James K Presnail from Saint Louis, MO, age 63

Resumes

Chief Operational Officer

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Location:

8025 Bonhomme Ave, Saint Louis, MO 63105

Industry:

Biotechnology

Work:

Lavie Bio
Chief Operational Officer
Calyxt
Director of Molecular Biology and Analytics
Dupont 1995 - Jan 2015
Senior Research Manager
Evogene 1995 - Jan 2015
Director Us Site and Insect Control

Education:

University of Florida 1993 - 1995
University of California, Berkeley 1985 - 1992
Doctorates, Doctor of Philosophy, Philosophy, Entomology Gustavus Adolphus College 1980 - 1984
Bachelors, Biology

Skills:

Entomology
Molecular Biology
Rnai
Discovery Process
In Vitro Screens
Transgenics
Nematology
Biological Control
Biodiversity
Agriculture
Microbiology
Agribusiness
Life Sciences
Genetics
Science
Dna
Biotechnology
Laboratory
Pcr
R
Biochemistry
Genomics
R&D
Global R
Program Management
Research
Research and Development
Polymerase Chain Reaction
Laboratory Skills

Interests:

Children
Economic Empowerment
Environment
Science and Technology
Human Rights
Animal Welfare

James Presnail

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Us Patents

Scorpion Toxins
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US Patent:

6593141, Jul 15, 2003
Filed:

Jun 1, 2001
Appl. No.:

09/857401
Inventors:

Rafael Herman - Wilmington DE
James F. Wong - Newark DE
Albert L. Lu - Newark DE
James K. Presnail - Landenberg PA
Jian-Ming Lee - West Caldwell NJ
Assignee:

E. I. du Pont de Nemours and Company - Wilmington DE
International Classification:

C12N 1511
US Classification:

435440, 435 691, 435471, 435476, 435480, 435483, 4352351, 435325, 435419, 4352523, 43525411, 4353201, 536 235
Abstract:

This invention relates to an isolated nucleic acid fragment encoding scorpion toxins that are K-channel modifiers. The invention also relates to the construction of a chimeric gene encoding all or a substantial portion of the K-channel modifier, in sense or antisense orientation, wherein expression of the chimeric gene results in production of altered levels of the K-channel modifier in a transformed host cell.

Nucleic Acids Encoding Plant Defensins And Methods Of Use Thereof
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US Patent:

6855865, Feb 15, 2005
Filed:

Jun 21, 2002
Appl. No.:

10/178449
Inventors:

Omolayo O. Famodu - Newark DE, US
Rafael Herrmann - Wilmington DE, US
Albert L. Lu - Newark DE, US
Billy Fred McCutchen - Clive IA, US
Guo-Hua Miao - Johnston IA, US
James K. Presnail - Avondale PA, US
Zude Weng - Warsaw IN, US
Assignee:

E.I. du Pont de Nemours and Company - Wilmington DE
International Classification:

C12N015/09
C12N015/29
C11N015/82
A01H005/00
A01H005/10
US Classification:

800279, 800278, 800298, 800295, 800320, 800317, 4353201, 435468, 435419, 536 236
Abstract:

This invention relates to isolated nucleic acids encoding plant defensins. The invention also relates to the construction of a chimeric gene encoding all or a portion of the plant defensin, in sense or antisense orientation, wherein expression of the chimeric gene results in production of altered levels of plant defensins in a transformed host cell.

Nucleic Acid Encoding The Fus6 Antimicrobial Polypeptide Of Agrotis Ipsilon And Its Use To Enhance Disease Resistance In A Plant
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US Patent:

6891085, May 10, 2005
Filed:

Apr 18, 2002
Appl. No.:

10/125258
Inventors:

Daniel J. Altier - Waukee IA, US
Rafael Herrmann - Wilmington DE, US
Albert L. Lu - Newark DE, US
Billy F. McCutchen - Clive IA, US
James K. Presnail - Avondale PA, US
Janine L. Weaver - Bear DE, US
James F. H. Wong - Johnston IA, US
Assignee:

Pioneer Hi-Bred International, Inc. - Johnston IA
E.I. du Pont de Nemours and Company - Wilmington DE
International Classification:

A10H005/00
A10H005/10
C12N015/82
C12N015/11
C12N015/63
US Classification:

800301, 800279, 4353201, 4352351, 424 932, 424 9321, 536 235
Abstract:

The methods and compositions of the present invention find use in impacting microbial pathogens and in enhancing disease resistance to pathogens, particularly by plants. The compositions of the invention include nucleic acid molecules encoding Fus6 polypeptides derived from that possess antimicrobial properties, particularly fungicidal properties. Further provided are plant cells plants, and seed thereof, transformed with the nucleic acid molecules of the invention so as to confer disease resistance on the plant.

Fus6 Family Antimicrobial Polypeptides And Their Uses
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US Patent:

7064183, Jun 20, 2006
Filed:

Mar 29, 2005
Appl. No.:

11/092430
Inventors:

Daniel J. Altier - Waukee IA, US
Rafael Herrmann - Wilmington DE, US
Albert L. Lu - Newark DE, US
Billy F. McCutchen - Clive IA, US
James K. Presnail - Avondale PA, US
Janine L. Weaver - Bear DE, US
James F. H. Wong - Johnston IA, US
Assignee:

Pioneer Hi-Bred International, Inc. - Des Moines IA
E. I. du Pont de Nemours and Company - Wilmington DE
International Classification:

C07K 1/00
US Classification:

530350
Abstract:

The methods and compositions of the present invention find use in impacting microbial pathogens and in enhancing disease resistance to pathogens, particularly by plants. The compositions of the invention include polypeptides that possess antimicrobial properties, particularly fungicidal properties, and the encoding nucleic acid molecules. The polypeptides of the invention are isolated from the hemolymph and fat bodies of insect larvae induced by injection of plant pathogenic fungi. Further provided are plant cells, plants, and seed thereof, transformed with the nucleic acid molecules of the invention so as to confer disease resistance on the plant.

