Hudson H Freeze from 2111 Garfield Rd, San Diego, CA 92110, age 78, Phone: 619 276-8619

Diagnosis Of Human Glycosylation Disorders
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US Patent:

7674577, Mar 9, 2010
Filed:

May 5, 2006
Appl. No.:

11/381941
Inventors:

Jamey D. Marth - San Diego CA, US
Hudson H. Freeze - San Diego CA, US
Assignee:

The Regents of the University of California - Oakland CA
The Burnham Institute - La Jolla CA
International Classification:

G01N 33/53
G01N 33/566
G01N 33/68
US Classification:

435 4, 435 721, 436501, 436 63, 436 87, 436 94, 436827
Abstract:

This invention provides methods and kits for use in diagnosing genetically transmitted diseases that are associated with deficiencies in glycosylation of glycoconjugates such as glycoproteins, glycolipids, and proteoglycans. The methods and kits are also useful for monitoring the course of treatment of diseases that are associated with glycosylation disorders.

Novel Ligand Involved In The Transmigration Of Leukocytes Across The Endothelium And Uses Therefor
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US Patent:

20050118688, Jun 2, 2005
Filed:

Dec 27, 2002
Appl. No.:

10/500480
Inventors:

Hudson Freeze - San Diego CA, US
Geetha Srikrishna - La Jolla CA, US
Ajit Varki - Del Mar CA, US
International Classification:

C12P019/04
C07H001/00
US Classification:

435101000, 536123120
Abstract:

The present invention provides methods and compositions involved in the inflammatory response, as well as various pathological processes. In particular, the present invention provides novel antibodies directed against novel glycans that are enriched on endothelial cell surfaces. In addition, the present invention provides methods and compositions involved in a previously unrecognized pathway of the inflammatory response and various pathological processes. In addition the present invention provides methods and compositions suitable to mediate the inflammatory response in various settings, as well as methods and compositions for the identification of other inflammatory response mediators.

Methods For Diagnosing And Treating Cancer
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US Patent:

20100021472, Jan 28, 2010
Filed:

Jul 27, 2009
Appl. No.:

12/510053
Inventors:

Geetha Srikrishna - San Diego CA, US
Hudson H. Freeze - San Diego CA, US
Pratima Sinha - Baltimore MD, US
International Classification:

A61K 39/395
US Classification:

4241431, 4241721
Abstract:

Aspects of the present invention relate to molecular biology and medicine. More specifically, some embodiments include methods for treating and/or diagnosing inflammation and/or cancer using agents that inhibit the binding of a pro-inflammatory protein or protein complex (e.g., S100A8 and/or S100A9) to a carboxylated glycan expressed on a myeloid (e.g., MDSC), monocytic, dendritic, endothelial, or tumor cell.

Novel Ligand Involved In The Transmigration Of Leukocytes Across The Endothelium And Uses Therefor
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US Patent:

20100249383, Sep 30, 2010
Filed:

Jul 13, 2009
Appl. No.:

12/501926
Inventors:

Hudson Freeze - San Diego CA, US
Geetha Srikrishna - La Jolla CA, US
Ajit Varki - Del Mar CA, US
Nissi Varki - Del Mar CA, US
International Classification:

C07K 16/00
C12N 5/12
US Classification:

5303881, 435326
Abstract:

The present invention provides methods and compositions involved in the inflammatory response, as well as various pathological processes. In particular, the present invention provides novel antibodies directed against novel glycans that are enriched on endothelial cell surfaces. In addition, the present invention provides methods and compositions involved in a previously unrecognized pathway of the inflammatory response and various pathological processes. In addition the present invention provides methods and compositions suitable to mediate the inflammatory response in various settings, as well as methods and compositions for the identification of other inflammatory response mediators.

Benzoisothiazolones As Inhibitors Of Phosphomannose Isomerase
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US Patent:

20110257233, Oct 20, 2011
Filed:

Mar 18, 2011
Appl. No.:

13/051910
Inventors:

Nicholas D. P. Cosford - San Diego CA, US
Hudson H. Freeze - San Diego CA, US
Russell Dahl - Carlsbad CA, US
Yalda Bravo - San Diego CA, US
Vandana Sharma - San Diego CA, US
Mie Ichikawa - San Diego CA, US
Assignee:

Sanford-Burnham Medical Research Institute - La Jolla CA
International Classification:

A61K 31/428
A61P 31/04
A61P 31/00
A61P 3/10
A61P 25/00
A61P 1/16
A61P 13/12
C07D 275/04
A61P 27/10
US Classification:

514373, 548209
Abstract:

The disclosure provides new compounds and compositions thereof, and methods for treating or ameliorating a disorder relating to CDG-Ia. In particular, the disclosure provides benzoisothiazolone inhibitors of PMI, which have been synthesized and their ability to drive glycosylation has been demonstrated. The disclosure provides two synthetic routes for these compounds, including a new copper-catalyzed N-arylation reaction amenable to parallel derivitization. The disclosed compounds represent potent inhibitors of PMI, and their dose-dependent efficacy in cell-based models of glycosylation have been demonstrated. In addition, the disclosed compounds are selective over PMM and therefore, are useful in treating or ameliorating a disorder relating to CDG-Ia.

Diagnosis Of Human Glycosylation Disorders
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US Patent:

7273711, Sep 25, 2007
Filed:

Dec 1, 1999
Appl. No.:

09/857233
Inventors:

Jamey D. Marth - San Diego CA, US
Hudson H. Freeze - San Diego CA, US
Assignee:

The Regents of the University of California - Oakland CA
The Burnham Institute - La Jolla CA
International Classification:

G01N 33/50
G01N 33/53
G01N 33/68
US Classification:

435 724, 435 4, 435 721, 436 63, 436 87, 436 94, 436827
Abstract:

This invention provides methods and kits for use in diagnosing genetically transmitted diseases that are associated with deficiencies in glycosylation of glycoconjugates such as glycoproteins, glycolipids, and proteoglycans. The methods and kits are also useful for monitoring the course of treatment of diseases that are associated with glycosylation disorders.