James K O'Connor

US Patent:

6961740, Nov 1, 2005

Filed:

Aug 1, 2002

Appl. No.:

10/209762

Inventors:

James M. O'Connor - Monmouth Junction NJ, US
Aleta Ricciardi - West Windsor NJ, US

Assignee:

Valaran Corporation - Princeton NJ

International Classification:

G06F017/30

US Classification:

707206

Abstract:

This invention is a method and system for improved garbage collection in a distributed computing system. Garbage collection is the process of releasing resources that are no longer being utilized by the objects to which those resources are allocated. Specifically, a garbage collection system and method are described that allow for different types of garbage collection to be used at different times and/or on different objects or resources in the system. In the preferred embodiment, the garbage collection routines are contained in separate mobile code module that can be changed dynamically interchanged to provide different garbage collection algorithms.

US Patent:

7763582, Jul 27, 2010

Filed:

Feb 21, 2007

Appl. No.:

12/280085

Inventors:

Sheldon Suton Lin - Chatham NJ, US
Ankur Gandhi - Metuchen NJ, US
James Patrick O'Connor - Fanwood NJ, US
Loay A. Al-Zube - Zarga, JO
Joseph Benevenia - Montclair NJ, US
J. Russell Parsons - Perth Amboy NJ, US

Assignee:

University of Medicine and Dentistry Of New Jersey - New Brunswick NJ

International Classification:

A61K 38/28

US Classification:

514 3, 514 4

Abstract:

A method of promoting bone healing in a non-diabetic patient in need thereof by locally administering a therapeutically effective amount of insulin to the patient. A drug delivery device, which includes insulin and a pharmaceutically acceptable carrier, wherein the device is adapted for localized administration of insulin to a patient in need thereof is also presented.

US Patent:

20030093496, May 15, 2003

Filed:

Apr 29, 2002

Appl. No.:

10/135082

Inventors:

James O'Connor - Monmouth Junction NJ, US
James Kerr - Plainsboro NJ, US
Michael Ogg - West Windsor NJ, US
Aleta Ricciardi - West Windsor NJ, US

International Classification:

G06F015/16

US Classification:

709/217000, 709/226000

Abstract:

A novel method, system and service for delivering and instantiating resources and services in a distributed system is described. The invention removes dependencies on location, and the need for location-awareness that are present in existing products and practices. Instead of a lookup service pointing to a specific resource base, the invention returns a proxy that uses a resource service to locate and access resources. The present invention provides a highly-available resource base, allows for load balancing resource bases, admits of any other policy-based decisions (such as cost, speed, or quality of service) on where to retrieve a resource from. For service proxy writers, the invention does not require them to commit in advance to an specific code base servers. Using this method, a priori knowledge of specific resource bases is not required, allowing applications to be constructed dynamically and from the most appropriate resources. A similar methodology is also applied to the instantiation of new services, so that the location of a container for a new service need not to be known in advance.

US Patent:

20110105959, May 5, 2011

Filed:

Aug 20, 2010

Appl. No.:

12/860818

Inventors:

James Patrick O'Connor - Newark NJ, US

Assignee:

ACCELALOX, INC. - Menlo Park CA

International Classification:

A61N 7/00
A61K 38/20
A61K 38/19
A61K 38/18
A61K 38/22
A61K 38/29
A61K 31/40
A61K 31/197
A61K 31/454
A61K 31/41
A61K 31/353
A61P 19/08
A61P 19/10

US Classification:

601 2, 424 852, 424 851, 514 89, 514 91, 514 96, 514 118, 514 88, 514 82, 514423, 514563, 514321, 514567, 514381, 514456, 514428

Abstract:

Methods for promoting osteogenesis to accelerate or enhance bone fracture healing, treat bone defects, and enhance bone formation are disclosed. The methods rely on in vivo or ex vivo modulation of an arachidonic acid metabolic or signaling pathway in general, and, in particular, utilize 5-lipoxygenase inhibitors, leukotriene A4 hydrolase inhibitors, and/or leukotriene B4 receptor antagonists. These molecules can be delivered alone or in combination with one or more agents that inhibit bone resorption, regulate calcium resorption from bone, enhance bone accumulation, enhance bone formation, induce bone formation, impair growth of microorganisms, reduce inflammation, and/or reduce pain.

