Gary D. Lair - San Diego CA, US Thanh N. Nguyen - San Diego CA, US Haitao Li - San Diego CA, US Florence F. Li - San Diego CA, US Byron J. Knight - San Diego CA, US Robert E. Heinz - San Diego CA, US Jerzy A. Macioszek - San Diego CA, US Christopher B. Davis - San Diego CA, US Robert F. Scalese - Escondido CA, US
An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a sample, incubating the sample, preforming an analyte isolation procedure, ascertaining the presence of a target analyte, and analyzing the amount of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte, and, in one embodiment, a method for real-time monitoring of the amplification process.
Jerzy A. Macioszek - San Diego CA, US Christopher B. Davis - San Diego CA, US Gary D. Lair - San Diego CA, US Thanh N. Nguyen - San Diego CA, US Haitao Li - San Diego CA, US Florence F. Li - San Diego CA, US Byron J. Knight - San Diego CA, US Robert F. Scalese - Escondido CA, US Robert E. Heinz - San Diego CA, US
Assignee:
Gen-Probe Incorporated - San Diego CA
International Classification:
C12Q 1/68
US Classification:
435 6
Abstract:
An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations in which discrete aspects of the assay are performed on fluid samples contained in sample vessels. The analyzer includes stations for automatically preparing a sample, incubating the sample, preforming an analyte isolation procedure, ascertaining the presence of a target analyte, and analyzing the amount of a target analyte. An automated receptacle transporting system moves the sample vessels from one station to the next. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte, and, in one embodiment, a method for real-time monitoring of the amplification process.
Signal Measuring System For Conducting Real-Time Amplification Assays
Gary D. Lair - San Diego CA, US Thanh N. Nguyen - San Diego CA, US Haitao Li - San Diego CA, US Florence F. Li - San Diego CA, US Byron J. Knight - San Diego CA, US Robert E. Heinz - San Diego CA, US Jerzy A. Macioszek - San Diego CA, US Christopher B. Davis - San Diego CA, US Robert F. Scalese - Escondido CA, US
An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations in which discrete aspects of the assay are performed on fluid samples contained in sample vessels. The analyzer includes stations for automatically preparing a sample, incubating the sample, preforming an analyte isolation procedure, ascertaining the presence of a target analyte, and analyzing the amount of a target analyte. An automated receptacle transporting system moves the sample vessels from one station to the next. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte, and, in one embodiment, a method for real-time monitoring of the amplification process.
Method For Continuous Mode Processing Of Multiple Reaction Receptacles In A Real-Time Amplification Assay
Jerzy A. Macioszek - San Diego CA, US Christopher B. Davis - San Diego CA, US Gary D. Lair - San Diego CA, US Thanh N. Nguyen - San Diego CA, US Haitao Li - San Diego CA, US Florence F. Li - San Diego CA, US Byron J. Knight - San Diego CA, US Robert F. Scalese - Escondido CA, US Robert E. Heinz - San Diego CA, US
An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations in which discrete aspects of the assay are performed on fluid samples contained in sample vessels. The analyzer includes stations for automatically preparing a sample, incubating the sample, preforming an analyte isolation procedure, ascertaining the presence of a target analyte, and analyzing the amount of a target analyte. An automated receptacle transporting system moves the sample vessels from one station to the next. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte, and, in one embodiment, a method for real-time monitoring of the amplification process.
Gary D. Lair - San Diego CA, US Thanh N. Nguyen - San Diego CA, US Haitao Li - San Diego CA, US Florence F. Li - San Diego CA, US Byron J. Knight - San Diego CA, US Robert E. Heinz - San Diego CA, US Jerzy A. Macioszek - San Diego CA, US Christopher B. Davis - San Diego CA, US Robert F. Scalese - Escondido CA, US
An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations in which discrete aspects of the assay are performed on fluid samples contained in sample vessels. The analyzer includes stations for automatically preparing a sample, incubating the sample, preforming an analyte isolation procedure, ascertaining the presence of a target analyte, and analyzing the amount of a target analyte. An automated receptacle transporting system moves the sample vessels from one station to the next. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte, and, in one embodiment, a method for real-time monitoring of the amplification process.
Method For Continuous Mode Processing Of The Contents Of Multiple Reaction Receptacles In A Real-Time Amplification Assay
Jerzy A. Macioszek - San Diego CA, US Christopher B. Davis - San Diego CA, US Gary D. Lair - San Diego CA, US Thanh N. Nguyen - Liguna Niguel CA, US Haitao Li - San Diego CA, US Florence F. Li - San Diego CA, US Byron J. Knight - San Diego CA, US Robert F. Scalese - Escondido CA, US Robert E. Heinz - San Diego CA, US
An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations in which discrete aspects of the assay are performed on fluid samples contained in sample vessels. The analyzer includes stations for automatically preparing a sample, incubating the sample, preforming an analyte isolation procedure, ascertaining the presence of a target analyte, and analyzing the amount of a target analyte. An automated receptacle transporting system moves the sample vessels from one station to the next. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte, and, in one embodiment, a method for real-time monitoring of the amplification process.
System For Continuous Mode Processing Of The Contents Of Multiple Reaction Receptacles In A Real-Time Amplification Assay
Jerzy A. MACIOSZEK - San Diego CA, US Christopher B. DAVIS - San Diego CA, US Gary D. LAIR - San Diego CA, US Thanh N. NGUYEN - Liguna Niguel CA, US Haitao LI - San Diego CA, US Florence F. LI - San Diego CA, US Byron J. KNIGHT - San Diego CA, US Robert F. SCALESE - Escondido CA, US Robert E. HEINZ - San Diego CA, US
Assignee:
GEN-PROBE INCORPORATED - San Diego CA
International Classification:
G01N 21/01 G01N 23/10
US Classification:
250429
Abstract:
An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations in which discrete aspects of the assay are performed on fluid samples contained in sample vessels. The analyzer includes stations for automatically preparing a sample, incubating the sample, preforming an analyte isolation procedure, ascertaining the presence of a target analyte, and analyzing the amount of a target analyte. An automated receptacle transporting system moves the sample vessels from one station to the next. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte, and, in one embodiment, a method for real-time monitoring of the amplification process.
Continuous Process For Performing Multiple Nucleic Acid Amplification Assays
- San Diego CA, US Thanh N. NGUYEN - Laguna Niguel CA, US Haitao LI - San Diego CA, US Florence LI - San Diego CA, US Byron J. KNIGHT - San Diego CA, US Robert E. HEINZ - San Diego CA, US Jerzy A. MACIOSZEK - Chevy Chase MD, US Christopher B. DAVIS - San Diego CA, US Robert F. SCALESE - Carlsbad CA, US
A method of determining the presence or amount of a target nucleic acid in each of a plurality of reaction mixtures. In the method, a first plurality of reaction mixtures are provided to a heater and subjected to conditions for performing a first amplification reaction. The presence or amount of a first target nucleic acid in each of the first plurality of reaction mixtures is determined during the first amplification reaction. During the first amplification reaction, a second plurality of reaction mixtures are provided to the heater and subjected to conditions for performing a second amplification reaction. The presence or amount of a second target nucleic acid in each of the second plurality of reaction mixtures is determined during the second amplification reaction. At least a portion of the second plurality of reaction mixtures are removed from the heater during the second amplification reaction.
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