Jay L Zweier

US Patent:

7662362, Feb 16, 2010

Filed:

Sep 7, 2004

Appl. No.:

10/935297

Inventors:

Periannan Kuppusamy - New Albany OH, US
Ramasamy P. Pandian - Columbus OH, US
Narasimham L. Parinandi - Upper Arlington OH, US
Jay L. Zweier - Blacklick OH, US

Assignee:

The Ohio State University Research Foundation - Columbus OH

International Classification:

A61B 5/055
C07B 47/00
C07D 487/22

US Classification:

424 93, 540145

Abstract:

A new class of micro- and nano-particulate paramagnetic spin probes especially useful for magnetic resonance imaging techniques, including electron paramagnetic resonance (EPR) and magnetic resonance imaging (MRI). The probes are lithium phthalocyanine derivative compounds. Also provided are suspensions and emulsions comprising lithium phthalocyanine derivative probes. Also provided are noninvasive methods for measuring noninvasive methods of measuring oxygen concentration, oxygen partial pressure, oxygen metabolism, and nitric oxide concentration in a specific tissue, organ, or cell in vivo or in vitro.

US Patent:

8066973, Nov 29, 2011

Filed:

Mar 1, 2006

Appl. No.:

11/365798

Inventors:

Periannan Kuppusamy - New Albany OH, US
Vijay Kutala - Columbus OH, US
Jay L. Zweier - Columbus OH, US
Pawel Kwiatkowski - Dublin OH, US

Assignee:

The Ohio State University Research Foundation - Columbus OH

International Classification:

C07B 47/00
C07F 487/22
A61B 5/055

US Classification:

424 93, 540145

Abstract:

A new class of micro- and nano- particulate paramagnetic spin probes useful for magnetic resonance imaging techniques, including electron paramagnetic resonance (EPR) and magnetic resonance imaging (MRI). The probes are lithium phthalocyanine derivative compounds. Also provided are suspensions and emulsions comprising lithium phthalocyanine derivative probes. Also provided are noninvasive methods for measuring noninvasive methods of measuring oxygen concentration, oxygen partial pressure, oxygen metabolism, and nitric oxide concentration in a specific tissue, organ, or cell in vivo or in vitro.

US Patent:

8568694, Oct 29, 2013

Filed:

Jan 15, 2010

Appl. No.:

12/688767

Inventors:

Periannan Kuppusamy - New Albany OH, US
Ramasamy P. Pandian - Columbus OH, US
Narasimham L. Parinandi - Upper Arlington OH, US
Jay L. Zweier - Blacklick OH, US

Assignee:

The Ohio State University Research Foundation - Columbus OH

International Classification:

A61B 5/055
C07B 47/00
C07D 487/22

US Classification:

424 93, 424 961, 540145

Abstract:

A new class of micro- and nano-particulate paramagnetic spin probes especially useful for magnetic resonance imaging techniques, including electron paramagnetic resonance (EPR) and magnetic resonance imaging (MRI). The probes are lithium phthalocyanine derivative compounds. Also provided are suspensions and emulsions comprising lithium phthalocyanine derivative probes. Also provided are noninvasive methods for measuring noninvasive methods of measuring oxygen concentration, oxygen partial pressure, oxygen metabolism, and nitric oxide concentration in a specific tissue, organ, or cell in vivo or in vitro.

US Patent:

8569482, Oct 29, 2013

Filed:

Nov 29, 2011

Appl. No.:

13/306565

Inventors:

Periannan Kuppusamy - Columbus OH, US
Vijay Kutala - Columbus OH, US
Jay L. Zweier - Columbus OH, US
Pawel Kwiatkowski - Dublin OH, US

Assignee:

The Ohio State University Research Foundation - Columbus OH

International Classification:

C09B 47/04

US Classification:

540139

Abstract:

A new class of micro- and nano-particulate paramagnetic spin probes useful for magnetic resonance imaging techniques, including electron paramagnetic resonance (EPR) and magnetic resonance imaging (MRI). The probes are lithium phthalocyanine derivative compounds. Also provided are suspensions and emulsions comprising lithium phthalocyanine derivative probes. Also provided are noninvasive methods for measuring noninvasive methods of measuring oxygen concentration, oxygen partial pressure, oxygen metabolism, and nitric oxide concentration in a specific tissue, organ, or cell in vivo or in vitro.

US Patent:

20060276530, Dec 7, 2006

Filed:

Nov 23, 2005

Appl. No.:

11/286682

Inventors:

Frederick Villamena - Columbus OH, US
Christopher Hadad - Dublin OH, US
Jay Zweier - Blacklick OH, US

International Classification:

A61K 31/4015
G01N 37/00
C07D 207/24

US Classification:

514423000, 548537000, 436056000

Abstract:

Provided are spin traps for the study of radical formation in vivo or in vitro. 5-carbamoyl-5-methyl-1-pyrroline N-oxide (AMPO) and 2-amino-5-carbamoyl-5-methyl-1-pyrroline N-oxide (NH-AMPO), have the following structures, respectively: as well as salts thereof.

US Patent:

20100284928, Nov 11, 2010

Filed:

Jan 2, 2009

Appl. No.:

12/811292

Inventors:

Subha V. Raman - Columbus OH, US
Orlando P. Simonetti - Columbus OH, US
Jay L. Zweier - Blacklick OH, US

Assignee:

THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION - Columbus OH

International Classification:

A61K 49/06
A61K 49/00
A61B 5/055
G06K 9/00

US Classification:

424 93, 424 91, 600411, 382131

Abstract:

Methods and uses of in vivo atherosclerotic plaque characterization in a subject in need thereof, that include detecting a level of one or more iron complexes in plaque in the subject, and comparing detected level to a known value determined from subjects without an atherosclerotic condition are disclosed.

US Patent:

20140170073, Jun 19, 2014

Filed:

Aug 30, 2013

Appl. No.:

14/015363

Inventors:

- Columbus OH, US
Ramasamy P. Pandian - Columbus OH, US
Narasimham L. Parinandi - Upper Arlington OH, US
Jay L. Zweier - Blacklick OH, US

Assignee:

The Ohio State University Research Foundation - Columbus OH

International Classification:

A61K 49/10
C07F 1/02

US Classification:

424 93, 540139

Abstract:

A new class of micro- and nano-particulate paramagnetic spin probes especially useful for magnetic resonance imaging techniques, including electron paramagnetic resonance (EPR) and magnetic resonance imaging (MRI). The probes are lithium phthalocyanine derivative compounds. Also provided are suspensions and emulsions comprising lithium phthalocyanine derivative probes. Also provided are noninvasive methods for measuring noninvasive methods of measuring oxygen concentration, oxygen partial pressure, oxygen metabolism, and nitric oxide concentration in a specific tissue, organ, or cell in vivo or in vitro.

Author:

Jay L. Zweier

ISBN #:

0792383893