Jhobe A Steadman

US Patent:

7238521, Jul 3, 2007

Filed:

Nov 24, 2003

Appl. No.:

10/722290

Inventors:

Soonkap Hahn - San Clemente CA, US
Jhobe Steadman - San Diego CA, US
Pavel Tsinberg - San Diego CA, US
Tim Watanaskul - Oceanside CA, US
Yehudit Gerassi - San Diego CA, US

Assignee:

Biocept, Inc. - San Diego CA

International Classification:

C12M 3/00
C12M 1/00
C12Q 1/68
C01N 15/06
C01N 33/48

US Classification:

4352882, 435 6, 4352831, 4352872, 422 681

Abstract:

A novel hybridization device that improves the efficiency and consistency of microarray hybridization reactions by achieving a greater degree of internal mixing of target solution. The device provides a gasket-and-cover-type chamber wherein solution mixing is achieved by the creation of a multitude of microbubbles. One or more of the inner walls that define the chamber contain bubble-rupturing elements that extend into the chamber and terminate in sharp edges. They are typically located on opposite sides of a rectangular chamber and are pointed in a direction opposing bubble movement. Their interference with larger bubbles causes their breakup into microbubbles which travel separate and distinct paths as a result of external agitation and thereby provide improved solution mixing that results in a uniform distribution of target molecules to the probe molecules bound to the substrate. The sensitivity and consistency of the hybridization reaction is significantly increased.

US Patent:

20020009394, Jan 24, 2002

Filed:

Apr 2, 1999

Appl. No.:

09/285481

Inventors:

HUBERT KOSTER - LA JOLLA CA, US
PING YIP - SAN DIEGO CA, US
JHOBE STEADMAN - SAN DIEGO CA, US
DIRK REUTER - HAMBURG, DE
RICHARD MACDONALD - SAN DIEGO CA, US

International Classification:

G01N035/00

US Classification:

422/065000, 436/043000, 436/047000, 436/181000, 422/067000

Abstract:

A fully automated modular analytical system integrates instrumentation to permit analysis of biopolymer samples. The samples include, but are not limited to, all biopolymers, e.g., nucleic acids, proteins, peptides and carbohydrates. The system integrates analytical methods of detection and analysis, e.g., mass spectrometry, radiolabeling, mass tags, chemical tags, fluorescence chemiluminescence, and the like, with robotic technology and automated chemical reaction systems to provide a high-throughput, accurate Automated Process Line (APL).

US Patent:

20130230844, Sep 5, 2013

Filed:

Mar 1, 2013

Appl. No.:

13/783019

Inventors:

Michael Jon Hale - San Diego CA, US
Jhobe Steadman - San Diego CA, US

Assignee:

Quidel Corporation - San Diego CA

International Classification:

G01N 21/64

US Classification:

435 5, 4352872

Abstract:

A system comprised of an apparatus and a test device is described. The test device and the apparatus are designed to interact to determine the presence or absence of an analyte of interest in a sample placed on the test device.

US Patent:

6730517, May 4, 2004

Filed:

Oct 5, 2000

Appl. No.:

09/680581

Inventors:

Ping Yip - San Diego CA
Jhobe Steadman - San Diego CA
Dirk Reuter - Hamburg, DE
Richard MacDonald - San Diego CA

Assignee:

Sequenom, Inc. - San Diego CA

International Classification:

G01N 3502

US Classification:

436 47, 436 43, 436173, 436131, 422 63, 422 65, 422 67, 422102, 250251, 250282, 250287, 250288, 700266

Abstract:

Fully automated modular analytical systems with integrated instrumentation for analysis of biopolymer samples, such as nucleic acids, proteins, peptides and carbohydrates, are provided. Analytical methods of detection and analysis, such as mass spectrometry, radiolabeling, mass tags, chemical tags and fluorescence chemiluminescence, are integrated with robotic technology and automated chemical reaction systems to provide a high-throughput, accurate Automated Process Line (APL).

US Patent:

20210389316, Dec 16, 2021

Filed:

Aug 26, 2021

Appl. No.:

17/458174

Inventors:

- San Diego CA, US
Michael Jon Hale - San Diego CA, US
Jhobe Steadman - San Diego CA, US

International Classification:

G01N 33/543
G01N 21/64
G01N 33/558
G01N 33/53
B01L 9/00
G01N 21/84
G01N 33/569

Abstract:

A system comprised of an apparatus and a test device is described. The test device and the apparatus are designed to interact to determine the presence or absence of an analyte of interest in a sample placed on the test device.

US Patent:

20210041353, Feb 11, 2021

Filed:

Oct 22, 2020

Appl. No.:

17/077810

Inventors:

- San Diego CA, US
Jhobe Steadman - Poway CA, US

International Classification:

G01N 21/27
G01N 21/64

Abstract:

Disclosed herein is a method for improving the precision of a test result from an instrument with an optical system that detects a signal. The method comprises including in the instrument a normalization target disposed directly or indirectly in the optical path of the optical system. Also disclosed are instruments comprising a normalization target, and systems comprising such an instrument and a test device that receives a sample suspected of containing an analyte.

US Patent:

20200064264, Feb 27, 2020

Filed:

Oct 31, 2019

Appl. No.:

16/670228

Inventors:

- San Diego CA, US
Jhobe Steadman - Poway CA, US

International Classification:

G01N 21/64
G01N 33/543
G01N 21/27

Abstract:

Disclosed herein is a method for improving the precision of a test result from an instrument with an optical system that detects a signal. The method comprises including in the instrument a normalization target disposed directly or indirectly in the optical path of the optical system. Also disclosed are instruments comprising a normalization target, and systems comprising such an instrument and a test device that receives a sample suspected of containing an analyte.

US Patent:

20200043353, Feb 6, 2020

Filed:

Aug 1, 2018

Appl. No.:

16/051999

Inventors:

Jhobe Steadman - Poway CA, US

International Classification:

G08G 9/02

Abstract:

Disclosed are various combinations of mechanical and electronic components which comprise systems which generally serve as collision avoidance systems. The electronics subsystems are comprised of detection component(s), indicator component(s), a power source, and other necessary supporting electronics. One primary use of these systems is to alert person(s) on one side of a door that the door may open towards them. In this way, the person towards whom the door is opening is able to prevent themselves from being struck by the door. As applied to door applications, the disclosed invention encompasses systems which pass through and are rigidly mounted to the door. Other uses for these types of personal collision avoidance systems are disclosed and claimed.