James Iran Maxwell

US Patent:

7488601, Feb 10, 2009

Filed:

Oct 17, 2003

Appl. No.:

10/688561

Inventors:

David W. Burke - Carmel IN, US
Lance S. Kuhn - Fishers IN, US
James Maxwell - Carmel IN, US

Assignee:

Roche Diagnostic Operations, Inc. - Indianapolis ID
Roche Operations Ltd. - Hamilton

International Classification:

G01N 27/20

US Classification:

436150, 422 8201, 422 8202, 422 8203, 422 8204, 436 43, 436 68, 436 93, 436 94, 436 95, 436149, 436151

Abstract:

A method of measuring an analyte in a biological fluid comprises applying an excitation signal having a DC component and an AC component. The AC and DC responses are measured; a corrected DC response is determined using the AC response; and a concentration of the analyte is determined based upon the corrected DC response. Other methods and devices are disclosed.

US Patent:

7977112, Jul 12, 2011

Filed:

Dec 9, 2008

Appl. No.:

12/330757

Inventors:

David W. Burke - Carmel IN, US
Lance S. Kuhn - Fishers IN, US
James Maxwell - Carmel IN, US

Assignee:

Roche Diagnostics Operations, Inc. - Indianapolis IN
Roche Operations Ltd. - Hamilton

International Classification:

G01N 27/20

US Classification:

436150, 422 8201, 422 8202, 422 8203, 422 8204, 436 43, 436 68, 436 93, 436 94, 436 95, 436149, 436151

Abstract:

A method of measuring an analyte in a biological fluid comprises applying an excitation signal having a DC component and an AC component. The AC and DC responses are measured; a corrected DC response is determined using the AC response; and a concentration of the analyte is determined based upon the corrected DC response. Other methods and devices are disclosed.

US Patent:

8377707, Feb 19, 2013

Filed:

Jul 17, 2009

Appl. No.:

12/505124

Inventors:

David W. Burke - Carmel IN, US
Lance S. Kuhn - Fishers IN, US
James Maxwell - Carmel IN, US

Assignee:

Roche Diagnostics Operations, Inc. - Indianapolis IN

International Classification:

G01N 27/20
G01N 27/26
G01N 27/02

US Classification:

436150, 20419602, 204401, 422 8201, 422 8202, 436 43, 436 46, 436 93, 436 94, 436 95, 436149, 436151, 702 19, 702 22, 702 23

Abstract:

A method of measuring an analyte in a biological fluid comprises applying an excitation signal having a DC component and an AC component. The AC and DC responses are measured; a corrected DC response is determined using the AC response; and a concentration of the analyte is determined based upon the corrected DC response. Other methods and devices are disclosed.

US Patent:

20110241694, Oct 6, 2011

Filed:

Jun 2, 2011

Appl. No.:

13/151537

Inventors:

David W. Burke - Carmel IN, US
Lance S. Kuhn - Fishers IN, US
James Maxwell - Carmel IN, US

International Classification:

G01R 31/02

US Classification:

324537

Abstract:

A method of measuring an analyte in a biological fluid comprises applying an excitation signal having a DC component and an AC component. The AC and DC responses are measured; a corrected DC response is determined using the AC response; and a concentration of the analyte is determined based upon the corrected DC response. Other methods and devices are disclosed.

US Patent:

55261116, Jun 11, 1996

Filed:

Aug 31, 1993

Appl. No.:

8/114897

Inventors:

Rick L. Collins - Cicero IN
Martin T. Gerber - Carmel IN
Zindel H. Heller - Indianapolis IN
James L. Maxwell - Carmel IN
Edna C. Probst - Cedar Rapids IA
Loy M. Vail - Cicero IN
Stefan Weinert - Fortville IN
Morris J. Young - Indianapolis IN

Assignee:

Boehringer Mannheim Corporation - Indianapolis IN

International Classification:

G01N 3349
G06F15900

US Classification:

356 39

Abstract:

A method for calculating a coagulation characteristic of a sample of blood, a blood fraction, or a control comprises generating an output signal indicative of coagulation of the sample, sampling the output signal at a sampling rate for a predetermined time to provide a plurality of sampled signal values, storing the sampled signal values, rectifying the stored sampled signal values to provide a plurality of envelope values, and storing the envelope values. The stored envelope values are examined in reverse time order to determine a slope of the envelope at each of the stored envelope values. All relative maxima in the stored envelope values are identified. A range of stored envelope values corresponding to each relative maximum is determined. The identified relative maxima are compared to locate an absolute maximum in the stored envelope values. The coagulation characteristic is then calculated from the stored envelope values within the predetermined range of envelope values corresponding to the absolute maximum.