Jeffrey T Vicenzi

US Patent:

6506726, Jan 14, 2003

Filed:

Dec 10, 2001

Appl. No.:

09/857924

Inventors:

John Robert Dobbins - Indianapolis IN
Eugene Paul Kroeff - Carmel IN
Jeffrey Thomas Vicenzi - Brownsburg IN

Assignee:

Eli Lilly and Company - Indianapolis IN

International Classification:

A61K 3800

US Classification:

514 11, 514 9, 514 2, 530317, 530344, 530345

Abstract:

A method is described for separating and purifying a wide variety of fermentation cyclopeptide products containing at least one protonatable amino group (including the deacylated Echinocandin-type compounds) from their fermentation or mixed broths and partially purified process streams by adsorbing the mixture onto a hydrophobic, reversed phase chromatographic media and eluting with a continuous linear acetic acid gradient ranging from 0. 1% acetic acid to 10. 0% acetic acid by volume in water. A process for removing tripeptide-aldehyde by-products from the fermentation products by means of a derivatizing agent is also described.

US Patent:

6590073, Jul 8, 2003

Filed:

Aug 30, 2001

Appl. No.:

09/944309

Inventors:

Brian Weston Dalder - West Lafayette IN
Michael Anthony Dotlich - Lafayette IN
Neil John Kallman - Lafayette IN
Samuel Dean Larsen - West Lafayette IN
Sharon Van Den Berghe Snorek - Lafayette IN
Jeffrey Thomas Vicenzi - Brownsburg IN

Assignee:

Eli Lilly and Company - Indianapolis IN

International Classification:

A61K 3812

US Classification:

530317, 530344, 530345, 530300, 514 11, 514 9, 514 2, 435 711

Abstract:

A method is described for forming a crystalline Echinocandin nucleus salt from its mixed broth and/or partially purified process streams by the steps of nanofiltration to form a concentrate, addition of an aldehyde derivatizing agent which interacts with an aldehyde impurity, addition of an acid/metal salt to form a solubilized echinocandin nucleus salt having the desired anion, and subsequent cooling of the mixture to crystallize the salt.

US Patent:

20040102500, May 27, 2004

Filed:

Sep 11, 2003

Appl. No.:

10/415673

Inventors:

Ivan Cano - Alcobendas, ES
Samuel Dominianni - Indianapolis IN, US
Garret Etgen - Carmel IN, US
Cristina Garcia-Paredes - Alcobendas Madrid, ES
Richard Johnston - Greenfield IN, US
Michael Letourneau - Indianapolis IN, US
Nathan Mantlo - Brownsburg IN, US
Michael Martinelli - Zionsville IN, US
Daniel Mayhugh - Carmel IN, US
Ashraf Saeed - Carmel IN, US
Richard Thompson - Frankfort IN, US
Xiaodong Wang - Carmel IN, US
David Coffey - Indianapolis IN, US
Christopher Schmid - Indianapolis IN, US
Jeffrey Vicenzi - Brownsburg IN, US
Yanping Xu - Fishers IN, US

International Classification:

A61K031/4196
C07D249/12
C 07D 4 3/02

US Classification:

514/384000, 548/263400, 548/263200

Abstract:

The present invention is directed to compounds represented by the following structural formula, and pharmaceutically acceptable salts, solvates and hydrates thereof, R1 is a substituted or unsubstituted group selected from C-Calkyl, aryl-C-alkyl, heteroaryl-C-alkyl, C-Ccycloalkylaryl-C-alkyl or phenyl. W is O or S. R2 is H or a substituted or unsubstituted group selected from C-Calkyl, C-Ccycloalkyl and heteroaryl. X is a C-Calkylene linker wherein one carbon atom of the linker may be replaced with O, NH or S. Y is C, O, S, NH or a single bond. Furthermore, E is (CH)COOH, wherein n is 0, 1, 2 or 3, or C(R3)(R4)A, wherein A is an acidic functional group such as carboxyl, carboxamide substituted or unsubstituted sulfonamide, or substituted or unsubstituted tetrazole. R3 is H, saturated or unsaturated C-Calkyl, C-Calkoxy. Additionally, R4 is H, halo, a substituted or unsubstituted group selected from C-Calkyl, C-Calkoxy, C-Ccycloalkyl, arylC-Calkyl and phenyl, or R3 and R4 are combined to form a C-Ccycloalkyl.

