Jeffrey K Teumer

US Patent:

20030161815, Aug 28, 2003

Filed:

Feb 12, 2002

Appl. No.:

10/074221

Inventors:

Richard Wolowacz - Glossop, GB
Michael Leek - Rixton, GB
Paul Kemp - Stockport, GB
Jeffrey Teumer - Brookline MA, US

Assignee:

Intercytex Limited

International Classification:

A61K007/06

US Classification:

424/093700, 435/373000, 424/070100

Abstract:

The present invention provides a method for inducing organ or tissue formation by delivering inductive cells into an organ or tissue regenerative cellular environment using a controlled delivery device. For the regeneration of hair, the method includes inducing hair follicle formation by delivering inductive cells into a dermal layer using a controlled delivery device. The present invention further provides a method for using a controlled delivery device for the delivery of inductive cells into an organ or tissue regenerative cellular environment to induce organ or tissue formation. The method for using the controlled delivery device includes delivering inductive cells into a dermal layer to induce hair follicle formation.

US Patent:

20050147652, Jul 7, 2005

Filed:

Feb 10, 2003

Appl. No.:

10/504789

Inventors:

Jane Atkins - Woburn MA, US
Michael Leek - Rixton, GB
Paul Kemp - Cheshire, GB
Richard Wolowacz - Derbyshire, GB
Jeffrey Teumer - Brookline MA, US

International Classification:

A61K007/06
A61K009/70

US Classification:

424443000, 424070100

Abstract:

Baldness or hair loss has been treated using pharmaceutical drugs and/or hair transplant surgery. The present invention relates to an improved method for treating baldness. In one aspect, there is provided a method for inducing hair follicle formation in a dermal layer lying beneath an outer skin surface, comprising delivering inductive dermal sheath cells and/or inductive dermal papilla cells directly into the dermal layer using a controlled delivery device. Delivery of the inductive cells need not be into pre-existing pores. Use of a controlled delivery device for the treatment of baldness is a further aspect of the invention.

US Patent:

20050272150, Dec 8, 2005

Filed:

Nov 14, 2003

Appl. No.:

10/534428

Inventors:

Jeffrey Teumer - Brookline MA, US
Erica Philips - Lowell MA, US
Richard Wolowacz - Derbyshire, GB

International Classification:

C12N005/08

US Classification:

435371000

Abstract:

The present invention relates to culturing cells which may be used in hair induction. In one aspect of the invention there is provided a method for cultivation of hair inductive cells, comprising the step of culturing the hair inductive cells in a culture medium comprising a medium conditioned by conditioning cells, in which the conditioning cells are derived from non-epidermal tissue.

US Patent:

20070253939, Nov 1, 2007

Filed:

Apr 16, 2007

Appl. No.:

11/787273

Inventors:

Jane Atkins - Woburn MA, US
Michael Leek - Rixton, GB
Paul Kemp - Romiley, GB
Richard Wolowacz - Glossop, GB
Jeffrey Teumer - Brookline MA, US

Assignee:

Intercytex Limited - Manchester

International Classification:

A61K 35/36
A61Q 7/00

US Classification:

424093700

Abstract:

Baldness or hair loss has been treated using pharmaceutical drugs and/or hair transplant surgery. The present invention relates to an improved method for treating baldness. In one aspect, there is provided a method for inducing hair follicle formation in a dermal layer lying beneath an outer skin surface, comprising delivering inductive dermal sheath cells and/or inductive dermal papilla cells directly into the dermal layer using a controlled delivery device. Delivery of the inductive cells need not be into pre-existing pores. Use of a controlled delivery device for the treatment of baldness is a further aspect of the invention.

US Patent:

20070255254, Nov 1, 2007

Filed:

Apr 16, 2007

Appl. No.:

11/787340

Inventors:

Jane Atkins - Woburn MA, US
Michael Leek - Rixton, GB
Paul Kemp - Romiley, GB
Richard Wolowacz - Glossop, GB
Jeffrey Teumer - Brookline MA, US

Assignee:

Intercytex Limited - Manchester

International Classification:

A61K 35/36

US Classification:

604522000

Abstract:

Baldness or hair loss has been treated using pharmaceutical drugs and/or hair transplant surgery. The present invention relates to an improved method for treating baldness. In one aspect, there is provided a method for inducing hair follicle formation in a dermal layer lying beneath an outer skin surface, comprising delivering inductive dermal sheath cells and/or inductive dermal papilla cells directly into the dermal layer using a controlled delivery device. Delivery of the inductive cells need not be into pre-existing pores. Use of a controlled delivery device for the treatment of baldness is a further aspect of the invention.

US Patent:

20090198336, Aug 6, 2009

Filed:

Mar 15, 2007

Appl. No.:

12/293402

Inventors:

Jizeng Qiao - Lexington MA, US
Jeffrey Keeler Teumer - Brookline MA, US
Erica Jean Philips - Lowell MA, US

International Classification:

A61F 2/10
C12N 5/08
C12Q 1/02

US Classification:

623 1511, 435373, 435 29

Abstract:

This invention relates to methods of producing hair folliclesin vitro, compositions for producing hair follicles in vitro, in vitro produced hair follicles, methods of providing an in vitro produced hair shaft at an interfollicular or intrafollicular site, methods of treating hair loss by providing an in vitro produced hair shaft at an interfollicular or intrafollicular site and assays for studying the effect of test agents on hair biology. The invention also provides the similar methods and products which are, or use, immature follicles (“defined herein as proto-hairs”). The invention provides a method for in vitro production of a hair follicle or a proto-hair comprising co-culturing dermal papilla cells with keratinocytes, and optionally with melanocytes.

US Patent:

20110086007, Apr 14, 2011

Filed:

Sep 18, 2008

Appl. No.:

12/678957

Inventors:

Paul Kemp - Manchester, GB
Jeffrey Teumer - Woburn MA, US
Jerry Cooley - Charlotte NC, US

International Classification:

A61K 35/12
A61P 17/14

US Classification:

424 937

Abstract:

The present invention features a method for improving the efficiency of hair formation by follicular cell implantation. The method includes the use of epidermal stimulation (ES) to stimulate keratinocytes in a subject's skin in order to make them more receptive to hair inductive signals originating from implanted follicular cells (e.g. dermal papilla cells, dermal sheath cells, and/or outer root sheath cells).

US Patent:

20120128632, May 24, 2012

Filed:

Jul 22, 2010

Appl. No.:

13/386456

Inventors:

Jeffrey Keeler Teumer - Brookline MA, US
Vladimir Mastyugin - Lexington MA, US
Jizeng Qiao - Lexington MA, US
Agatha Zawadzka - Essex MA, US

International Classification:

A61K 35/36
A61M 5/00
A61P 17/14
G01N 33/567
C12N 5/02

US Classification:

424 933, 435 721, 435347, 435383, 604 9301

Abstract:

Methods for identifying trichogenic dermal cells, including dermal papilla cells and dermal sheath cells, capable of inducing hair follicle formation when injected into skin are provided. It has been discovered that EGF latrophilin and seven transmembrane domain-containing protein 1 (ELTD1). Transmembrane Protein 108 (TMEM1 08), Hyaluronan and proteoglycan link protein 1 (HAPLN1) are biomarkers that can be used to detect, identify, and distinguish trichogenic dermal cells, i.e., that are able to induce hair follicle formation, from other skin cells. Populations of skin cells enriched with trichogenic dermal cells can be produced by selecting for and enriching for dermal cells that express ELTD1, TMEM1 08, HAPLN1, or a combination thereof.