Jacob L Bernstein

US Patent:

8545543, Oct 1, 2013

Filed:

Jul 26, 2010

Appl. No.:

12/843587

Inventors:

Anthony Zorzos - Cambridge MA, US
Clifton Fonstad - Arlington MA, US
Edward Boyden - Chestnut Hill MA, US
Jacob Bernstein - Cambridge MA, US

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

A61N 5/06
A61N 5/067
G02B 6/10

US Classification:

607 89, 607 93, 385129, 385130, 385131

Abstract:

This invention may be implemented as a microstructure probe for delivering light of variable color and/or power, via a set of integrated lightguides, from an optical source (or set of sources) to regions spatially arranged 3-dimensionally, with a length scale of microns to millimeters. In exemplary embodiments of this invention, a microstructure probe comprises many lightguides and is adapted to be inserted into neural or other tissue. The lightguides run in parallel along at least a portion of the axis of the probe. The probe may deliver light to many points along the axis of insertion of the probe. This invention may be implemented as an array of two or more such probes (each of which comprises multiple lightguides). This array may be used to deliver light to neural tissue in a complex 3D pattern.

US Patent:

20080306576, Dec 11, 2008

Filed:

May 9, 2008

Appl. No.:

12/118673

Inventors:

Edward S. Boyden - Cambridge MA, US
Jacob G. Bernstein - Cambridge MA, US

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

A61N 5/06

US Classification:

607 91

Abstract:

A prosthetic device for optical control of target cells comprises a set of light sources, hardware for guiding light to the target cells, supporting hardware that holds members of the set of light sources with respect to each other and the target cells, control circuitry for controlling the set of light sources, and power circuitry that provides power to the set of light sources and the control circuitry. The device may be wearable or implantable, and may be remotely powered or employ wireless communication. The supporting hardware may comprise implantable hypodermics or cannulas, or a plate or scaffold. The set of light sources may be assembled into an array.

US Patent:

20090210039, Aug 20, 2009

Filed:

Jan 16, 2009

Appl. No.:

12/355745

Inventors:

Edward S. Boyden - Cambridge MA, US
Jacob G. Bernstein - Cambridge MA, US
Michael Henninger - Cambridge MA, US

International Classification:

A61N 5/067
A61N 5/06

US Classification:

607 89, 607 88

Abstract:

An optical prosthesis that permits control of neural circuits comprises a probe having a set of light sources, drive circuit connections connected to each light source, a housing surrounding the light sources and drive circuit connections, and drive circuitry for driving and controlling the probe. The drive circuit connections and drive circuitry may optionally provide for wireless communication. The light sources may be light-emitting diodes, lasers, or other suitable sources. The device may optionally include sensors for monitoring the target cells. The present invention is also a multi-dimensional array of probes, each probe having a set of light sources, drive circuit connections connected to each light source, a housing surrounding the light sources and the drive circuit connections, drive circuitry for driving and controlling the probes, and supporting hardware that holds the probes in position with respect to each other and the target cells.

US Patent:

20120089205, Apr 12, 2012

Filed:

Oct 24, 2011

Appl. No.:

13/280229

Inventors:

Edward Boyden - Chestnut Hill MA, US
Jacob Bernstein - Cambridge MA, US
Christian Wentz - Cambridge MA, US
Michael Baratta - Boulder CO, US
Brian Allen - Cambridge MA, US
Anthony Zorzos - Cambridge MA, US
Jorg Scholvin - Boston MA, US
Clifton Fonstad - Arlington MA, US

Assignee:

MASSACHUSETTS INSTITUTE OF TECHNOLOGY - Cambridge MA

International Classification:

A61N 5/06

US Classification:

607 88

Abstract:

In exemplary implementations of this invention, high-throughput screening of a mammalian brain is performed to locate neural circuit targets of interest. A variety of search patterns may be used for this neural screening, including (a) iterative subdivision, (b) serial search, and (c) combinatorial. To perform this neural screening, an array of optical fibers (or an array of waveguides) is inserted into the brain. Alternately, the array is positioned adjacent to the brain. Each fiber or waveguide in the array is coupled to a light source (LED or laser). The brain has been previously sensitized to light, using genetically encoded optical neural control reagents, which are delivered either using viruses or via transgenic means. In the screening, the array is used to optically perturb the brain. For example, the neurons of the brain may be activated by one color of light, and/or silenced by another color of light.

US Patent:

20140324138, Oct 30, 2014

Filed:

Jun 13, 2014

Appl. No.:

14/304259

Inventors:

Christian Wentz - Cambridge MA, US
Jacob Bernstein - Cambridge MA, US
Edward Boyden - Chestnut Hill MA, US

Assignee:

MASSACHUSETTS INSTITUTE OF TECHNOLOGY - Cambridge MA

International Classification:

A61N 5/06

US Classification:

607 92, 607 88, 607 90

Abstract:

In exemplary implementations of this invention, an implant device is wholly or partially implanted in a mammal. The implant device includes an antenna, circuitry, a supercapacitor, one or more light sources, and an array of optical fibers or light guides. The antenna and circuitry receive energy by wireless transmission from an external transmit coil. The supercapacitor stores at least a portion of the energy and provides power to one or more light sources. The array of optical fibers or light guides deliver light from the light sources to living tissue of a mammal. The tissue includes light-sensitive, heterologously expressed proteins. The light affects the light-sensitive proteins, triggering a change in all or part of the tissue, such as a change in voltage, pH or a change in function.

Author:

Jacob I. Bernstein

ISBN #:

0471502146

Author:

Jacob I. Bernstein

ISBN #:

0471512516

Author:

Jacob Bernstein

ISBN #:

0071361251

Author:

Jacob Bernstein

ISBN #:

0071376771

Author:

Jacob Bernstein

ISBN #:

0071381945

Author:

Jacob Bernstein

ISBN #:

0470109874

Author:

Jacob Bernstein

ISBN #:

0471011851

Author:

Jacob Bernstein

ISBN #:

0471081973