Jeffrey R Ammann

Address:

2645 Wendover Rd, Parkville, MD 21234

Phone:

410 661-3316

VIN:

1N4AL21E77N415434

Make:

NISSAN

Model:

ALTIMA

Year:

2007

US Patent:

20040015015, Jan 22, 2004

Filed:

Mar 3, 2003

Appl. No.:

10/376311

Inventors:

Jeffrey Ammann - Round Lake IL, US

International Classification:

C07C211/27

US Classification:

564/366000

Abstract:

Disclosed herein are trifluoromethylepinephrine compounds having the following structural formula (I) wherein R-Rare each independently selected from the group consisting of H, alkyl, alkoxyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, acyl, thioacyl, sulfonyl mercapto, alkylthio, carboxy, amino, alkylamino dialkylamino, carbamoyl, arylthio, and heteroarylthio; wherein X, Y, and Z are each independently selected from the group consisting of H or trifluoromethyl with the proviso that at least one of which is trifluoromethyl. Also disclosed are pharmaceutical compositions comprising the trifluoromethylepinephrine compounds and methods of making and using thereof. Novel trifluoroepinephrine intermediates are also disclosed.