Huanbiao M Mo

US Patent:

6566397, May 20, 2003

Filed:

Jul 16, 2001

Appl. No.:

09/906521

Inventors:

Charles E. Elson - Madison WI
Manfred Jung - Munster, DE
Huanbiao Mo - Denton TX

Assignee:

Wisconsin Alumni Research Foundation - Madison WI

International Classification:

A61K 3335

US Classification:

514532, 514544, 514529, 514546, 514722, 514670, 514717, 514718, 549398, 549401, 549404

Abstract:

A method of and compositions for suppressing the growth of tumor cells in a patient are disclosed. In one embodiment, the method comprises treating the patient with an effective amount of an isoprenoid ether-linked compound, wherein the isoprenoid ether-linked compound comprises a first acyclic isoprenoid molecule linked via an ether linkage to a second molecule, wherein the second molecule can suppress tumor formation.

US Patent:

7074825, Jul 11, 2006

Filed:

Mar 7, 2003

Appl. No.:

10/383811

Inventors:

Huanbiao Mo - Denton TX, US
Charles E. Elson - Madison WI, US
Dennis M. Peffley - Lee's Summit MO, US
Patricia M. Hentosh - Lee's Summit MO, US

International Classification:

A61K 31/35
A61K 31/335

US Classification:

514456, 514458, 514460

Abstract:

A composition and an associated method of treating cancer cells by impeding cancer cell growth with the composition are disclosed. The composition includes at least a first and a second HMG-CoA reductase inhibitor, wherein the total amount of the first and second HMG-CoA reductase inhibitors is effective in synergistically impeding cancer cell growth and wherein the cancer cell growth synergistic impedance from the total amount of the first and second HMG-CoA reductase inhibitors is greater than a theoretical additive effect from the combined first and second HMG-CoA reductase inhibitors. The present composition does not simultaneously contain both a tocotrienol and an ionone when the composition contains only a first and a second HMG-CoA reductase inhibitor. The method includes treating cancer cells with the claimed composition to impede cancer cell growth.

US Patent:

63036541, Oct 16, 2001

Filed:

Mar 5, 1999

Appl. No.:

9/263622

Inventors:

Charles E. Elson - Madison WI
Huanbiao Mo - Madison WI

Assignee:

Wisconsin Alumni Research Foundation - Madison WI

International Classification:

A01N 3712
A01N 3710

US Classification:

514535

Abstract:

A method of inhibiting or preventing the growth of tumor cells is disclosed. In one embodiment, this method comprises the step of administering a compound selected from the group consisting of citracetal, citral dimethyl acetal, citral diethyl acetal, geranyl benzoate, geranyl tiglate, geranyl anthranilate, farnesyl benzoate, farnesyl anthranilate, farnesyl tiglate, farnesyl acetate and combinations thereof to a human tumor patient, wherein the amount is effective to reduce or inhibit tumor growth by at least 50%.