Ian R Wheeldon

US Patent:

20090075335, Mar 19, 2009

Filed:

Oct 10, 2008

Appl. No.:

12/249427

Inventors:

Scott Banta - New York NY, US
Scott Andrew Calabrese Barton - East Lansing MI, US
Ian R. Wheeldon - New York NY, US

Assignee:

The Trustees Of Columbia University In The City Of New York - New York NY

International Classification:

C12P 21/02
A61K 38/02
C07K 19/00
C12N 9/00

US Classification:

435 691, 514 2, 530350, 435183

Abstract:

Protein hydrogel monomers incorporating bio-active proteins and methods for producing the same are provided. In some embodiments, the disclosed subject matter includes a protein hydrogel monomer including a bio-active protein and two alpha helices that are adapted to interact with alpha helices on other monomers to form coiled-coil junctions.

US Patent:

20190017041, Jan 17, 2019

Filed:

Jul 23, 2018

Appl. No.:

16/042313

Inventors:

- New York NY, US
Mark A. BLENNER - Clemson SC, US
Ian WHEELDON - Riverside CA, US
Kevin DOOLEY - New York NY, US

Assignee:

THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK - New York NY

International Classification:

C12N 9/88
A61L 15/44
A61L 27/22
A61L 15/60
A61L 15/46
A61L 15/42
A61L 15/32
A61L 27/54
A61L 27/52
A61L 27/50
C08L 89/00

Abstract:

In one aspect, the invention relates to a peptide that forms a calcium-dependent hydrogel using a rationally engineered beta roll peptide. In the absence of calcium, the peptide is intrinsically disordered. Upon addition of calcium, the peptide forms a corkscrew-like structure. In one embodiment, one face of the beta roll is mutated to comprise leucine residues. In some embodiments, a leucine zipper forming helical domain to the engineered beta roll forms hydrogels by physical cross-linking in calcium rich environments.

US Patent:

20160152966, Jun 2, 2016

Filed:

Jul 30, 2015

Appl. No.:

14/814102

Inventors:

- New York NY, US
Mark A. BLENNER - Clemson SC, US
Ian WHEELDON - Riverside CA, US
Kevin DOOLEY - New York NY, US

Assignee:

THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK - New York NY

International Classification:

C12N 9/88

Abstract:

In one aspect, the invention relates to a peptide that forms a calcium-dependent hydrogel using a rationally engineered beta roll peptide. In the absence of calcium, the peptide is intrinsically disordered. Upon addition of calcium, the peptide forms a corkscrew-like structure. In one embodiment, one face of the beta roll is mutated to comprise leucine residues. In some embodiments, a leucine zipper forming helical domain to the engineered beta roll forms hydrogels by physical cross-linking in calcium rich environments.

US Patent:

20140123578, May 8, 2014

Filed:

Mar 1, 2012

Appl. No.:

14/000999

Inventors:

Donald E. Ingber - Boston MA, US
Benjamin D. Hatton - Toronto, CA
Ian R. Wheeldon - Arlington MA, US
Joanna Aizenberg - Boston MA, US

Assignee:

PRESIDENT AND FELLOWS OF HARVARD COLLEGE - Cambridge MA

International Classification:

E06B 3/67
E06B 3/663

US Classification:

521713, 52209, 521731

Abstract:

A bio-inspired window can be created by applying one or more heat exchange layers to one or more surfaces of a window of a building, boat, vehicle or any other structure. The heat exchange layer can include an interconnected network or array of channels or microchannels that can be used to flow a fluid over the surface of the window. The fluid can be used to heat or cool the surface of the window panel to control the flow of heat across the window and reduce the heating or cooling energy load of building. The fluid can be heated or cooled using the ambient air in the building. The refractive index of the fluid can be adjusted to change of optical transparency properties of the window. In some embodiments, the window can appear nearly as clear as an ordinary panel of glass. In other embodiments, the window can color, block or scatter the incoming light.