Jeffrey William Ruberti from Lincoln, MA, age 62

Us Patents

Layered Aligned Polymer Structures And Methods Of Making Same
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US Patent:

7048963, May 23, 2006
Filed:

Nov 27, 2002
Appl. No.:

10/306825
Inventors:

Gavin J. C. Braithwaite - Cambridge MA, US
Jeffrey W. Ruberti - Lexington MA, US
Assignee:

Cambridge Polymers Group, Inc. - Boston MA
International Classification:

B05D 3/12
US Classification:

427 224, 427240, 427425
Abstract:

This invention includes a method of producing a thin, oriented layer of polymer material. The material is preferably produced by the method of introducing a shearing flow to a free surface in a predominantly monomeric solution of the self-assembling polymer sub-units, and inducing polymerization or growth of the monomer while in this shearing flow. The system for forming the oriented layer of material provides relative movement between a delivery system and the substrate on or over which the material is deposited. The rate of flow of the material from the delivery system and the relative velocity between the deposition surface and the material as it is delivered to the surface are controlled to properly orient the material at the desired thickness. These rates can be adjusted to vary the properties of the film in a controlled manner. Preferred embodiments include either angular or linear relative movement between the delivery system and the substrate.

Pva Hydrogel
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US Patent:

7235592, Jun 26, 2007
Filed:

Oct 12, 2004
Appl. No.:

10/962975
Inventors:

Orhun K. Muratoglu - Cambridge MA, US
Stephen H. Spiegelberg - Winchester MA, US
Jeffrey W. Ruberti - Lexington MA, US
Niels Abt - Winterthur, CH
Assignee:

Zimmer GmbH - Winterthur
International Classification:

C08F 2/46
US Classification:

522154, 522150, 522151, 522153, 522 86, 522 84, 522173, 522177, 522176, 522178, 522181, 522182, 522183, 525 50, 525 59, 525 56, 525 61, 524916
Abstract:

The present invention provides methods of making covalently crosslinked vinyl polymer hydrogels having advantageous physical properties, and covalently crosslinked vinyl polymer hydrogel compositions made by such methods, as well as articles of manufacture comprising such covalently crosslinked vinyl polymer hydrogel compositions. The physical properties of the produced hydrogels can be adjusted by varying controlled parameters such as the proportion of physical associations, the concentration of polymer and the amount of radiation applied. Such covalently crosslinked vinyl polymer hydrogels can be made translucent, preferably transparent, or opaque depending on the processing conditions. The stability of the physical properties of the produced vinyl polymer hydrogel can be enhanced by controlling the amount of covalent crosslinks.

Systems And Methods For Controlling And Forming Polymer Gels
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US Patent:

7485670, Feb 3, 2009
Filed:

Feb 4, 2004
Appl. No.:

10/771852
Inventors:

Jeffrey W. Ruberti - Lexington MA, US
Gavin J. C. Braithwaite - Cambridge MA, US
Assignee:

Cambridge Polymer Group, Inc. - Boston MA
International Classification:

A61L 27/52
A61L 27/16
US Classification:

5147722, 524557, 524916, 525 56, 525 61
Abstract:

In preferred embodiments, the present invention provides methods of controllably making a vinyl polymer hydrogel having desired physical properties without chemical cross links or radiation. The gelation process is modulated by controlling, for example, the temperature of a resultant vinyl polymer mixture having a gellant or using active ingredients provided in an inactive gellant complex. In accordance with a preferred embodiment, the method of manufacturing a vinyl polymer hyrodgel includes the steps of providing a vinyl polymer solution comprising a vinyl polymer dissolved in a first solvent; heating the vinyl polymer solution to a temperature elevated above the melting point of the physical associations of the vinyl polymer, mixing the vinyl polymer solution with a gellant, wherein the resulting mixture has a higher Flory interaction parameter than the vinyl polymer solution; inducing gelation of the mixture of vinyl polymer solution and gellant; and controlling the gelation rate to form a viscoelastic solution, wherein workability is maintained for a predetermined period, thereby making a vinyl polymer hydrogel having the desired physical property. In further preferred embodiments, the present invention provides physically crosslinked hydrogels produced by controlled gelation of viscoelastic solution wherein workability is maintained for a predetermined period. In another aspect, the present invention provides kits for use in repairing intervertebral disks or articulated joints including components that form the vinyl polymer hydrogel and a dispenser.

Systems And Methods For Controlling And Forming Polymer Gels
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US Patent:

7619009, Nov 17, 2009
Filed:

Aug 7, 2006
Appl. No.:

11/462799
Inventors:

Jeffrey W. Ruberti - Lexington MA, US
Gavin J. C. Braithwaite - Cambridge MA, US
Assignee:

Cambridge Polymer Group, Inc. - Boston MA
International Classification:

A61L 27/52
A61L 27/16
US Classification:

5147722, 524557, 524916, 525 56, 525 61, 128898, 424423
Abstract:

In preferred embodiments, the present invention provides methods of controllably making a vinyl polymer hydrogel having desired physical properties without chemical cross links or radiation. The gelation process is modulated by controlling, for example, the temperature of a resultant vinyl polymer mixture having a gellant or using active ingredients provided in an inactive gellant complex. In accordance with a preferred embodiment, the method of manufacturing a vinyl polymer hyrodgel includes the steps of providing a vinyl polymer solution comprising a vinyl polymer dissolved in a first solvent; heating the vinyl polymer solution to a temperature elevated above the melting point of the physical associations of the vinyl polymer, mixing the vinyl polymer solution with a gellant, wherein the resulting mixture has a higher Flory interaction parameter than the vinyl polymer solution; inducing gelation of the mixture of vinyl polymer solution and gellant; and controlling the gelation rate to form a viscoelastic solution, wherein workability is maintained for a predetermined period, thereby making a vinyl polymer hydrogel having the desired physical property. In further preferred embodiments, the present invention provides physically crosslinked hydrogels produced by controlled gellation of viscoelastic solution wherein workability is maintained for a predetermined period. In another aspect, the present invention provides kits for use in repairing intervertebral disks or articulated joints including components that form the vinyl polymer hydrogel and a dispenser.

