James M Hogle

US Patent:

6416762, Jul 9, 2002

Filed:

Dec 11, 1998

Appl. No.:

09/210282

Inventors:

Diane M. Joseph-McCarthy - Belmont MA
Lyle D. Isaacs - Cambridge MA
George M. Whitesides - Newton MA
Martin Karplus - Cambridge MA
James M. Hogle - Newton MA
James Li-wen Cheh - Somerville MA

Assignee:

President and Fellows of Harvard College - Cambridge MA

International Classification:

A61K 39125

US Classification:

4242161, 4242171, 435 5, 435117, 435118, 435119, 436 91, 436 92, 436 98, 544 3, 544 14, 544 22, 548100

Abstract:

The present invention provides structure-based combinatorial libraries of compounds containing the functional group minima of picornaviruses including poliovirus and rhinovirus. The libraries can be used to screen for therapeutical antiviral compounds, e. g. , anti-picornaviral capsid-binding compounds.

US Patent:

6558899, May 6, 2003

Filed:

Dec 11, 1998

Appl. No.:

09/210118

Inventors:

Simon K. Tsang - Cambridge MA 02140
Diane M. Joseph-McCarthy - Belmont MA 02178
James M. Hogle - Newton MA 02165

International Classification:

C12Q 170

US Classification:

435 5, 435 78, 436518

Abstract:

The present invention is broadly directed to methods of screening viral-binding compounds. In particular, the present invention provides cell-free assays to rapidly screen libraries of compounds for viral-capsid binding activity. Such compounds are useful for anti-viral treatments.

US Patent:

6844171, Jan 18, 2005

Filed:

Jul 1, 1999

Appl. No.:

09/347175

Inventors:

James M. Hogle - Newton MA, US
Harmon J. Zuccola - Brookline MA, US
David Filman - Auburndale MA, US
Carl Elkin - Cambridge MA, US

Assignee:

President and Fellows of Harvard College - Cambridge MA

International Classification:

C12P 2102

US Classification:

435 697, 435 5, 435 41, 435 693, 530350

Abstract:

This invention relates to HDAg peptides, including mutants, derivatives fragments and fusion molecules, including fusion proteins, coiled-coil oligomers, nucleic acid molecules, vectors comprising HDAg nucleic acid molecules, cells comprising said molecules, methods of multivalent expression and association of binding moieties of HDAg fusion molecules, and methods of use involving the molecules. The molecules are particularly useful as a framework for multivalent display via formation of C-terminal and/or N-terminal fusion proteins or via chemical coupling to chemically reactive sidechains, e. g. cysteine residues.

US Patent:

7388070, Jun 17, 2008

Filed:

May 12, 2000

Appl. No.:

09/959948

Inventors:

Donald Coen - Medfield MA, US
James Hogle - Newton MA, US
Carl Elkin - Cambridge MA, US
Harmon J. Zuccola - Brookline MA, US
Kristie Grove Bridges - Maynard MA, US
Scott Lokey - Santa Cruz CA, US

Assignee:

President and Fellows of Harvard College - Cambridge MA

International Classification:

C07C 237/24
C07D 237/24
A61K 31/16
A61P 31/00
A61P 35/00

US Classification:

530232, 560116, 560117

Abstract:

A method for the structure-based identification and selection of inhibitors of processivity factor binding to protein is disclosed herein. Characterization of the protein/processivity factor interface is given. Methods for the structure-based inhibition of processivity factor binding to protein are also given. One embodiment includes a class of peptidomimetics that mimic helical portions of proteins. In addition, methods of treatment of various diseases are given, using the inhibitors of the invention.

US Patent:

20020172942, Nov 21, 2002

Filed:

May 21, 2002

Appl. No.:

10/153130

Inventors:

Diane Joseph-McCarthy - Belmont MA, US
Lyle Isaacs - Cambridge MA, US
George Whitesides - Newton MA, US
Martin Karplus - Cambridge MA, US
James Hogle - Newton MA, US
James Cheh - Somerville MA, US

Assignee:

President and Fellows of Harvard College - Cambridge MA

International Classification:

C12Q001/70
C12Q001/68
G01N033/53
G01N033/543
C 07D 4 3/14
C07D473/02

US Classification:

435/005000, 435/006000, 435/007100, 436/518000, 568/058000, 544/265000, 544/296000

Abstract:

The present invention provides structure-based combinatorial libraries of compounds containing the functional group minima of picornaviruses including poliovirus and rhinovirus. The libraries can be used to screen for therapeutical antiviral compounds, e.g., anti-picornaviral capsid-binding compounds.

US Patent:

20040072149, Apr 15, 2004

Filed:

May 5, 2003

Appl. No.:

10/429915

Inventors:

Simon Tsang - Cambridge MA, US
Diane Joseph-McCarthy - Belmont MA, US
James Hogle - Newton MA, US

International Classification:

C12Q001/70
G01N033/53

US Classification:

435/005000, 435/007100

Abstract:

The present invention is broadly directed to methods of screening viral-binding compounds. In particular, the present invention provides cell-free assays to rapidly screen libraries of compounds for viral-capsid binding activity. Such compounds are useful for anti-viral treatments.

US Patent:

20050101619, May 12, 2005

Filed:

Dec 13, 2004

Appl. No.:

11/010753

Inventors:

Simon Tsang - Cambridge MA, US
Diane Joseph-McCarthy - Belmont MA, US
James Hogle - Newton MA, US

Assignee:

President and Fellows of Harvard College - Cambridge MA

International Classification:

A61K031/513
C07D043/02
C07D417/02

US Classification:

514269000, 544296000, 544310000

Abstract:

The present invention is broadly directed to methods of screening viral-binding compounds. In particular, the present invention provides cell-free assays to rapidly screen libraries of compounds for viral-capsid binding activity. Such compounds are useful for anti-viral treatments.

US Patent:

20050170337, Aug 4, 2005

Filed:

Jan 18, 2005

Appl. No.:

11/038652

Inventors:

James Hogle - Newton MA, US
Harmon Zuccola - Brookline MA, US
David Filman - Auburndale MA, US
Carl Elkin - Cambridge MA, US

Assignee:

President and Fellows of Harvard College - Cambridge MA

International Classification:

C12Q001/70
C07H021/04
C07K014/02
C12N015/86

US Classification:

435005000, 435069300, 435456000, 435325000, 435235100, 530350000, 536023720

Abstract:

This invention relates to HDAg peptides, including mutants, derivatives fragments and fusion molecules, including fusion proteins, coiled-coil oligomers, nucleic acid molecules, vectors comprising HDAg nucleic acid molecules, cells comprising said molecules, methods of multivalent expression and association of binding moieties of HDAg fusion molecules, and methods of use involving the molecules. The molecules are particularly useful as a framework for multivalent display via formation of C-terminal and/or N-terminal fusion proteins or via chemical coupling to chemically reactive sidechains, e.g. cysteine residues.