Ilias K Dorziotis

US Patent:

6479672, Nov 12, 2002

Filed:

Apr 7, 2000

Appl. No.:

09/545313

Inventors:

Ioannis Houpis - Plainfield NJ
Ralph P. Volante - Cranbury NJ
Fengrui Lang - Piscataway NJ
Ilias Dorziotis - Bridgewater NJ
David Tschaen - Holmdel NJ
Shinji Kato - Nagoya NJ
Toshiaki Mase - Okazaki NJ

Assignee:

Merck Co., Inc. - Rahway NJ
Banyu Pharmaceutical Co., Ltd, - Tokyo

International Classification:

C07D31734

US Classification:

549267

Abstract:

Michael addition conducted in the presence of a zinc-amine complex and additional amounts of the amine component results in product with high diastereomeric excess.

US Patent:

60463333, Apr 4, 2000

Filed:

Oct 21, 1997

Appl. No.:

8/955124

Inventors:

Ilias Dorziotis - Bridgewater NJ
Ioannis Houpis - Plainfield NJ
Audrey Molina - Clark NJ
Ralph Volante - Cranbury NJ

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

C07D40100

US Classification:

546 18

Abstract:

The present invention is directed to a novel convergent process for the preparation of the compound N-[1(R)-[(1,2-dihydro-1-methanesulfonyl-spiro[3H-indole-3,4'-piperdin]-1'- yl)carbonyl]-2-(phenylmethyl-oxy)ethyl]-2-amino-2-methyl-propanamide, and salts thereof, which has the structure: ##STR1## and which has the ability to stimulate the release of natural or endogenous growth hormone. This compound may be used to treat conditions which require the stimulation of growth hormone production or secretion such as in humans with a deficiency of natural growth hormone or in animals used for food or wool production where the stimulation of growth hormone will result in a larger, more productive animal.

US Patent:

60808764, Jun 27, 2000

Filed:

Sep 17, 1998

Appl. No.:

9/160203

Inventors:

Ilias Dorziotis - Bridgewater NJ
Ioannis Houpis - Plainfield NJ
Kan K. Eng - Yonkers NY

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

C07D30758
C07D30760

US Classification:

549319

Abstract:

The invention encompasses a process for making compounds of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. ##STR1##.

US Patent:

58564985, Jan 5, 1999

Filed:

Sep 16, 1997

Appl. No.:

8/931155

Inventors:

Ilias K. Dorziotis - Bridgewater NJ
Ioannis N. Houpis - Plainfield NJ
Jaemoon Lee - Edison NJ
Ralph P. Volante - Cranbury NJ

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

C07D21330
C07D213127

US Classification:

546339

Abstract:

This invention is concerned with a novel process for the preparation of a compound of structural formula I ##STR1## wherein R. sup. 1 and R. sup. 2 independently are aryl, C. sub. 2-15 alkenyl or C. sub. 1-15 alkyl, either unsubstituted or substituted with one or three substituents, which can be the same or different, selected from the group consisting of R. sup. a, wherein R. sup. a belongs to a group consisting of C. sub. 1-6 alkyl, aryl, halo, --N(R. sup. 3). sub. 2, --NO. sub. 2, --CN, --OR. sup. 3, --C. sub. 3-6 cycloalkoxy, --CO(R. sup. 3), --COOR. sup. 3, SO. sub. 2 R. sup. 3 and --SR. sup. 3 ; wherein R3 is selected from the group consisting of hydrogen, C. sub. 1-6 alkyl, C. sub. 2-6 alkenyl and aryl, said alkyl, alkenyl or aryl optionally substituted with 1 to 3 groups of R. sup. a, which is an important antiasthmatic agent.