Jianming J Tang

US Patent:

20040170996, Sep 2, 2004

Filed:

Feb 25, 2004

Appl. No.:

10/469277

Inventors:

Leland Yee - Pittsburgh PA, US
Jianming Tang - Birmingham AL, US
Richard Kaslow - Birmingham AL, US
Dirk van Leeuwen - Birmingham AL, US

International Classification:

C12Q001/70
C12Q001/68

US Classification:

435/006000, 435/005000

Abstract:

A composition and process are provided for predicting the responsiveness of an individual to therapy for a pathological condition is based on detecting nucleic acid allele sequences in an interleukin-10 regulatory region or cytotoxic t-lymphocyte antigen-4 promoter or exon region of the individual. The detected nucleic acid allele is then associated with the level of therapeutic responsiveness to a pathological condition based upon genotype. Comparison across multiple alleles and regions improves the predictive nature of the process.

US Patent:

6372435, Apr 16, 2002

Filed:

Aug 11, 2000

Appl. No.:

09/638509

Inventors:

Richard A. Kaslow - Birmingham AL
Jianming Tang - Birmingham AL

Assignee:

UAB Research Foundation - Birmingham AL

International Classification:

C12Q 168

US Classification:

435 6, 435 5, 435 911, 435 912, 514329, 544188, 544193, 544209, 544214, 544222, 544223

Abstract:

The present invention provides methods of correlating genetic variants in the beta-chemokine receptor 5 (CCR5) locus, more specifically CCR5 promoter alleles and genotypes, with HIV-1 transmission and/or disease progression in individuals and populations.