Allen D. Roses - Durham NC Warren J. Strittmatter - Durham NC Guy S. Salvesen - Chapel Hill NC Jan Enghild - Durham NC Donald E. Schmechel - Durham NC
Assignee:
Duke University - Durham NC
International Classification:
C12Q 168 C12Q 100 C12P 1934
US Classification:
435 6
Abstract:
Methods of diagnosing or prognosing Alzheimer's disease in a subject are disclosed. The methods involve directly or indirectly detecting the presence or absence of an apolipoprotein E type 4 (ApoE4) isoform or DNA, encoding ApoE4 in the subject. The presence of ApoE4 indicates the subject is afflicted with Alzheimer's disease or at risk of developing Alzheimer's disease. A novel immunochemical assay for detecting the presence or absence of the Apoliprotein E (ApoE) E4 allele in a subject is also disclosed.
Apolipoprotein E Isoform-Specific Monoclonal Antibodies
Allen D. Roses - Durham NC Warren J. Strittmatter - Durham NC Guy S. Salvesen - Chapel Hill NC Jan Enghild - Durham NC Donald E. Schmechel - Durham NC
Assignee:
Duke University - Durham NC
International Classification:
C07K 1600
US Classification:
53038825
Abstract:
Methods of diagnosing or prognosing Alzheimer's disease in a subject are disclosed. The methods involve directly or indirectly detecting the presence or absence of an apolipoprotein E type 4 (ApoE4) isoform or DNA encoding ApoE4 in the subject. The presence of ApoE4 indicates the subject is afflicted with Alzheimer's disease or at risk of developing Alzheimer's disease. A novel immunochemical assay for detecting the presence or absence of the Apoliprotein E (ApoE) E4 allele in a subject is also disclosed.
Allen D. Roses - Durham NC Warren J. Strittmatter - Durham NC Guy S. Salvesen - Chapel Hill NC Jan Enghild - Durham NC Donald E. Schmechel - Durham NC
Assignee:
Duke University - Durham NC
International Classification:
C12Q 168 G01N 3353 C12P 1934 C07H 2102
US Classification:
435 6
Abstract:
Methods of diagnosing or prognosing Alzheimer's disease in a subject are disclosed. The methods involve directly or indirectly detecting the presence or absence of an apolipoprotein E type 4 (ApoE4) isoform or DNA encoding ApoE4 in the subject. The presence of ApoE4 indicates the subject is afflicted with Alzheimer's disease or at risk of developing Alzheimer's disease. A novel immunochemical assay for detecting the presence or absence of the Apoliprotein E (ApoE) E4 allele in a subject is also disclosed.
Kit For Detecting The Apoe4 Allele, And For Diagnosing The Existence Or Risk Of Developing Alzheimer's Disease
Allen D. Roses - Durham NC Warren J. Strittmatter - Durham NC Guy S. Salvesen - Chapel Hill NC Jan Enghild - Durham NC Donald E. Schmechel - Durham NC
Assignee:
Duke University - Durham NC
International Classification:
C12Q 168 G01N 3353
US Classification:
435 6
Abstract:
Methods of diagnosing or prognosing Alzheimer's disease in a subject are disclosed. The methods involve directly or indirectly detecting the presence or absence of an apolipoprotein E type 4 (ApoE4) isoform or DNA encoding ApoE4 in the subject. The presence of ApoE4 indicates the subject is at risk of developing Alzheimer's disease. A novel immunochemical assay for detecting the presence or absence of the Apoliprotein E (ApoE) E4 allele in a subject is also disclosed.
Method To Screen Compounds That Affect Gapdh Binding To Polyglutamine
James R. Burke - Chapel Hill NC Jeffery M. Vance - Durham NC Jan Enghild - Durham NC Warren J. Strittmatter - Durham NC
Assignee:
Duke University - Durham NC
International Classification:
G01N 3368
US Classification:
435 71
Abstract:
GAPDH binds to expanded polyglutamine regions which are found in proteins encoded by genes with CAG repeat domains, which genes cause inherited neurodegenerative disorders and are associated with certain psychiatric disorders. Therapeutic methods are based on inhibiting the binding of GAPDH to expanded polyglutamine regions. A method of screening compounds for the ability to inhibit binding of GAPDH to polyglutamine regions is described.
Jan J. Enghild - Durham NC Tim D. Oury - Wexford PA Ida B. Thogersen - Durham NC Zuzana Valnickova - Durham NC Philip J. Walther - Durham NC
Assignee:
Duke University - Durham NC
International Classification:
G01N 33574 A61K 3804 C07K 1600 C07K 1700 C07K 500
US Classification:
435 723
Abstract:
Dectection of secreted Prostate Specific Antigen (PSA) by detecting the presence of an N-terminal activation peptide of PSA in a biological sample is described. The method may be used in screening for or diagnosing disease states associated with increased levels of secreted prostate specific antigen.