US Patent:

20090062358, Mar 5, 2009

Filed:

Jul 26, 2007

Appl. No.:

11/828446

Inventors:

Ivan Collado Cano - Alcobendas, ES
Samuel James Dominianni - Indianapolis IN, US
Cristina Garcia-Paredes - Alcobendas, ES
Richard Duane Johnston - Greenfield IN, US
Michael Edward Letourneau - Indianapolis IN, US
Nathan Bryan Mantlo - Brownsburg IN, US
Michael John Martinelli - Zionsville IN, US
Daniel Ray Mayhugh - Carmel IN, US
Ashraf Saeed - Framingham MA, US
Richard Craig Thompson - Frankfort IN, US
Xiaodong Wang - Carmel IN, US
David Scott Coffey - Indianapolis IN, US
Christopher Randall Schmid - Indianapolis IN, US
Jeffrey Thomas Vicenzi - Brownsburg IN, US
Yanping Xu - Fishers IN, US

International Classification:

A61K 31/4196
C07D 249/12
C07D 405/02

US Classification:

514384, 5482632

Abstract:

The present invention is directed to compounds represented by the following structural formula, and pharmaceutically acceptable salts, solvates and hydrates thereof,R1 is a substituted or unsubstituted group selected from C-Calkyl, aryl-C-alkyl, heteroaryl-C-alkyl, C3-C6 cycloalkylaryl-C-alkyl or phenyl. W is O or S. R2 is H or a substituted or unsubstituted group selected from C-Calkyl, C-Ccycloalkyl and heteroaryl. X is a C-Calkylene linker wherein one carbon atom of the linker may be replaced with O, NH or S. Y is C, O, S, NH or a single bond. Furthermore, E is (CH)COOH, wherein n is 0, 1, 2 or 3, or C(R3)(R4)A, wherein A is an acidic functional group such as carboxyl, carboxamide substituted or unsubstituted sulfonamide, or substituted or unsubstituted tetrazole. R3 is H, saturated or unsaturated C-Calkyl, C-Calkoxy. Additionally, R4 is H, halo, a substituted or unsubstituted group selected from C-Calkyl, C-Calkoxy, C-Ccycloalkyl, arylC-Calkyl and phenyl, or R3 and R4 are combined to form a C-Ccycloalkyl.

US Patent:

59691573, Oct 19, 1999

Filed:

Nov 18, 1997

Appl. No.:

8/972783

Inventors:

Jeffrey Thomas Vicenzi - Brownsburg IN

Assignee:

Eli Lilly and Company - Indianapolis IN

International Classification:

C07D33352
C07D40900
C07D40500

US Classification:

549 51

Abstract:

The instant invention provides improved processes for preparing benzothiophenes utilizing methanesulfonic acid.

US Patent:

59199547, Jul 6, 1999

Filed:

Apr 14, 1997

Appl. No.:

8/843307

Inventors:

Benjamin A. Anderson - Zionsville IN
Marvin M. Hansen - Indianapolis IN
David L. Varie - Indianapolis IN
Jeffrey T. Vicenzi - Brownsburg IN
Milton J. Zmijewski - Carmel IN

Assignee:

Eli Lilly and Company - Indianapolis IN

International Classification:

C07D31758

US Classification:

549442

Abstract:

A process for stereoselectively forming N-substituted dihydro-2,3 benzodiazepines which are useful as AMPA receptor antagonists. The process includes an opening reduction step which sets the stereochemistry of the intermediates and the final compounds to the desired enantiomer. The reduction step may be carried out by an enzymatic reduction.

US Patent:

55590063, Sep 24, 1996

Filed:

Feb 22, 1995

Appl. No.:

8/392438

Inventors:

Jeffrey T. Vicenzi - Indianapolis IN

Assignee:

Eli Lilly and Company - Indianapolis IN

International Classification:

C12N 902
C12N 908
C12N 999
C12P 3500

US Classification:

435 47

Abstract:

"A method for selectively deactivating catalase while retaining D-amino acid oxidase activity is disclosed. The catalase and oxidase are both present in whole cells or a cell-free extract. The method comprises combining the whole cells or the cell-free extract with a basic solution at a pH between about 11 and about 12. The catalase activity is eliminated and the oxidase activity is unaffected. This results in the production of a solution which contains oxidase activity but no catalase activity. The whole cells and cell-free extract are preferably from Triginopsis variabilis. ".

US Patent:

59773839, Nov 2, 1999

Filed:

Sep 22, 1997

Appl. No.:

8/934999

Inventors:

Jeffrey Thomas Vicenzi - Brownsburg IN
Tony Yantao Zhang - Indianapolis IN

Assignee:

Eli Lilly and Company - Indianapolis IN

International Classification:

C07D33356

US Classification:

549 58

Abstract:

The instant invention provides improved processes for preparing benzothiophenes utilizing cation exchange resins.