Jesse B Wolinsky

US Patent:

8334324, Dec 18, 2012

Filed:

Jan 20, 2010

Appl. No.:

12/690607

Inventors:

Yolonda L. Colson - Dover MA, US
Solomon Azouz - Dallas TX, US
Mark W. Grinstaff - Brookline MA, US
Jesse Wolinsky - Brookline MA, US
Aaron Griset - Medford MA, US

Assignee:

The Trustees of the Boston University - Boston MA
The Brigham and Women's Hospital, Inc. - Boston MA

International Classification:

A61K 47/06

US Classification:

5147723

Abstract:

Described herein are compounds and processes that can be used to prepare polymer-based films, particles, gels and related compositions, and processes for delivery of agents, and other uses.

US Patent:

8338492, Dec 25, 2012

Filed:

Jun 18, 2010

Appl. No.:

12/818693

Inventors:

Yolonda L. Colson - Dover MA, US
Solomon Azouz - Dallas TX, US
Mark W. Grinstaff - Brookline MA, US
Jesse Wolinsky - Brookline MA, US
Aaron Griset - Medford MA, US

Assignee:

The Trustees of the Boston University - Boston MA
The Brigham and Women's Hospital, Inc. - Boston MA

International Classification:

A61K 47/06

US Classification:

5147723

Abstract:

Described herein are compounds and processes that can be used to prepare polymer-based films, particles, gels and related compositions, and processes for delivery of agents, and other uses.

US Patent:

20080075718, Mar 27, 2008

Filed:

May 31, 2007

Appl. No.:

11/756587

Inventors:

Yolonda Colson - Needham MA, US
Solomon Azouz - San Antonio TX, US
Mark Grinstaff - Brookline MA, US
Jesse Wolinsky - Brookline MA, US
Aaron Griset - Brookline MA, US

International Classification:

A61K 39/395
A61K 31/131
A61K 31/135
A61K 31/164
A61K 31/17
A61K 31/192
A61K 31/28
A61K 31/336
A61K 31/337
A61K 31/35
A61K 31/357
A61K 31/407
A61K 31/4164
A61K 31/445
A61K 31/496
A61K 31/4985
A61K 31/505
A61K 31/52
C08G 75/26
C08G 63/08
C07D 313/04
A61K 31/551
A61K 31/65
A61K 31/66
A61K 38/08
A61K 38/50

US Classification:

424133100, 424094600, 514110000, 514015000, 514152000, 514183000, 514215000, 514249000, 514252110, 514256000, 514263230, 514263300, 514274000, 514316000, 514398000, 514413000, 514449000, 514452000, 514459000, 514492000, 514567000, 514588000, 514589000, 514620000, 514653000, 514672000, 514748000, 528354000, 528380000, 549271000

Abstract:

Described herein are compounds and processes that can be used to prepare polymer-based films, particles, gels and related compositions, and processes for delivery of agents, and other uses.

US Patent:

20110172785, Jul 14, 2011

Filed:

May 7, 2009

Appl. No.:

12/991944

Inventors:

Jesse Wolinsky - Brookline MA, US
Mark W. Grinstaff - Brookline MA, US
Yolonda L. Colson - Dover MA, US

Assignee:

THE TRUSTEES OF BOSTON UNIVERSITY - Boston MA
THE BRIGHAM AND WOMEN'S HOSPITAL, INC. - Boston MA

International Classification:

A61F 2/02
B05D 7/00

US Classification:

623 2372, 427 224

Abstract:

A compliant composite for delivering a bioactive agent including a scaffolding material and a polymer coating that together can be attached to compliant tissue surfaces is disclosed, along with methods for constructing and applying these composites. In some embodiments, the composite further comprises a barrier layer for localized delivery of the bioactive agent.

US Patent:

20130195954, Aug 1, 2013

Filed:

Nov 8, 2012

Appl. No.:

13/672628

Inventors:

The Brigham and Women's Hospital - Boston MA, US
The Trustees of the Boston University - Boston MA, US
Mark W. Grinstaff - Brookline MA, US
Jesse Wolinsky - Brookline MA, US
Aaron Griset - Medford MA, US

Assignee:

THE TRUSTEES OF THE BOSTON UNIVERSITY - Boston MA
THE BRIGHAM AND WOMEN'S HOSPITAL - Boston MA

International Classification:

A61K 47/32
C08F 124/00
A61K 31/519
C07D 319/06
A61K 31/337

US Classification:

424443, 549370, 5147724, 514449, 5142651, 526266, 526268, 428402

Abstract:

Described herein are compounds and processes that can be used to prepare polymer-based films, particles, gels and related compositions, and processes for delivery of agents, and other uses.

US Patent:

20150037375, Feb 5, 2015

Filed:

Jul 19, 2012

Appl. No.:

14/233570

Inventors:

Mark W. Grinstaff - Brookline MA, US
Jesse Wolinsky - Brookline MA, US
Stefan Yohe - Cambridge MA, US
Jonah Andrew Kaplan - Newton MA, US
Eric John Falde - Maplewood MN, US
Joseph Steven Hersey - Boston MA, US

Assignee:

TRUSTEES OF BOSTON UNIVERSITY ET AL - Boston MA

International Classification:

A61L 31/14
A61L 31/16
A61L 31/06

US Classification:

424400, 514283

Abstract:

Provided herein are 3-dimensional drug-eluting materials comprising biodegradable polymer(s), one or more bioactive agents and entrapped air. Various embodiments of the methods and compositions described herein are based, in part, on the discovery of hydrophobic doping agents that can be used in the manufacture of polymeric drug delivery compositions that permit the encapsulation of air, thereby permitting tunable drug release via controlled air removal. Such compositions are particularly useful for delivering therapeutically effective doses of one or more bioactive agents to a subject over an extended period of time (e.g., days, weeks, or months).