Jesper M Haaning

US Patent:

20100260741, Oct 14, 2010

Filed:

Feb 17, 2010

Appl. No.:

12/707453

Inventors:

Jesper Mortensen Haaning - Redwood City CA, US
Kim Vilbour Andersen - Broenshoej, DK

International Classification:

A61K 38/48
C12N 9/96
A61P 7/04

US Classification:

424 9464, 435188

Abstract:

The present invention relates to novel polypeptide variants of factor VII (FVII) or factor VIIa (FVIIa) polypeptides, where said variants comprise an amino acid substitution in position 10 and 32 and where said variants further comprise a sugar moiety covalently attached to an introduced in vivo N-glycosylation site located outside of the Gla domain. Such polypeptide variants are useful in therapy, in particular for the treatment of a variety of coagulation-related disorders, such as trauma.