Jerome Linder

US Patent:

40027511, Jan 11, 1977

Filed:

May 2, 1975

Appl. No.:

5/574049

Inventors:

Jerome Linder - Westfield NJ

Assignee:

Sandoz, Inc. - E. Hanover NJ

International Classification:

C07D23714
A61K 3150

US Classification:

424250

Abstract:

Substituted 5-hydrazinopyridazin-3(2H)-ones, e. g. , 4-chloro-2-(3-trifluoromethylphenyl)-5-(1-methylhydrazino)-pyridazin-3(2H) -one or 4-chloro-2-(2-fluoro-5-trifluoromethylphenyl)-5-(1-methylhydrazino)-pyrida zin-3(2H)-one, are prepared by treating halogenated pyridazin-3-(2H)-ones with hydrazine and substituted hydrazines and are useful as central nervous system depressants and sleep inducers.

US Patent:

40214923, May 3, 1977

Filed:

Nov 12, 1975

Appl. No.:

5/630971

Inventors:

Jerome Linder - Westfield NJ
William J. Houlihan - Mountain Lakes NJ

Assignee:

Sandoz, Inc. - E. Hanover NJ

International Classification:

C07C 4980

US Classification:

260592

Abstract:

The. alpha. ,. alpha. -dibromo-substituted or unsubstituted-4-pivaloyl toluenes, e. g. ,. alpha. ,. alpha. -dibromo-4-pivaloyl toluene, are prepared by bromination of a corresponding p-pivaloyl toluene with liquid bromine at a temperature of at least 125. degree. C.

US Patent:

39623424, Jun 8, 1976

Filed:

Mar 24, 1975

Appl. No.:

5/561485

Inventors:

Jerome Linder - Westfield NJ
William J. Houlihan - Mountain Lakes NJ

Assignee:

Sandoz, Inc. - E. Hanover NJ

International Classification:

C07C 4980

US Classification:

260592

Abstract:

The. alpha. -bromo-substituted or unsubstituted-4-pivaloyl toluenes, e. g. ,. alpha. -bromo-4-pivaloyl toluene, are prepared by bromination of a corresponding p-pivaloyl toluene with liquid bromine at a temperature of at least 100. degree. C.

US Patent:

49887890, Jan 29, 1991

Filed:

Jan 5, 1990

Appl. No.:

7/461157

Inventors:

Jerome Linder - Westfield NJ

Assignee:

Sandoz Ltd. - Basel

International Classification:

C07C22700

US Classification:

562575

Abstract:

An improved process for preparing glycine hydrochloride in a high purity and high yield employing water as the solvent.