James D Derouin

US Patent:

7127285, Oct 24, 2006

Filed:

Feb 7, 2003

Appl. No.:

10/359559

Inventors:

Julian L. Henley - New Haven CT, US
Kuo Wei Chang - Waltham MA, US
Joseph Potter - Oak Bluffs MA, US
Dennis I. Goldberg - South Brookline MA, US
James Derouin - Taunton MA, US

Assignee:

Transport Pharmaceuticals Inc. - West Conshohoken PA

International Classification:

A61N 1/30

US Classification:

604 20, 604501, 607148

Abstract:

A system for delivering a substance into a body at a treatment site that includes an alternating current source and a plurality of electrodes. Circuitry is connected between the alternating current source and the electrodes for supplying current to the electrodes when the electrodes are in electrical contact with said body so that a uni-directional current flow for delivering the substance into the body is maintained at the treatment site and a bi-directional current flow is maintained throughout the body. At least one of the electrodes is divided into sub-electrodes to, for example, reduce hazards associated with current concentration. These and other systems and methods are adaptable for large treatment areas and/or use a convenient and low-cost arrangement of electronics.

US Patent:

8328788, Dec 11, 2012

Filed:

May 11, 2011

Appl. No.:

13/105630

Inventors:

Julian L. Henley - New Haven CT, US
Kuo Wei Chang - Waltham MA, US
Joseph Potter - Oak Bluffs MA, US
Dennis I. Goldberg - South Brookline MA, US
James Derouin - Taunton MA, US

Assignee:

Nitric Biotherapeutics, Inc. - Bristol PA

International Classification:

A61N 1/30

US Classification:

604501, 604 20

Abstract:

A method for delivering a substance to an infected nail of an individual is described. The method includes the step of applying a device to at least one infected nail of an individual, where the device includes at least one active electrode and at least one counter electrode, where the at least one counter electrode is in contact with the individual, and where the device is connected to at least one power source. The method also includes the steps of disposing a medicament between the at least one active electrode and the at least one infected nail, applying a salt solution to the at least one infected nail, and providing an electrical current from the power source to the at least one active electrode to facilitate delivery of the medicament into the region of the at least one infected nail.

US Patent:

8352024, Jan 8, 2013

Filed:

Mar 13, 2006

Appl. No.:

11/373301

Inventors:

Julian L. Henley - New Haven CT, US
Kuo Wei Chang - Waltham MA, US
Joseph Potter - Oak Bluffs MA, US
Dennis I. Goldberg - South Brookline MA, US
James Derouin - Taunton MA, US

Assignee:

Nitric Biotherapeutics, Inc. - Bristol PA

International Classification:

A61N 1/30

US Classification:

604 20

Abstract:

An electrokinetic delivery system for personal use in self-administration of a medicament to a treatment site on an individual includes a device shaped to conform with the shape of a portion of an individual's finger from a tip thereof to a location past the first finger joint. A self-contained power source is carried by the device and a first electrode is carried by the device adjacent a distal end portion thereof and the tip of the individual's finger. The first electrode is in electrical contact with the power source. A second electrode is carried by the device for contact with the individual's finger. The second electrode is in electrical contact with the power source. Upon application of the first electrode over a treatment site with the medicament disposed between the first electrode and the treatment site and completion of an electrical circuit through the individual's body and said electrode, the device applies current for electrokinetically driving the medicament into the treatment site.

US Patent:

8388892, Mar 5, 2013

Filed:

Nov 12, 2010

Appl. No.:

12/927364

Inventors:

Daniel Harjes - Allston MA, US
John Williams - Lexington MA, US
James A. Bickford - Winchester MA, US
Daniel Traviglia - Allston MA, US
David G. D'Amore - Winthrop MA, US
James D. Derouin - Taunton MA, US

Assignee:

The Charles Stark Draper Laboratory, Inc. - Cambridge MA

International Classification:

G01N 31/12
G01N 21/72
G01N 1/18
G01M 1/38
G05B 13/00
G05B 15/00
G05D 23/00
G01N 31/00

US Classification:

422 78, 436155, 436157, 700274, 702 24

Abstract:

An in-line loss-on-ignition measurement system includes an on-site extractor subsystem configured to collect fuel or a combustion by-product from a hydrocarbon fuel burning plant. An on-site analyzer is configured to receive the collected matter from the extractor subsystem and configured to weigh the collected matter, burn the collected matter, and weight the collected matter again. A controller is responsive to the analyzer and is configured to determine the loss-on-ignition data for the plant based on the weight of the collected matter before and after it is burned in the analyzer.

