Jingrong R Cao from 32 Leonard Ave, Newton, MA 02465, age 57, Phone: 617 515-9346

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Ring Opening Metathesis Of Alkenes
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US Patent:

6486324, Nov 26, 2002
Filed:

Jan 23, 2001
Appl. No.:

09/767376
Inventors:

Gregory D. Cuny - Hudson MA
Jingrong Cao - Shrewsbury MA
James R. Hauske - Hopkinton MA
Assignee:

Sepracor Inc. - Marlborough MA
International Classification:

C07D22104
US Classification:

546183, 546112
Abstract:

Methods for performing ring-opening cross-metathesis reactions on solid support are disclosed. Substituted cyclic compounds, libraries of the compounds, and methods of using the compounds to treat bacterial infections are also disclosed.

Isoxazole Compositions Useful As Inhibitors Of Erk
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US Patent:

6495582, Dec 17, 2002
Filed:

Sep 14, 2001
Appl. No.:

09/953120
Inventors:

Michael Hale - Bedford MA
James Janetka - Beverly MA
Francois Maltais - Tewksbury MA
Jingrong Cao - West Newton MA
Robert Mashal - West Newton MA
Assignee:

Vertex Pharmaceuticals Incorporated - Cambridge MA
International Classification:

C07D41304
US Classification:

514378, 548247
Abstract:

Described herein are compounds that are useful as protein kinase inhibitors, especially inhibitors of ERK, having the formula: where A, B, R , R , T and Ht are described in the specification. The compounds are useful for treating diseases in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, and cardiovascular disease.

Pyrazole Compositions Useful As Inhibitors Of Erk
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US Patent:

6528509, Mar 4, 2003
Filed:

Oct 5, 2001
Appl. No.:

09/972437
Inventors:

Michael Hale - Bedford MA
Xiaoling Xie - Cambridge MA
Jeremy Green - Burlington MA
Jingrong Cao - Newton MA
Christopher Baker - Bedford MA
Francois Maltais - Somerville MA
James Janetka - Beverly MA
Guy Bemis - Arlington MA
Michael Mullican - Needham MA
Judith Straub - Cambridge MA
Qing Tang - Cambridge MA
Robert Mashal - West Newton MA
Assignee:

Vertex Pharmacuticals, Incorporated - Cambridge MA
International Classification:

A61K 315377
US Classification:

5142365, 540575, 544140, 544295, 544328, 544367, 544371, 544363, 546 86, 546146, 546199, 5462737, 5462754, 546211, 548127, 5483124, 5483641, 5483644, 5483657
Abstract:

Described herein are compounds that are useful as protein kinase inhibitors having the formula: where R , Q, and T are described in the specification. The compounds are useful for treating disease states in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, and cardiovascular disease.

Pyrazole Compositions Useful As Inhibitors Of Erk
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US Patent:

6593357, Jul 15, 2003
Filed:

Aug 22, 2002
Appl. No.:

10/225719
Inventors:

Jeremy Green - Burlington MA
Jingrong Cao - Newton MA
Michael Hale - Bedford MA
Christopher Baker - Bedford MA
Francois Maltais - Somerville MA
James Janetka - Beverly MA
Michael Mullican - Needham MA
Guy Bemis - Arlington MA
Xiaoling Xie - Cambridge MA
Judith Straub - Cambridge MA
Qing Tang - Cambridge MA
Assignee:

Vertex Pharmaceuticals Incorporated - Cambridge MA
International Classification:

A61K 314155
US Classification:

514406, 544328, 5462754, 546211, 5483641, 5483644, 5483657, 548127, 5483117, 5483127
Abstract:

Described herein are compounds that are useful as protein kinase inhibitors having the formula: where R , Q, and T are described in the specification. The compounds are useful for treating disease states in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, and cardiovascular disease.

Inhibitors Of C-Jun N-Terminal Kinases (Jnk) And Other Protein Kinases
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US Patent:

6642227, Nov 4, 2003
Filed:

Apr 10, 2002
Appl. No.:

10/121035
Inventors:

Jingrong Cao - Newton MA
Jeremy Green - Burlington MA
Young-Choon Moon - Lexington MA
Jian Wang - Boston MA
Mark Ledeboer - Acton MA
Edmund Harrington - South Boston MA
Huai Gao - Natick MA
Assignee:

Vertex Pharmaceuticals Incorporated - Cambridge MA
International Classification:

C07D40904
US Classification:

5142278, 5142358, 51425219, 514275, 544 60, 544122, 544331
Abstract:

The present invention provides compounds of formula I: or a pharmaceutically acceptable derivative o thereof, wherein A, B, R , R , R , R , and R are as described in the specification. These compounds are inhibitors of protein kinase, particularly inhibitors of JNK, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli; Lck and Src kinase. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.

Isoxazole Compositions Useful As Inhibitors Of Erk
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US Patent:

6649640, Nov 18, 2003
Filed:

Oct 15, 2002
Appl. No.:

10/272622
Inventors:

Michael Hale - Bedford MA
James Janetka - Beverly MA
Francois Maltais - Somerville MA
Jingrong Cao - West Newton MA
Assignee:

Vertex Pharmaceuticals Incorporated - Cambridge MA
International Classification:

A61K 31422
US Classification:

514378, 548247
Abstract:

Described herein are compounds that are useful as protein kinase inhibitors, especially inhibitors of ERK, having the formula: where A, B, R , R , T and Ht are described in the specification. The compounds are useful for treating diseases in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, and cardiovascular disease.

Inhibitors Of C-Jun N Terminal Kinases (Jnk) And Other Protein Kinases
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US Patent:

6693108, Feb 17, 2004
Filed:

Feb 12, 2002
Appl. No.:

10/074177
Inventors:

Jeremy Green - Burlington MA
Guy Bemis - Arlington MA
Anne-Laure Grillot - Cambridge MA
Mark Ledeboer - Acton MA
Francesco G. Salituro - Marlboro MA
Edmund Harrington - South Boston MA
Huai Gao - Natick MA
Christopher Baker - Bedford MA
Jingrong Cao - Newton MA
Michael Hale - Bedford MA
Assignee:

Vertex Pharmaceuticals Incorporated - Cambridge MA
International Classification:

C07D40104
US Classification:

514275, 544331
Abstract:

The present invention provides compounds of formula I: where R is H, CONH , T âR, or T âAr , n may be zero or one, and G, XYZ, and Q are as described below. These compounds are inhibitors of protein kinase, particularly inhibitors of JNK, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.

Pyrazole Compositions Useful As Inhibitors Of Erk
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US Patent:

6699865, Mar 2, 2004
Filed:

Jan 2, 2003
Appl. No.:

10/335793
Inventors:

Michael Hale - Bedford MA
Xiaoling Xie - Cambridge MA
Jeremy Green - Burlington MA
Jingrong Cao - Newton MA
Christopher Baker - Bedford MA
Francois Maltais - Somerville MA
James Janetka - Beverly MA
Guy Bemis - Arlington MA
Michael Mullican - Needham MA
Judith Straub - Cambridge MA
Qing Tang - Cambridge MA
Assignee:

Vertex Pharmaceuticals Incorporated - Cambridge MA
International Classification:

A61K 314155
US Classification:

5142365, 540575, 544140, 544295, 544363, 544371, 546146, 546199, 546211, 546 86, 5483641
Abstract:

Described herein are compounds that are useful as protein kinase inhibitors having the formula: where R , Q, and T are described in the specification. The compounds are useful for treating disease states in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, and cardiovascular disease.