Systems And Methods For Controlling And Forming Polymer Gels
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US Patent:

7745532, Jun 29, 2010
Filed:

Jul 31, 2003
Appl. No.:

10/631491
Inventors:

Jeffrey W. Ruberti - Lexington MA, US
Gavin J. C. Braithwaite - Cambridge MA, US
Assignee:

Cambridge Polymer Group, Inc. - Boston MA
International Classification:

C04B 24/26
C08G 73/06
US Classification:

524803, 524881
Abstract:

The preferred embodiments of the present invention provide polymer compositions and methods for controlling a property of a resultant gel. A preferred method includes dissolving a vinyl polymer in a first solvent to form a solution; and contacting the vinyl polymer solution in a suitable volume of at least one immersion solvent comprising a second solvent to cause gelation. In preferred embodiments, the invention provides poly(vinyl alcohol) compositions and methods that produce physically crosslinked hydrogels that have tunable physical properties. Also provided are articles of manufacture such as prosthetic intervertebral disks and contact lenses.

Systems And Methods For Controlling And Forming Polymer Hydrogels
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US Patent:

7776352, Aug 17, 2010
Filed:

Aug 7, 2006
Appl. No.:

11/462813
Inventors:

Jeffrey W. Ruberti - Lexington MA, US
Gavin J. C. Braithwaite - Cambridge MA, US
Assignee:

Cambridge Polymer Group, Inc. - Boston MA
International Classification:

A61M 5/19
A61J 1/10
US Classification:

424423, 424486, 516902, 524916
Abstract:

In preferred embodiments, the present invention provides methods of controllably making a vinyl polymer hydrogel having desired physical properties without chemical cross links or radiation. The gelation process is modulated by controlling, for example, the temperature of a resultant vinyl polymer mixture having a gellant or using active ingredients provided in an inactive gellant complex. In accordance with a preferred embodiment, the method of manufacturing a vinyl polymer hydrogel includes the steps of providing a vinyl polymer solution comprising a vinyl polymer dissolved in a first solvent; heating the vinyl polymer solution to a temperature elevated above the melting point of the physical associations of the vinyl polymer, mixing the vinyl polymer solution with a gellant, wherein the resulting mixture has a higher Flory interaction parameter than the vinyl polymer solution; inducing gelation of the mixture of vinyl polymer solution and gellant; and controlling the gelation rate to form a viscoelastic solution, wherein workability is maintained for a predetermined period, thereby making a vinyl polymer hydrogel having the desired physical property. In further preferred embodiments, the present invention provides physically crosslinked hydrogels produced by controlled gelation of viscoelastic solution wherein workability is maintained for a predetermined period. In another aspect, the present invention provides kits for use in repairing intervertebral disks or articulated joints including components that form the vinyl polymer hydrogel and a dispenser.

Pva Hydrogel
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US Patent:

7985781, Jul 26, 2011
Filed:

Jul 9, 2008
Appl. No.:

12/170303
Inventors:

Orhun K. Muratoglu - Cambridge MA, US
Stephen H. Spiegelberg - Winchester MA, US
Jeffrey W. Ruberti - Lexington MA, US
Niels A. Abt - Winterthur, CH
Assignee:

Zimmer GmbH
International Classification:

A61K 27/14
A61K 24/04
C08L 29/00
C08L 39/00
C08F 116/06
C08F 116/34
C08F 118/08
C08F 126/10
A61F 2/02
US Classification:

522 79, 522152, 522153, 522154, 522150, 522 86, 351160 R, 623 11, 623 142, 623 7, 623 8, 623 1111, 623 2358, 524803, 524808, 524818
Abstract:

The present invention provides methods of making covalently crosslinked vinyl polymer hydrogels having advantageous physical properties, and covalently crosslinked vinyl polymer hydrogel compositions made by such methods, as well as articles of manufacture comprising such covalently crosslinked vinyl polymer hydrogel compositions. The physical properties of the produced hydrogels can be adjusted by varying controlled parameters such as the proportion of physical associations, the concentration of polymer and the amount of radiation applied. Such covalently crosslinked vinyl polymer hydrogels can be made translucent, preferably transparent, or opaque depending on the processing conditions. The stability of the physical properties of the produced vinyl polymer hydrogel can be enhanced by controlling the amount of covalent crosslinks.

Collagen Fibrillar Construction
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US Patent:

8338570, Dec 25, 2012
Filed:

Oct 8, 2010
Appl. No.:

12/901286
Inventors:

Nima Saeidi - Allston MA, US
Jeffrey W. Ruberti - Lexington MA, US
Assignee:

Northeastern University - Boston MA
International Classification:

C07K 1/36
US Classification:

530356
Abstract:

Methods and compositions are described for organizing collagen into fibrillar networks, e. g, short and long-range organization. Collagen produced by the disclosed methods can be used for tissue engineering.