Mag1 Antimicrobial Polypeptides And Their Uses
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US Patent:

7064184, Jun 20, 2006
Filed:

Mar 29, 2005
Appl. No.:

11/093225
Inventors:

Daniel J. Altier - Waukee IA, US
Rafael Herrmann - Wilmington DE, US
Albert L. Lu - Newark DE, US
Billy F. McCutchen - Clive IA, US
James K. Presnail - Avondale PA, US
Janine L. Weaver - Bear DE, US
James F.H. Wong - Johnston IA, US
Assignee:

Pioneer Hi-Bred International, Inc. - Des Moines IA
E. I. duPont de Nemours and Company - Wilmington DE
International Classification:

C07K 14/00
C07K 1/00
US Classification:

530350, 530858
Abstract:

The methods and compositions of the present invention find use in impacting microbial pathogens and in enhancing disease resistance to pathogens, particularly by plants. The compositions of the invention include polypeptides that possess antimicrobial properties, particularly fungicidal properties, and the encoding nucleic acid molecules. The polypeptides of the invention are isolated from the hemolymph and fat bodies of insect larvae induced by injection of plant pathogenic fungi. Further provided are plant cells, plants, and seed thereof, transformed with the nucleic acid molecules of the invention so as to confer disease resistance on the plant.

Genes Encoding Proteins With Pesticidal Activity
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US Patent:

7105332, Sep 12, 2006
Filed:

Apr 18, 2005
Appl. No.:

11/108389
Inventors:

André Abad - W. Des Moines IA, US
Ronald D. Flannagan - Grimes IA, US
Rafael Herrmann - Wilmington DE, US
Theodore W. Kahn - Durham NC, US
Albert L. Lu - Newark DE, US
Billy F. McCutchen - Clive IA, US
James K. Presnail - Avondale PA, US
James F. H. Wong - Johnston IA, US
Assignee:

E.I. Du Pont de Nemours and Company - Wilmington DE
International Classification:

C12N 9/50
C12N 15/00
A61K 38/00
US Classification:

435219, 800279, 530350
Abstract:

The invention provides nucleic acids, and variants and fragments thereof, obtained from strains of encoding δ-endotoxins having pesticidal activity against insect pests. The invention further provides mutagenized nucleic acids that have been modified to encode pesticidal polypeptides such as endotoxins having improved pesticidal activity and/or altered pest specificity. Particular embodiments of the invention provide isolated nucleic acids encoding pesticidal proteins that may be optimized as well as pesticidal compositions, expression cassettes, and transformed microorganisms and plants comprising a nucleic acid of the invention. These compositions find use in methods for controlling pests, especially plant pests.

Scorpion Toxins
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US Patent:

7172901, Feb 6, 2007
Filed:

Jul 8, 2003
Appl. No.:

10/614934
Inventors:

Rafael Herrmann - Wilmington DE, US
Jian-Ming Lee - Monroe CT, US
Albert L. Lu - Newark DE, US
James K. Presnail - Landenberg PA, US
James F H Wong - Johnston IA, US
Assignee:

E. I. du Pont de Nemours and Company - Wilmington DE
International Classification:

C12N 15/12
C12N 15/63
C12N 5/10
C12N 1/16
C12N 1/21
US Classification:

435440, 536 235, 4353201, 4352523, 43525411, 435419, 435455, 435468, 435471, 435348, 4352542
Abstract:

This invention relates to an isolated nucleic acid fragment encoding scorpion toxins that are K-channel agonists. The invention also relates to the construction of a chimeric gene encoding all or a portion of the K-channel agonists, in sense or antisense orientation, wherein expression of the chimeric gene results in production of altered levels of the K-channel agonists in a transformed host cell.

Rhizoc3 Antimicrobial Polypeptides And Their Uses
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US Patent:

7202214, Apr 10, 2007
Filed:

Mar 29, 2005
Appl. No.:

11/092429
Inventors:

Daniel J. Altier - Waukee IA, US
Rafael Herrmann - Wilmington DE, US
Albert L. Lu - Newark DE, US
Billy F. McCutchen - Clive IA, US
James K. Presnail - Avondale PA, US
Janine L. Weaver - Bear DE, US
James F. H. Wong - Johnston IA, US
Assignee:

Pioneer Hi-Bred International, Inc. - Johnston IA
E.I. duPont de Nemours & Company - Wilmington DE
International Classification:

A61K 38/17
C07K 14/435
US Classification:

514 12, 530324
Abstract:

The methods and compositions of the present invention find use in impacting microbial pathogens and in enhancing disease resistance to pathogens, particularly by plants. The compositions of the invention include polypeptides that possess antimicrobial properties, particularly fungicidal properties, and the encoding nucleic acid molecules. The polypeptides of the invention are isolated from the hemolymph and fat bodies of insect larvae induced by injection of plant pathogenic fungi. Further provided are plant cells, plants, and seed thereof, transformed with the nucleic acid molecules of the invention so as to confer disease resistance on the plant.