Ankasa Regenerative Therapeutics
Chief Scientific Officer
Follow Your Bliss Farm 2005 - 2014
Owner
Stanford University 2005 - 2014
Professor
Ucsf 1996 - 2004
Associate Professor
Education:
Stanford University
University of Minnesota
Roosevelt High School
Skills:
Cell Biology Molecular Biology Teaching Cell Stem Cells Cell Culture Laboratory Research Life Sciences Science Biochemistry Medicine Genetics Clinical Research
Methods and compositions are provided for the therapeutic use of Wnt proteins, for enhancing bone growth and regeneration, including repair following injury, osseointegration of implants, and the like. In some embodiments of the invention, the compositions are administered locally, e.g. by injection at the site of an injury. For certain conditions it is desirable to provide Wnt activity for short periods of time, and an effective dose will be administered over a defined, short period of time.
Jill Helms - Stanford CA, US Roeland Nusse - Stanford CA, US Jaebeom Kim - Mountain View CA, US Philipp Leucht - Woodside CA, US
International Classification:
A61K 9/127 A61K 38/17 A61P 19/00
US Classification:
424450, 514 12
Abstract:
Methods and compositions are provided for the therapeutic use of Wnt proteins, where the Wnt protein is inserted in the non-aqueous phase of a lipid structure. In some embodiments the Wnt protein is presented in its active conformation on an outer liposome membrane or micelle. Pharmaceutical compositions of the present invention can be administered to an animal for therapeutic purposes. In some embodiments of the invention, the compositions are administered locally, e.g. by injection at the site of an injury. For certain conditions it is desirable to provide Wnt activity for short periods of time, and an effective dose will be administered over a defined, short period of time.
Use Of Liposomal Wnt Compositions To Enhance Osseointegration
Methods and compositions are provided for the therapeutic use of Wnt proteins, for enhancing bone growth and regeneration, including repair following injury, osseointegration of implants, and the like. In some embodiments of the invention, the compositions are administered locally, e.g. by injection at the site of an injury. For certain conditions it is desirable to provide Wnt activity for short periods of time, and an effective dose will be administered over a defined, short period of time.
Wnt Compositions And Methods Of Process From Serum-Free Culturing Conditions
Disclosed herein are methods and compositions for producing a Wnt polypeptide under a serum-free condition. Also disclosed herein are methods of purifying the Wnt polypeptide from a serum-free condition.
Use Of Liposomal Wnt Compositions To Enhance Osseointegration
Methods and compositions are provided for the therapeutic use of Wnt proteins, for enhancing bone growth and regeneration, including repair following injury, osseointegration of implants, and the like. In some embodiments of the invention, the compositions are administered locally, e.g. by injection at the site of an injury. For certain conditions it is desirable to provide Wnt activity for short periods of time, and an effective dose will be administered over a defined, short period of time.
Use Of Liposomal Wnt Composition To Enhance Osseointegration
Methods and compositions are provided for the therapeutic use of Wnt proteins, for enhancing bone growth and regeneration, including repair following injury, osseointegration of implants, and the like. In some embodiments of the invention, the compositions are administered locally, e.g. by injection at the site of an injury. For certain conditions it is desirable to provide Wnt activity for short periods of time, and an effective dose will be administered over a defined, short period of time.