmaceutical compositions comprising inventive nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive nanocarriers and pharmaceutical compositions thereof.

US Patent:

8562998, Oct 22, 2013

Filed:

Oct 9, 2009

Appl. No.:

13/123884

Inventors:

Jinjun Shi - Boston MA, US
Frank Alexis - Greenville SC, US
Matteo Iannacone - Boston MA, US
Elliott Ashley Moseman - Jamaica Plain MA, US
Pamela Basto - Somerville MA, US
Robert S. Langer - Newton MA, US
Omid C. Farokhzad - Chestnut Hill MA, US
Ulrich von Andrian - Chestnut Hill MA, US
Elena Tonti - Riccione, IT

Assignee:

President and Fellows of Harvard College - Cambridge MA
Massachusetts Institute of Technology - Cambridge MA
The Brigham and Women's Hospital, Inc. - Boston MA

International Classification:

A61K 39/00
A61K 47/00

US Classification:

4241841, 4242781

Abstract:

The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface. The nanocarriers are capable of targeting antigen presenting cells when administered to a subject. The invention provides pharmaceutical compositions comprising nanocarriers. The present invention provides methods of designing, manufacturing, and using nanocarriers and pharmaceutical compositions thereof.

US Patent:

8591905, Nov 26, 2013

Filed:

Apr 22, 2009

Appl. No.:

12/428388

Inventors:

Ulrich von Andrian - Chestnut Hill MA, US
Omid C. Farokhzad - Chestnut Hill MA, US
Frank Alexis - Greenville SC, US
Matteo Iannacone - Boston MA, US
Pamela Basto - Somerville MA, US
Jinjun Shi - Boston MA, US
Elliott Ashley Moseman - Jamaica Plain MA, US
Robert S. Langer - Newton MA, US
Elena Tonti - Riccione, IT

Assignee:

The Brigham and Women's Hospital, Inc. - Boston MA
President and Fellows of Harvard College - Cambridge MA
Massachusetts Institute of Technology - Cambridge MA

International Classification:

A61K 39/00
A61K 47/00

US Classification:

4241841, 4242781

Abstract:

The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface having a plurality of nicotine moieties. The invention provides pharmaceutical compositions comprising inventive nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive nanocarriers and pharmaceutical compositions thereof. For example, the present invention nanocarriers capable of eliciting an immune response and the production of anti-nicotine antibodies.

US Patent:

20120087890, Apr 12, 2012

Filed:

Oct 9, 2009

Appl. No.:

13/123887

Inventors:

Matteo Iannacone - Boston MA, US
Frank Alexis - Greenville SC, US
Pamela Basto - Somerville MA, US
Elliott Ashley Moseman - Jamaica Plain MA, US
Jinjun Shi - Boston MA, US
Robert S. Langer - Newton MA, US
Omid C. Farokhzad - Chestnut Hill MA, US
Ulrich von Andrian - Chestnut Hill MA, US
Elena Tonti - Riccione, IT

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

A61K 38/20
A61K 39/00
A61P 37/04
A61K 38/21

US Classification:

424 852, 424 854, 4241841

Abstract:

The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides synthetic nanocarriers capable of eliciting an immune system response in the form of antibody production, wherein the nanocarriers lack any T cell antigens. In some embodiments, the invention provides nanocarriers that comprise an immunofeature surface, which provides high avidity binding of the nanocarriers to antigen presenting cells. The invention provides pharmaceutical compositions comprising such nanocarriers. The present invention provides methods of designing, manufacturing maceutical compositions thereof.

US Patent:

20130315831, Nov 28, 2013

Filed:

Sep 2, 2011

Appl. No.:

13/820351

Inventors:

Jinjun Shi - Boston MA, US
Zeyu Xiao - Boston MA, US
Cristian Vilos - Newton MA, US
Alexander Votruba - Boston MA, US
Robert S. Langer - Newton MA, US
Omid C. Farokhzad - Chestnut Hill MA, US

Assignee:

MASSACHUSETTS INSTITUTE OF TECHNOLOGY - Cambridge MA
THE BRIGHAM AND WOMEN'S HOSPITAL, INC. - Boston MA

International Classification:

A61K 9/50
A61K 49/00
A61K 31/337
A61K 31/713
A61K 31/704

US Classification:

424 91, 424497, 424498, 514 44 A, 514 34, 514449, 4241841

Abstract:

A particle includes an aqueous core; a first amphiphilic layer surrounding the aqueous core; and a polymeric matrix surrounding the first amphiphilic layer.

US Patent:

20220226510, Jul 21, 2022

Filed:

Jan 26, 2022

Appl. No.:

17/585118

Inventors:

- Boston MA, US
Jinjun Shi - Boston MA, US
Omid C. Farokhzad - Boston MA, US

International Classification:

A61K 49/00
A61K 9/51
C08F 293/00
A61K 9/127
A61K 47/65

Abstract:

Stimuli-responsive NPs with excellent stability, high loading efficiency, encapsulation of multiple agents, targeting to certain cells, tissues or organs of the body, can be used as delivery tools. These NPs contain a hydrophobic inner core and hydrophilic outer shell, which endows them with high stability and the ability to load therapeutic agents with high encapsulation efficiency. The NPs are preferably formed from amphiphilic stimulus-responsive polymers or a mixture of amphiphilic and hydrophobic polymers or compounds, at least one type of which is stimuli-responsive. These NPs can be made so that their cargo is released primarily within target certain cells, tissues or organs of the body, upon exposure to endogenous or exogenous stimuli. The rate of release can be controlled so that it may be a burst, sustained, delayed, or a combination thereof. The NPs have utility as research tools or for clinical applications including diagnostics, therapeutics, or combination of both.

US Patent:

20210299060, Sep 30, 2021

Filed:

Jul 8, 2020

Appl. No.:

16/923938

Inventors:

- Boston MA, US
Xiaoding Xu - Malden MA, US
Jinjun Shi - Newton MA, US

International Classification:

A61K 9/51
A61K 47/62
A61K 47/60
A61K 47/69
A61P 35/00
A61K 31/7088
A61K 38/46
A61K 45/06
A61K 48/00
C12N 15/113

Abstract:

Nanoparticulate pharmaceutical formulations and methods for co-delivery of two or more species of nucleic acids for simultaneous suppression and expression of target genes in a cell, are provided. The nanoparticles encapsulate two or more nucleic acid species. The first nucleic acid suppresses expression of a gene or product thereof, e.g., inhibitory nucleic acid, such as antisense, siRNA, miRNA, Dicer siRNA, piRNA, etc. The second nucleic acid increases expression of, or encodes, an endogenous or exogenous protein or polypeptide, e.g., an mRNA. The first and second nucleic acid species simultaneously target or affect the same or different cellular processes within a cell including communication, senescence, DNA repair, gene expression, metabolism, necrosis, and apoptosis.