Michael Terence Black - Chester Springs PA Christine Debouck - Wayne PA Jason Craig Fedon - Strafford PA John Edward Hodgson - Malvern PA Deborah Dee Jaworski - Norristown PA David Justin Charles Knowles - Boroughbridge, GB Anna Lisa Kosmatka - Doylestown PA Jeffrey Mooney - Limerick PA Richard Oakley Nicholas - Collegeville PA Leslie Marie Palmer - Audubon PA Lisa Kathleen Shilling - Newtown PA Robert King Stodola - Flourtown PA Min Wang - Blue Bell PA Richard Lloyd Warren - Blue Bell PA Yi Yi Zhong - Audubon PA
Assignee:
SmithKline Beecham Corporation - Phialdelphia PA SmithKline Beecham PLC
The invention provides ribG polypeptides and polynucleotides encoding ribG polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribG polypeptides to screen for antibacterial compounds.
Alison Francis Chalker - Trappe PA Christine Debouck - Wayne PA David John Holmes - West Chester PA Karen Anne Ingraham - Auburn PA Deborah Dee Jaworski - West Chester PA Anna Lisa Kosmatka - Doylestown PA Damien McDevitt - Berwyn PA Jeffrey Mooney - Limerick PA Stewart C Pearson - Berwyn PA Chi Yong So - Havertwon PA Nicola Gail Wallis - Wayne PA Min Wang - Blue Bell PA Richard Lloyd Warren - Blue Bell PA Yi Yi Zhong - Audubon PA
The invention provides FabG polypeptides and polynucleotides encoding FabG polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing FabG polypeptides to screen for antibacterial compounds.
Karen M ODwyer - Phoenixville PA Deborah D Jaworski - Norristown PA Jeffrey L Mooney - Limerick PA Lisa K Shilling - Newtown PA John Peter Throup - Royersford PA Nicola Gail Wallis - Wayne PA Yi Yi Zhong - Audubon PA Min Wang - Blue Bell PA
Assignee:
SmithKline Beecham Corporation - Philadelphia PA
International Classification:
C12N 912
US Classification:
435194, 4352523, 4353201, 435 6, 530350
Abstract:
The invention provides Histidine Kinase polypeptides and polynucleotides encoding Histidine Kinase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Histidine Kinase polypeptides to screen for antibacterial compounds.
Christine Debouck - Wayne PA Daniel Robert Gentry - Pottstown PA Deborah Dee Jaworski - West Chester PA John Timothy Londsdale - Exton PA Jeffrey L Mooney - Limerick PA David John Payne - Phoenixville PA Stewart Campbell Pearson - Berwyn PA Lisa Kathleen Schilling - Newtown PA Glenn Scott Van Aller - Reading PA Min Wang - Blue Bell PA Yi Yi Zhong - Collegeville PA
Assignee:
SmithKline Beecham Corporation - Philadelphia PA
International Classification:
C12N 910
US Classification:
435193, 4353201, 435325, 4352523, 536 232
Abstract:
The invention provides FabH polypeptides and polynucleotides encoding FabH polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing FabH polypeptides to screen for antibacterial compounds.
Sanjoy Biswas - Paoli PA, US James Raymond Brown - Berwyn PA, US Christine Debouck - Wayne PA, US Deborah Dee Jaworski - West Chester PA, US Elizabeth Jane Lawlor - Paris, FR Jeffrey Mooney - Limerick PA, US Lisa Kathleen Shilling - Newtown PA, US Min Wang - Blue Bell PA, US Richard Lloyd Warren - Blue Bell PA, US Magdalena Zalacain - West Chester PA, US Yi Yi Zhong - Audobon PA, US John Peter Throup - Royersford PA, US Karen Anne Ingraham - Auburn PA, US Alison Frances Chalker - Trappe PA, US David John Holmes - West Chester PA, US Christopher Michael Traini - Media PA, US
Assignee:
SmithKline Beecham Corporation - Philadelphia PA
International Classification:
C12N 9/14 C12N 9/16
US Classification:
435195, 435196, 530350
Abstract:
The invention provides pth polypeptides and polynucleotides encoding pth polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing pth polypeptides to screen for antibacterial compounds.
Derk Bergsma - Berwyn PA, US Nabil Elshourbagy - West Chester PA, US Pamela Lane - Norristown PA, US Xiaotong Li - Devon PA, US Jeffrey Mooney - Limerick PA, US Ping Tsui - Berwyn PA, US
Human H218 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Human H218 polypeptides and polynucleotides in therapy, and diagnostic assays for such.
Sanjoy Biswas - Paoli PA, US James Brown - Berwyn PA, US Christine Debouck - Wayne PA, US Deborah Jaworski - West Chester PA, US Elizabeth Lawlor - Paris, FR Jeffrey Mooney - Limerick PA, US Lisa Shilling - Newtown PA, US Min Wang - Blue Bell PA, US Richard Warren - Blue Bell PA, US Magdalena Zalacain - West Chester PA, US Yi Yi Zhong - Audobon PA, US John Throup - Royersford PA, US Karen Ingraham - Auburn PA, US Alison Chalker - Trappe PA, US David Holmes - West Chester PA, US Christopher Traini - Media PA, US
International Classification:
C12P021/02 C07H021/04 C12N005/06
US Classification:
536/023500, 435/069100, 435/325000
Abstract:
The invention provides pth polypeptides and polynucleotides encoding pth polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing pth polypeptides to screen for antibacterial compounds.
Methods For Identifiying Genes Essential To The Growth Of An Organism
The present invention provides methods for identifying genes essential to the growth of an organism using a grid prepared from a genomic library of a selected organism. Genes identified as essential by this method and proteins encoded thereby are also provided. In addition, methods of using these genes and proteins encoded thereby are disclosed.