Jee Hyung Lee

US Patent:

7745164, Jun 29, 2010

Filed:

Dec 26, 2006

Appl. No.:

11/645056

Inventors:

Wei Liu - Lexington MA, US
Bradley A. Ozenberger - Olney MD, US
Leeying Wu - Lexington MA, US
Ching-Hsiung Frederick Lo - Pennington NJ, US
Steven A. Haney - Concord MA, US
Hemchand Sookdeo - Natick MA, US
Jee Hyung Lee - Boston MA, US

Assignee:

Wyeth LLC - Madison NJ

International Classification:

C12Q 1/48

US Classification:

435 15

Abstract:

The invention provides isolated protein kinase polypeptides related to novel brain-localized protein kinases homologous to known homeodomain-interacting protein kinases (HIPKs), isolated nucleic acid molecules that encode these polypeptides, inhibitors, and methods related thereto. The novel polypeptides and nucleic acid molecules of the invention are termed HIPK4. The invention also provides genetically engineered expression vectors, host cells, and transgenic animals comprising the novel nucleic acid molecules of the invention. The invention additionally provides antisense and RNAi molecules to the nucleic acid molecules of the invention, as well as inhibitors, activators, and antibodies capable of binding to the protein kinase polypeptides of the invention. The invention further provides uses of HIPK4 and its inhibitors, e. g. , mutants of HIPK4 lacking protein kinase activity, for modulation of apoptosis, as well as the prevention and treatment of neurological disorders and cancers.

US Patent:

20040248168, Dec 9, 2004

Filed:

Mar 25, 2004

Appl. No.:

10/808522

Inventors:

Wei Liu - Sudbury MA, US
Bradley Ozenberger - Olney MD, US
Leeying Wu - Lexington MA, US
Ching-Hsiung Lo - Pennington NJ, US
Steven Haney - Concord MA, US
Hemchand Sookdeo - Natick MA, US
Jee Lee - Boston MA, US

International Classification:

C12Q001/68
C07H021/04
C12N009/12

US Classification:

435/006000, 435/069100, 435/194000, 435/320100, 435/325000, 536/023200

Abstract:

The invention provides isolated protein kinase polypeptides related to novel brain-localized protein kinases homologous to known homeodomain-interacting protein kinases (HIPKs), and the isolated nucleic acid molecules that encode these polypeptides. The novel polypeptides and nucleic acid molecules of the invention are termed HIPK4. The invention also provides genetically engineered expression vectors, host cells, and transgenic animals comprising the novel nucleic acid molecules of the invention. The invention additionally provides antisense and RNAi molecules to the nucleic acid molecules of the invention. The invention further provides inhibitors, activators, and antibodies capable of binding to the protein kinase polypeptides of the invention, and their use in the prevention and treatment of neurological disorders.