Jeffrey A Ness

US Patent:

6884586, Apr 26, 2005

Filed:

Jul 15, 2002

Appl. No.:

10/197616

Inventors:

Jeffrey Van Ness - Claremont CA, US
David J. Galas - Claremont CA, US
Lori K. Van Ness - Claremont CA, US

Assignee:

Keck Graduate Institute - Claremont CA

International Classification:

C12Q001/68

US Classification:

435 6

Abstract:

The present invention provides methods and compositions for nucleic acid methylation analysis using nicking agents.

US Patent:

7052846, May 30, 2006

Filed:

Jun 19, 2003

Appl. No.:

10/465524

Inventors:

Jeffrey Van Ness - Claremont CA, US
John C Tabone - Bothell WA, US
J Jeffry Howbert - Bellevue WA, US
John T Mulligan - Seattle WA, US

Assignee:

Operon Biotechnologies, Inc. - Huntsville AL

International Classification:

C12Q 1/68
C12P 19/34
C07H 21/00
C07H 21/02

US Classification:

435 6, 435 911, 435 912, 536 243, 536 2433

Abstract:

Tags and linkers specifically designed for a wide variety of nucleic acid reactions are disclosed, which are suitable for a wide variety of nucleic acid reactions wherein separation of nucleic acid molecules based upon size is required.

US Patent:

7112423, Sep 26, 2006

Filed:

Jul 15, 2002

Appl. No.:

10/197239

Inventors:

Jeffrey Van Ness - Claremont CA, US
David J Galas - Claremont CA, US
Lori K Van Ness - Claremont CA, US

Assignee:

Keck Graduate Institute - Claremont CA

International Classification:

C12P 19/34
C12Q 1/68
C07H 21/02
C07H 21/04

US Classification:

435 912, 435 6, 536 231

Abstract:

The present invention provides methods and kits for amplifying target nucleic acids (including whole genomes) using nicking agents. In certain aspects, the amplification does not require the use of any external oligonucleotide primers that are capable of annealing to a portion of the target nucleic acid. This invention is useful in many areas such as genetic disease diagnoses, forensic analyses and palcoarcheological studies.

US Patent:

7192583, Mar 20, 2007

Filed:

Mar 6, 2003

Appl. No.:

10/384893

Inventors:

Mary E Brunkow - Seattle WA, US
David J Galas - Claremont CA, US
Brian Kovacevich - Renton WA, US
John T Mulligan - Seattle WA, US
Bryan W Paeper - Seattle WA, US
Jeffrey Van Ness - Claremont CA, US
David G Winkler - Seattle WA, US

Assignee:

Darwin Discovery Ltd. - Bothell WA

International Classification:

A61K 39/395

US Classification:

4241391, 4241331, 4241351, 4241411, 4241451, 5303879, 5303881, 53038824

Abstract:

Antibodies to a novel family of TGF-β binding proteins are disclosed, for use in methods of altering bone density and bone mineralization, which methods are applicable to the treatment of diseases including osteopenia and osteoporosis.

US Patent:

7247434, Jul 24, 2007

Filed:

Jul 16, 2003

Appl. No.:

10/622182

Inventors:

Jeffrey Van Ness - Claremont CA, US
John C Tabone - Bothell WA, US
J Jeffry Howbert - Bellevue WA, US
John T Mulligan - Seattle WA, US

Assignee:

Operon Biotechnologies, Inc. - Huntsville AL

International Classification:

C12Q 1/68
G01N 33/53
G01N 33/543
G01N 33/536
C07H 21/00
C07H 21/02

US Classification:

435 6, 435 71, 435 72, 436518, 436536, 536 231, 536 243, 536 2433

Abstract:

Methods and compounds, including compositions therefrom, are provided for determining the sequence of nucleic acid molecules. The methods permit the determination of multiple nucleic acid sequences simultaneously. The compounds are used as tags to generate tagged nucleic acid fragments which are complementary to a selected target nucleic acid molecule. Each tag is correlative with a particular nucleotide and, in a preferred embodiment, is detectable by mass spectrometry. Following separation of the tagged fragments by sequential length, the tags are cleaved from the tagged fragments. In a preferred embodiment, the tags are detected by mass spectrometry and the sequence of the nucleic acid molecule is determined therefrom. The individual steps of the methods can be used in automated format, e. g. , by the incorporation into systems.

US Patent:

7572899, Aug 11, 2009

Filed:

Mar 7, 2002

Appl. No.:

10/095248

Inventors:

Mary E Brunkow - Seattle WA, US
David J Galas - Claremont CA, US
Brian Kovacevich - Renton WA, US
John T Mulligan - Seattle WA, US
Bryan Paeper - Seattle WA, US
Jeffrey Van Ness - Claremont CA, US
David G Winkler - Seattle WA, US

Assignee:

UCB SA - Berkshire

International Classification:

C07H 21/04
C12N 15/00

US Classification:

536 231, 536 232, 4353201, 4352523, 43525411, 435325, 435419, 435 691

Abstract:

Nucleic acids relating to human TGF-β binding proteins are disclosed. Also disclosed are assays for selecting molecules for increasing bone mineralization and methods for utilizing such molecules.

US Patent:

7642344, Jan 5, 2010

Filed:

Jun 21, 2007

Appl. No.:

11/821531

Inventors:

Jeffrey Van Ness - Claremont CA, US
John C Tabone - Bothell WA, US
J Jeffry Howbert - Bellevue WA, US
John T Mulligan - Seattle WA, US

Assignee:

Operon Biotechnologies, Inc. - Huntsville AL

International Classification:

C07H 21/00
C07H 21/02
C07H 19/04
C12Q 1/68

US Classification:

536 231, 536 253, 536 266, 435 6

Abstract:

Methods and compounds, including compositions therefrom, are provided for determining the sequence of nucleic acid molecules. The methods permit the determination of multiple nucleic acid sequences simultaneously. The compounds are used as tags to generate tagged nucleic acid fragments which are complementary to a selected target nucleic acid molecule. Each tag is correlative with a particular nucleotide and, in a preferred embodiment, is detectable by mass spectrometry. Following separation of the tagged fragments by sequential length, the tags are cleaved from the tagged fragments. In a preferred embodiment, the tags are detected by mass spectrometry and the sequence of the nucleic acid molecule is determined therefrom. The individual steps of the methods can be used in automated format, e. g. , by the incorporation into systems.

US Patent:

7758858, Jul 20, 2010

Filed:

Feb 27, 2004

Appl. No.:

10/788606

Inventors:

Mary E Brunkow - Seattle WA, US
David J Galas - Claremont CA, US
Brian Kovacevich - Renton WA, US
John T Mulligan - Seattle WA, US
Bryan W Paeper - Seattle WA, US
Jeffrey Van Ness - Claremont CA, US
David G Winkler - Seattle WA, US

Assignee:

Darwin Discovery Ltd. - Bothell WA

International Classification:

C07K 16/00
A61K 39/395
C12N 15/00

US Classification:

4241301, 5303871, 5303881, 53038823, 5303891, 5303892, 4241781, 435 693

Abstract:

Compositions and methods for increasing bone density using antibodies directed to a novel class or family of TGF-β binding proteins are provided. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases associated with a loss of bone density, for example osteoporosis.