US Patent:

20110124717, May 26, 2011

Filed:

Nov 5, 2010

Appl. No.:

12/940995

Inventors:

James Patrick O'Connor - Newark NJ, US

Assignee:

ACCELALOX, INC. - Menlo Park CA

International Classification:

A61K 31/7088
A61K 31/05
A61K 31/12
A61P 19/00
A61P 19/08
C12N 5/071

US Classification:

514 44 R, 514734, 514688, 435325

Abstract:

Methods for promoting osteogenesis to accelerate or enhance bone fracture healing, treat bone defects, and enhance bone formation are disclosed. The methods modulate an arachidonic acid metabolic or signaling pathway in general, and, in particular, utilize 5-lipoxygenase inhibitors. These molecules can be delivered alone or in combination with one or more agents that inhibit bone resorption, regulate calcium resorption from bone, enhance bone accumulation, enhance bone formation, induce bone formation, impair growth of microorganisms, reduce inflammation, and/or reduce pain.

US Patent:

20130171094, Jul 4, 2013

Filed:

Jan 14, 2011

Appl. No.:

13/522075

Inventors:

Sheldon Suton Lin - Chatham NJ, US
David Naisby Paglia - New Britain CT, US
James Patrick O'Connor - Fanwood NJ, US
Eric Breitbart - South Orange NJ, US
Joseph Benevenia - Montclair NJ, US

Assignee:

UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY - Somerset NJ

International Classification:

A61K 31/555
A61K 45/06

US Classification:

424 852, 514492, 514 76, 514 86, 514 85, 514 82, 514 88, 514 91, 514 89, 514 96, 514 81, 514 118, 514 167, 424 851, 514 92, 424 937, 556 42

Abstract:

This invention provides a method of promoting bone healing by locally administering a vanadium-based insulin mimetic agent to a patient in need thereof. The invention also provides a new use of insulin-mimetic vanadium compounds for manufacture of medicaments for accelerating bone-healing processes. In addition, the invention also encompasses a bone injury treatment kit suitable for localized administration of insulin-mimetic vanadium compounds or compositions thereof to a patient in need of such treatment.

US Patent:

20150320697, Nov 12, 2015

Filed:

Mar 16, 2015

Appl. No.:

14/659340

Inventors:

- Menlo Park CA, US
James Patrick O'Connor - Newark NJ, US

International Classification:

A61K 31/05
A61K 31/713
A61K 45/06
A61K 31/122

Abstract:

Methods for promoting osteogenesis to accelerate or enhance bone fracture healing, treat bone defects, and enhance bone formation are disclosed. The methods modulate an arachidonic acid metabolic or signaling pathway in general, and, in particular, utilize 5-lipoxygenase inhibitors. These molecules can be delivered alone or in combination with one or more agents that inhibit bone resorption, regulate calcium resorption from bone, enhance bone accumulation, enhance bone formation, induce bone formation, impair growth of microorganisms, reduce inflammation, and/or reduce pain.

US Patent:

20150030653, Jan 29, 2015

Filed:

Jul 6, 2012

Appl. No.:

14/130830

Inventors:

Sheldon S. Lin - Chatham NJ, US
David N. Paglia - New Britain CT, US
James P. O'Connor - Fanwood NJ, US
Aaron Wey - East Brunswick NJ, US
Joseph Benevenia - Montclair NJ, US
Virak Tan - Short Hill NJ, US

Assignee:

RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY - New Brunswick NJ

International Classification:

A61K 31/555
A61L 31/08
A61L 31/16
A61K 45/06

US Classification:

424423, 514492, 424 851

Abstract:

A method for repairing an injury of cartilage in a patient by local administration of an organovanadium agent or use of an implantable device for delivery of an organovanadium agent. Implantable devices containing an organovanadium agent and methods of making these implantable devices are also disclosed.