US Patent:

20020161324, Oct 31, 2002

Filed:

Apr 8, 2002

Appl. No.:

10/117346

Inventors:

Julian Henley - New Haven CT, US
Kuo Chang - Waltham MA, US
Joseph Potter - Oak Bluffs MA, US
Dennis Goldberg - South Brookline MA, US
James Derouin - Taunton MA, US

Assignee:

BioPhoretic Therapeutic Systems, LLC

International Classification:

A61N001/30

US Classification:

604/020000

Abstract:

An electrokinetic delivery system for personal use in self-administration of a medicament to a treatment site on an individual includes a device shaped to conform with the shape of a portion of an individual's finger from a tip thereof to a location past the first finger joint. A self-contained power source is carried by the device and a first electrode is carried by the device adjacent a distal end portion thereof and the tip of the individual's finger. The first electrode is in electrical contact with the power source. A second electrode is carried by the device for contact with the individual's finger. The second electrode is in electrical contact with the power source. Upon application of the first electrode over a treatment site with the medicament disposed between the first electrode and the treatment site and completion of an electrical circuit through the individual's body and said electrode, the device applies current for electrokinetically driving the medicament into the treatment site.

US Patent:

20060025715, Feb 2, 2006

Filed:

Sep 28, 2005

Appl. No.:

11/236748

Inventors:

Julian Henley - New Haven CT, US
Kuo Chang - Waltham MA, US
Joseph Potter - Oak Bluffs MA, US
Dennis Goldberg - South Brookline MA, US
James Derouin - Taunton MA, US

Assignee:

BIOPHORETIC THERAPEUTIC SYSTEMS, LLC - Framingham MA

International Classification:

A61N 1/30

US Classification:

604020000

Abstract:

A system for delivering a substance into a body at a treatment site that includes an alternating current source and a plurality of electrodes. Circuitry is connected between the alternating current source and the electrodes for supplying current to the electrodes when the electrodes are in electrical contact with said body so that a uni-directional current flow for delivering the substance into the body is maintained at the treatment site and a bi-directional current flow is maintained throughout the body. At least one of the electrodes is divided into sub-electrodes to, for example, reduce hazards associated with current concentration. These and other systems and methods are adaptable for large treatment areas and/or use a convenient and low-cost arrangement of electronics.

US Patent:

20100198408, Aug 5, 2010

Filed:

Jan 26, 2010

Appl. No.:

12/657706

Inventors:

Daniel Harjes - Allston MA, US
John Williams - Lexington MA, US
James A. Bickford - Winchester MA, US
Daniel Traviglia - Allston MA, US
David G. D'Amore - Winthrop MA, US
James D. Derouin - Taunton MA, US

International Classification:

F23N 5/26
G06F 19/00

US Classification:

700274, 702 24

Abstract:

An in-line loss-on-ignition measurement system featuring an extractor configured to collect fuel or a combustion by-product from a hydrocarbon fuel burning plant, an on-site analyzer configured to receive the collected matter and determine loss-on-ignition data for the plant, a transfer mechanism configured to transfer the collected matter from the extractor to the analyzer, and a controller for displaying the loss-on-ignition data and/or for automatically adjusting one or more parameters associated with the plant.

US Patent:

20110208111, Aug 25, 2011

Filed:

Apr 29, 2011

Appl. No.:

13/097982

Inventors:

Julian L. Henley - New Haven CT, US
Kuo Wei Chang - Waltham MA, US
Joseph Potter - Oak Bluffs MA, US
Dennis I. Goldberg - South Brookline MA, US
James Derouin - Taunton MA, US

International Classification:

A61N 1/30

US Classification:

604 20

Abstract:

The invention relates to systems and methods for treating a fungal infection of the nail of an individual. In various embodiments, the methods include applying a device to at least one nail of the individual that is infected by a fungus. In various embodiments, the devices include at least one active electrode and at least one counter electrode, with the at least one counter electrode in contact with the individual.