Jan Robert Groen

Author:

Jan Groen

ISBN #:

9060094476

Author:

Jan Groen

ISBN #:

9060095391

Author:

Jan Groen

ISBN #:

9290211962

Author:

Jan de Groen

ISBN #:

9066302496

US Patent:

8318423, Nov 27, 2012

Filed:

Jul 6, 2004

Appl. No.:

10/886517

Inventors:

Lilly I Kong - Covina CA, US
Jan Groen - Laguna Niguel CA, US

Assignee:

Focus Diagnostics, Inc. - Herndon VA

International Classification:

C12Q 1/68

US Classification:

435 61, 435 5

Abstract:

The invention provides methods and compositions for rapid, sensitive, and highly specific nucleic acid-based (e. g. , DNA based) detection of human rhinovirus (HRV) in a sample. In general, the methods involve detecting a target nucleic acid having a target sequence of a conserved 5′ untranslated region of the HRV genome. The invention also features compositions, including primers, probes, and kits, for use in the methods of the invention.

US Patent:

20050053919, Mar 10, 2005

Filed:

Nov 25, 2003

Appl. No.:

10/722045

Inventors:

Jan De Jong - Gouda, NL
Ronaldus Fouchier - Rotterdam, NL
Bernadetta Van Den Hoogen - Rotterdam, NL
Albertus Dominicus Marcellinus Osterhaus - Bunnik, NL
Jan Groen - Laguna Niguel CA, US

International Classification:

C12Q001/70
C12N005/16
A61K039/42
C12N007/02
C12N007/00
C12N015/63
C12N015/09
C12N015/74
C12N005/06
G01N033/53
C07H021/04
C12Q001/68
A61K039/155
C12N015/70
C12N015/00
C12N007/01

US Classification:

435005000, 435006000, 435007100, 435320100, 435235100, 435239000, 435339000, 536023720, 424159100, 424211100

Abstract:

The invention relates to the field of virology. The invention provides an isolated essentially mammalian negative-sense single stranded RNA virus (MPV) within the subfamily of the family and identifiable as phylogenetically corresponding to the genus and components thereof.

US Patent:

20050118195, Jun 2, 2005

Filed:

Jan 18, 2002

Appl. No.:

10/466811

Inventors:

Jan De Jong - Gouda, NL
Ronaldus Fouchier - Rotterdam, NL
Bernadetta Van Den Hoogen - Rotterdam, NL
Albertus Dominicus Marcellinus Osterhaus - Bunnik, NL
Jan Groen - Laguna Niguel CA, US

International Classification:

C12Q001/70
C07H021/02
C12N007/00
A61K039/12

US Classification:

424204100, 435235100, 514044000, 435005000, 536023720, 530388300

Abstract:

The invention relates to the field of virology. The invention provides an isolated essentially mammalian negative-sense single stranded RNA virus (MPV) within the sub-family Pneumovirinae of the family Paramyxoviridae and identifiable as phylogenetically corresponding to the genus and components thereof.

US Patent:

20090246855, Oct 1, 2009

Filed:

Sep 18, 2008

Appl. No.:

12/284347

Inventors:

Ronaldus Adrianus Maria Fouchier - Rotterdam, NL
Bernadetta Gerarda Van Den Hoogen - Rotterdam, NL
Albertus Dominicus Marcellinus Erasmus Osterhaus - Bunnik, NL
Jan Cornelius De Jong - Gouda, NL
Jan Groen - Laguna Niguel CA, US

International Classification:

C12N 7/04
C07H 21/04
C12N 7/00

US Classification:

435236, 536 231, 4352351

Abstract:

The present invention provides an isolated mammalian negative strand RNA virus, metapneumovirus (MPV), within the sub-family Pneumoviridae, of the family Paramyxoviridae. The invention also provides isolated mammalian negative strand RNA viruses identifiable as phylogenetically corresponding or relating to the genus Metapneumovirus and components thereof. In particular the invention provides a mammalian MPV, subgroups and variants thereof. The invention relates to genomic nucleotide sequences of different isolates of mammalian metapneumoviruses, in particular human metapneumoviruses. The invention relates to the use of the sequence information of different isolates of mammalian metapneumoviruses for diagnostic and therapeutic methods. The present invention relates to nucleotide sequences encoding the genome of a metapneumovirus or a portion thereof, including both mammalian and avian metapneumovirus. The invention further encompasses chimeric or recombinant viruses encoded by said nucleotide sequences. The invention also relates to chimeric and recombinant mammalian MPV that comprise one or more non-native or heterologous sequences. The invention further relates to vaccine formulations comprising mammalian or avian metapneumovirus, including recombinant and chimeric forms of said viruses. The vaccine preparations of the invention encompass multivalent vaccines, including bivalent and trivalent vaccine preparations.

