Jianhua I Huang

US Patent:

7119207, Oct 10, 2006

Filed:

Mar 16, 2001

Appl. No.:

09/811218

Inventors:

Brian Thomas O'Neill - Old Saybrook CT, US
Arthur Adam Nagel - Gales Ferry CT, US
John Michael Humphrey - Mystic CT, US
Susan Beth Sobolov-Jaynes - Ivoryton CT, US
Thomas Allen Chappie - Old Lyme CT, US
Lawrence Albert Vincent - Moosup CT, US
Eric Platt Arnold - Hebron CT, US
Jianhua Huang - Waterford CT, US

Assignee:

Pfizer INC - New York NY

International Classification:

C07D 401/06
C07D 401/08
A61K 31/4523
A61P 25/06

US Classification:

546199, 546113, 546 18, 514256, 514322, 514278, 544333

Abstract:

The present invention relates to certain benzoamide piperidine containing compounds and related compounds that exhibit activity as NK-1 receptor antagonists, (e. g. , substance P receptor antagonists), to pharmaceutical compositions containing them, and to their use in the treatment and prevention of central nervous system disorders, inflammatory disorders, cardiovascular disorders, ophthalmic disorders, gastrointestinal disorders, disorders caused by , disorders of the immune system, urinary incontinence, pain, migraine, emesis, angiogenesis and other disorders.

US Patent:

20030119844, Jun 26, 2003

Filed:

May 22, 2002

Appl. No.:

10/154482

Inventors:

Jianhua Huang - Waterford CT, US
Dario Doller - Wallingford CT, US
Ping Ge - Durham CT, US
Yasuchika Yamaguchi - Guilford CT, US

Assignee:

Neurogen Corporation - Branford CT

International Classification:

A61K031/497
A61K031/505
A61K031/506
C 07D 4 1/04
C 07D 4 3/04

US Classification:

514/252100, 514/255050, 514/256000, 544/333000, 544/405000, 546/268100, 514/336000

Abstract:

Diarylpyrazine, diarylpyridine, and diarylpyrimidine compounds that act as selective modulators of CRF 1 receptors are provided. These compounds are useful in the treatment of a number of CNS and periphereal disorders, particularly stress, anxiety, depression, cardiovascular disorders, and eating disorders. Methods of treatment of such disorders and well as packaged pharmaceutical compositions are also provided. Compounds of Formula I are also useful as probes for the localization of CRF receptors and as standards in assays for CRF receptor binding. Methods of using the compounds in receptor localization studies are given.

US Patent:

20050176721, Aug 11, 2005

Filed:

Apr 4, 2005

Appl. No.:

11/098885

Inventors:

Jianhua Huang - Waterford CT, US
Dario Doller - Wallingford CT, US
Ping Ge - Durham CT, US
Yasuchika Yamaguchi - Guilford CT, US

International Classification:

A61K031/497
A61K031/4965
A61K031/513
C07D043/02

US Classification:

514252100, 514269000, 544298000, 544408000, 514255050, 544405000

Abstract:

Diarylpyrazine, diarylpyridine, and diarylpyrimidine compounds that act as selective modulators of CRF 1 receptors are provided. These compounds are useful in the treatment of a number of CNS and periphereal disorders, particularly stress, anxiety, depression, cardiovascular disorders, and eating disorders. Methods of treatment of such disorders and well as packaged pharmaceutical compositions are also provided. Compounds of Formula I are also useful as probes for the localization of CRF receptors and as standards in assays for CRF receptor binding. Methods of using the compounds in receptor localization studies are given.