Jing Fen Wen

US Patent:

20200323786, Oct 15, 2020

Filed:

May 24, 2017

Appl. No.:

16/304116

Inventors:

- Oakland CA, US
- Los Angeles CA, US
- Tianjin, CN
Juanjuan Du - San Diego CA, US
Jing Wen - Culver City CA, US
Yang Liu - Los Angeles CA, US
Xubo Yuan - Tianjin, CN

Assignee:

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA
THE UNIVERSITY OF SOUTHERN CALIFORNIA - Los Angeles CA
TIANJIN UNIVERSITY - Tianjin CA

International Classification:

A61K 9/51
A61K 38/18
B82Y 5/00
A61P 19/00

Abstract:

Growth factors are of great potential in regenerative medicine. However, their clinical applications are largely limited in by short in vivo half-lives and a narrow therapeutic window. Thus, a robust controlled release system remains an unmet medical need for growth-factor-based therapies. A nanoscale controlled release system (degradable protein nanocapsule) is provided via in-situ polymerization on growth factor. The release rate can be finely tuned by engineering the surface polymer composition. Improved therapeutic outcomes are achieved with the growth factor nanocapsules, as illustrated in spinal cord fusion mediated by bone morphogenetic protein-2 (BMP-2) nanocapsules.