Jennipher L Grudzien

US Patent:

7063979, Jun 20, 2006

Filed:

Jun 13, 2002

Appl. No.:

10/171128

Inventors:

Gavin MacBeath - Arlington MA, US
Jennipher Grudzien - Metamora MI, US

Assignee:

Grace Bio Labs., Inc. - Bend OR
President and Fellows of Harvard College - Cambridge MA

International Classification:

C12M 1/18
B01L 3/00

US Classification:

4353052, 4352884, 422102

Abstract:

The invention describes a process for preparing a microtiter-microarray device that includes a bottomless microtiter plate attached to the first side of one or more substrates with microarrays of materials attached thereto. The microtiter plate and the one or more substrates are attached through one or more gaskets. Preferably, the microtiter plate is attached to one face of the one or more gaskets by an irreversible water-tight seal, and the first side of the one or more substrates is attached to the opposite face of the one or more gaskets by a reversible, water-tight seal.

US Patent:

7731909, Jun 8, 2010

Filed:

Feb 20, 2004

Appl. No.:

10/784092

Inventors:

Jennipher Grudzien - Metamora MI, US
Charles M. McGrath - Bend OR, US

Assignee:

Grace Bio-Labs, Inc. - Bend OR

International Classification:

B01L 3/00

US Classification:

422102, 422104

Abstract:

A reaction surface array diagnostic apparatus and method of making the same includes a substrate carrying a plurality of reaction surfaces, a plate and a gasket, each having a plurality of through bores, alignable with one of the reaction surfaces and forming a fluid tight well about each reaction surface when the gasket and the plate are sealingly affixed to the substrate to form a stack. Clamp members engage opposite side edges of a stack to compress the gasket. A plurality of side-by-side disposed clamped stacks of plates, gaskets and substrates are mounted in a tray in the standard footprint of a microtiter plate. Alternately, the plate and the gasket are combined into a single plate formed of a flexible material having an adhesive on one surface.

US Patent:

8034306, Oct 11, 2011

Filed:

Sep 28, 2005

Appl. No.:

11/236979

Inventors:

Jennipher Grudzien - Metamora MI, US
Charles McGrath - Bend OR, US

Assignee:

Grace Bio-Labs, Inc. - Bend OR

International Classification:

B01L 3/00

US Classification:

422553, 422552, 422560, 422561, 422562, 422563

Abstract:

A reaction surface array diagnostic apparatus includes a substrate carrying a plurality of reaction surfaces and, a plate having a plurality of wells, alignable with one of the reaction surfaces and forming a fluid tight well about each reaction surface when the plate and the substrate are sealingly affixed to each other in a frame. The plate is formed of a flexible material which may have an adhesive on one surface. Interlocking latch members are formed on the plate and the frame for releasably latching the plate and the frame in a position for sealing attachment to the substrate.

US Patent:

8287822, Oct 16, 2012

Filed:

May 14, 2010

Appl. No.:

12/780639

Inventors:

Jennipher Grudzien - Bend OR, US
Charles M. McGrath - Bend OR, US

Assignee:

Grace Bio-Labs, Inc. - Bend OR

International Classification:

B01L 3/00

US Classification:

422552, 422547, 422551, 422553

Abstract:

A reaction surface array diagnostic apparatus and method of making the same includes a substrate carrying a plurality of reaction surfaces, a plate and a gasket, each having a plurality of through bores, alignable with one of the reaction surfaces and forming a fluid tight well about each reaction surface when the gasket and the plate are sealingly affixed to the substrate to form a stack. Clamp members engage opposite side edges of a stack to compress the gasket. A plurality of side-by-side disposed clamped stacks of plates, gaskets and substrates are mounted in a tray in the standard footprint of a microtitre plate. Alternately, the plate and the gasket are combined into a single plate formed of a flexible material having an adhesive on one surface.

US Patent:

51925036, Mar 9, 1993

Filed:

May 23, 1990

Appl. No.:

7/528067

Inventors:

Charles M. McGrath - Troy MI
Jennipher Grudzien - Metamora MI

International Classification:

G01N 2101
G01N 2178
B65D 4902
B65D 4908

US Classification:

422 57

Abstract:

A probe clip for in situ assay of tissue sections in the form of a plate having a first seal member mounted thereon and forming an interior cavity on the plate. In one embodiment, a second seal member is mounted interiorly of the first seal member and divides the interior cavity into first and second fluid communicatable surfaces, with a probe dryingly attached to the plate and disposed on the second mixing surface. The plate is joined to a slide carrying a tissue section and a reactant fluid such to form fluid communicatable reaction and mixing chambers. Successive rotations of the joined plate and slide causes the reactant fluid to initially flow to the mixing chamber and release the probe, before the probe flows to the reaction chamber for reaction with the tissue section. In another embodiment, a time-release material covers the probe mounted on a plate having a single chamber. The reactant fluid hydrolyzes the time-release material to release the probe for reaction with the tissue.

US Patent:

20180264464, Sep 20, 2018

Filed:

May 24, 2018

Appl. No.:

15/989045

Inventors:

- Bend OR, US
Joshua Snider - Aloha OR, US
Steven Weaver - Bend OR, US
Jennipher Lyn Grudzien - Bend OR, US
Kelsey Anne Muller - Bend OR, US
Stephen E. Moody - Woodinville WA, US

International Classification:

B01L 3/00
G01N 33/487
G01N 21/64

Abstract:

Methods and systems are provided making a porous nitrocellulose strip for use in a lateral flow test. The strip may be formed from a liquid polymer mixture dispensed onto the planar surface via a dispensing device positioned vertically above the planar surface. The strip may be printed with a microarray of binding ligands for use in the lateral flow test. Methods and systems are further provided for developing and viewing the results of the assay.

US Patent:

20170099415, Apr 6, 2017

Filed:

Sep 27, 2016

Appl. No.:

15/277746

Inventors:

- Bend OR, US
Jacob Burrel Wells - Bend OR, US
Donna Kay Barton - Bend OR, US
Jennipher Lyn Grudzien - Bend OR, US

International Classification:

H04N 5/225
H04N 5/232
G01N 33/543
G02B 27/14

Abstract:

Methods and systems are provided for imaging a microarray of a microarray assembly. The microarray assembly may be configured as a protein microarray and may be used to visualize protein expression levels in sample for disease detection and/or diagnosis. In one example, the microarray assembly may comprise a laser pointed in a first direction, a camera positioned parallel to and vertically below the laser, a first dichroic mirror vertically aligned with the laser for reflecting light emitted from the laser, a second mirror vertically aligned with the camera and horizontally aligned with the first dichroic mirror, and a chip coated in a nitrocellulose film and including an array of wells containing one or more biomolecules.

US Patent:

20160121323, May 5, 2016

Filed:

Nov 3, 2015

Appl. No.:

14/931512

Inventors:

- Bend OR, US
Joshua Snider - Bend OR, US
Steven Weaver - Bend OR, US
Jennipher Grudzien - Bend OR, US

International Classification:

B01L 3/00
G01N 33/558
B05D 3/00
B05B 3/18
B05D 1/02

Abstract:

Methods and systems are provided for a lateral flow test device. In one example a lateral flow test device may include a housing comprising an upper first portion and a lower second portion, the lower second portion further including a planar surface, a nitrocellulose matrix strip, the strip disposed on the planar surface, and one or more ligand regions included in the strip, the ligand regions comprising one or more ligands. The strip may be formed from a liquid polymer mixture dispensed onto the planar surface via a dispensing device positioned vertically above the planar surface.