Ilene P Sussman

US Patent:

58372407, Nov 17, 1998

Filed:

Aug 26, 1997

Appl. No.:

8/920095

Inventors:

Cynthia K. Lee - Needham MA
Thomas P. Monath - Harvard MA
Samuel K. Ackerman - Weston MA
William D. Thomas - Winchester MA
Gopalan Soman - Belmont MA
Harold Kleanthous - Allston MA
Richard A. Weltzin - Lunenburg MA
Jacques Pappo - Newton MA
Thomas Ermak - Brookline MA
Farshad Guirakhoo - Melrose MA
Hitesh Bhagat - Framingham MA
Ilene Sussman - Newton MA

Assignee:

OraVax-Merieux Co. - Cambridge MA

International Classification:

A61K 3846
A61K 3902
A61K 39106

US Classification:

424 946

Abstract:

Methods and compositions are provided for prophylactic and antibacterial therapy for Helicobacter, particularly for Helicobacter pylori, infection of humans. The immunogenic composition of the invention is composed of a plurality of multimeric complexes, each complex being composed of recombinant, enzymatically inactive Helicobacter pylori urease. Each multimeric complex is composed of six Urease A subunits and six Urease B subunits. Alternatively, the composition is composed of a mixture of multimeric complexes, wherein each multimeric complex in the mixture is composed of six Urease A subunits and six Urease B subunits or four Urease A subunits and four Urease B subunits.