James W O'Connor

US Patent:

8118823, Feb 21, 2012

Filed:

Feb 27, 2009

Appl. No.:

12/395417

Inventors:

Daniel J. Cotter - North Easton MA, US
Saurav V. Gupta - Needham MA, US
James P. O'Connor - Billerica MA, US
Matthew F. Shinopulos - Burlington MA, US

Assignee:

Integra LifeSciences (Ireland) Ltd. - Tullamore

International Classification:

A61B 17/32

US Classification:

606169

Abstract:

An ultrasonic horn for use with an ultrasonic surgical hand piece including a resonator comprises a contacting annulus having a plurality of angled lands. The lands are alternated around the annulus such that adjacent lands have opposite angles. As a result of the adjacent angled lands, a shear stress field is developed in contacted tissue due to the promotion of refracted longitudinal ultrasonic waves propagating in different directions at the interface to the coupled tissue. The shear stress field enhances the fragmentation and removal rate of fibrous, elastic, and tenacious tissue. The horn is hollow permitting suction to be applied to the tissue for controlling tissue contact with the lands.

US Patent:

8142460, Mar 27, 2012

Filed:

Apr 14, 2006

Appl. No.:

11/404981

Inventors:

Daniel J. Cotter - North Easton MA, US
Maria Benson - West Boylston MA, US
Matthew Shinopulos - Burlington MA, US
James P. O'Connor - Billerica MA, US
Amin Kassam - Ottawa CA, US

Assignee:

Integra LifeSciences (Ireland) Ltd. - Dublin

International Classification:

A61B 17/32

US Classification:

606169

Abstract:

Ultrasonic horns configured for use with a surgical ultrasonic handpiece including a resonator are described. The ultrasonic horns include an elongated member having a longitudinal internal channel extending therethrough. Disposed on the distal end of the elongated member is a tip lead configured for cutting and/or abrading hard tissue, for example bone. The tip lead includes an abrasive surface.

US Patent:

8518066, Aug 27, 2013

Filed:

Dec 14, 2011

Appl. No.:

13/325999

Inventors:

Daniel J. Cotter - North Easton MA, US
Saurav V. Gupta - Needham MA, US
James P. O'Connor - Billerica MA, US
Matthew F. Shinopulos - Burlington MA, US

Assignee:

Integra LifeSciences (Ireland) Ltd.

International Classification:

A61B 17/32

US Classification:

606169, 606107

Abstract:

An ultrasonic horn for use with an ultrasonic surgical hand piece including a resonator comprises a contacting annulus having a plurality of angled lands. The lands are alternated around the annulus such that adjacent lands have opposite angles. As a result of the adjacent angled lands, a shear stress field is developed in contacted tissue due to the promotion of refracted longitudinal ultrasonic waves propagating in different directions at the interface to the coupled tissue. The shear stress field enhances the fragmentation and removal rate of fibrous, elastic, and tenacious tissue. The horn is hollow permitting suction to be applied to the tissue for controlling tissue contact with the lands.

US Patent:

56839162, Nov 4, 1997

Filed:

Jun 5, 1995

Appl. No.:

8/465479

Inventors:

Randal A. Goffe - Medway MA
Stephen E. Zale - Marlborough MA
James L. O'Connor - Chelmsford MA
Stephen B. Kessler - Princeton MA

Assignee:

Hemasure Inc. - Marlborough MA

International Classification:

G01N 33549
G01N 33543

US Classification:

436535

Abstract:

A method and apparatus for carrying out affinity purification of a ligate. The method comprising, (a) providing a ligate containing liquid to a first side of at least one porous hollow fiber membrane with a ligand immobilized thereto that binds and separates the ligate from the liquid, (b) withdrawing a first portion of the liquid from the first side of the porous hollow fiber membrane, (c) recirculating the first portion of liquid to the first side of the porous hollow fiber membrane, (d) repeating steps (a) to (c) until a majority of the liquid has flowed through the porous hollow fiber membrane, and (e) providing an elution solution to one side of the porous hollow fiber membrane under a pressure sufficient to cause the elution solution to flow into and through the membrane to effect disassociation of any ligate-ligand bonds wherein any ligate bound to the ligand is eluted with the elution solution.