US Patent:

7449324, Nov 11, 2008

Filed:

Feb 21, 2003

Appl. No.:

10/371099

Inventors:

Ronaldus Adrianus Maria Fouchier - Rotterdam, NL
Bernadetta Gerarda Van Den Hoogen - Rotterdam, NL
Albertus Dominicus Marcellinus Erasmus Osterhaus - Antwerp, BE
Jan Cornelius De Jong - Gouda, NL
Jan Groen - Laguna Niguel CA, US

Assignee:

ViroNovative BV - Rotterdam
MedImmune, LLC - Gaithersburg MD

International Classification:

C12N 7/02

US Classification:

435239

Abstract:

The present invention provides an isolated mammalian negative strand RNA virus, metapneumovirus (MPV), within the sub-family Pneumoviridae, of the family Paramyxoviridae. The invention also provides isolated mammalian negative strand RNA viruses identifiable as phylogenetically corresponding or relating to the genus Metapneumovirus and components thereof. In particular the invention provides a mammalian MPV, subgroups and variants thereof. The invention relates to genomic nucleotide sequences of different isolates of mammalian metapneumoviruses, in particular human metapneumoviruses. The invention relates to the use of the sequence information of different isolates of mammalian metapneumoviruses for diagnostic and therapeutic methods. The present invention relates to nucleotide sequences encoding the genome of a metapneumovirus or a portion thereof, including both mammalian and avian metapneumovirus. The invention further encompasses chimeric or recombinant viruses encoded by said nucleotide sequences.

US Patent:

20180216200, Aug 2, 2018

Filed:

Mar 29, 2018

Appl. No.:

15/940432

Inventors:

- Rotterdam, NL
Bernadetta Gerarda Van Den Hoogen - Rotterdam, NL
Albertus Dominicus Marcellinus Erasmus Osterhaus - Antwerpen, BE
Jan Cornelius De Jong - Gouda, NL
Jan Groen - Laguna Niguel CA, US

Assignee:

Erasmus University Medical Center Rotterdam - Rotterdam

International Classification:

C12Q 1/70
G01N 33/569
A61K 39/155
C07K 14/005
C07K 16/10
C12N 7/00
C12N 15/86
G01N 33/50
A61K 39/12
A61K 39/00

Abstract:

Provided is an isolated mammalian negative strand RNA virus, metapneumovirus (MPV), within the sub-family Pneumoviridae, of the family Paramyxoviridae. Also provided are isolated mammalian negative strand RNA viruses identifiable as phylogenetically corresponding or relating to the genus Metapneumovirus and components thereof. In particular, provided is a mammalian MPV, subgroups and variants thereof. Also provided are genomic nucleotide sequences of different isolates of mammalian MPV, in particular, human MPV. Disclosed is the use of the sequence information of different isolates of mammalian MPV for diagnostic and therapeutic methods. Provided are nucleotide sequences encoding the genome of an MPV or a portion thereof, including both mammalian and avian MPV. Further described are chimeric or recombinant viruses encoded by the nucleotide sequences and chimeric and recombinant mammalian MPV that comprise one or more non-native or heterologous sequences. Also provided are vaccine formulations comprising mammalian or avian MPV, including recombinant and chimeric forms thereof. The vaccine preparations encompass multivalent vaccines, including bivalent and trivalent vaccine preparations.

US Patent:

20180057894, Mar 1, 2018

Filed:

Nov 6, 2017

Appl. No.:

15/804585

Inventors:

- Rotterdam, NL
Bernadetta Gerarda Van Den Hoogen - Rotterdam, NL
Albertus Dominicus Marcellinus Erasmus Osterhaus - Antwerpen, BE
Jan Cornelius De Jong - Gouda, NL
Jan Groen - Laguna Niguel CA, US

Assignee:

Erasmus University Medical Center Rotterdam - Rotterdam

International Classification:

C12Q 1/70
G01N 33/569
A61K 39/155
C07K 14/005
C07K 16/10
C12N 7/00
C12N 15/86
G01N 33/50
A61K 39/12
A61K 39/00

Abstract:

Provided is an isolated mammalian negative strand RNA virus, (MPV), within the sub-family Pneumoviridae, of the family Paramyxoviridae. Also provided are isolated mammalian negative strand RNA viruses identifiable as phylogenetically corresponding or relating to the genus and components thereof. In particular, provided is a mammalian MPV, subgroups and variants thereof. Also provided are genomic nucleotide sequences of different isolates of mammalian MPV, in particular, human MPV. Disclosed is the use of the sequence information of different isolates of mammalian MPV for diagnostic and therapeutic methods. Provided are nucleotide sequences encoding the genome of an MPV or a portion thereof, including both mammalian and avian MPV. Further described are chimeric or recombinant viruses encoded by the nucleotide sequences and chimeric and recombinant mammalian MPV that comprise one or more non-native or heterologous sequences. Also provided are vaccine formulations comprising mammalian or avian MPV, including recombinant and chimeric forms thereof. The vaccine preparations encompass multivalent vaccines, including bivalent and trivalent vaccine preparations.

US Patent:

20170183747, Jun 29, 2017

Filed:

Mar 8, 2017

Appl. No.:

15/453764

Inventors:

- Rotterdam, NL
Ronaldus Adrianus Maria Fouchier - Rotterdam, NL
Jan Groen - Laguna Niguel CA, US
Albertus Dominicus Marcellinus Erasmus Osterhaus - Antwerpen, BE
Bernadetta Gerarda Van Den Hoogen - Rotterdam, NL

Assignee:

Erasmus University Medical Center Rotterdam - Rotterdam

International Classification:

C12Q 1/70

Abstract:

The invention relates to the field of virology. The invention provides an isolated essentially mammalian negative-sense single-stranded RNA virus (MPV) within the subfamily Pneumovirinae of the family Paramyxoviridae and identifiable as phylogenetically corresponding to the genus Metapneumovirus and components thereof.