Howard S An

US Patent:

6866682, Mar 15, 2005

Filed:

Sep 2, 1999

Appl. No.:

09/388726

Inventors:

Howard An - Riverwoods IL, US
Yves Crozet - Ramsey NJ, US
Todd Harrington - Hoboken NJ, US

Assignee:

Stryker Spine

International Classification:

A61F002/44

US Classification:

623 1715, 623 1711

Abstract:

A corpectomy device has an inner member telescopingly disposed in an outer member so that the inner member is movable in an axial direction. The inner and outer members are hollow, defining a chamber, and include apertures in communication with the chamber. A locking clip engages the inner and outer members to fix the position of the inner member with respect to the outer member. The longitudinal dimension of the device is adjustable by distracting the inner member so that the inner member extends from the outer member and moving the locking clip from an unlocked position to a locked position.

US Patent:

6905500, Jun 14, 2005

Filed:

Feb 4, 2002

Appl. No.:

10/296609

Inventors:

Chang-Hun Jeon - Seoul, KR
Howard S. An - Chicago IL, US
Ja-Kyo Koo - Seoul, KR

Assignee:

U & I Corporation - Kyunggi-do

International Classification:

A61B017/56

US Classification:

606 61, 606 73

Abstract:

Disclosed is a bone fixation apparatus. This device comprises a bone screw having a head; a cap member placed on an upper part of the head of the bone screw; a receiver member having a bore in which the cap member and the head of the bone screw are respectively accommodated and held, and a U-shaped channel through which a support bar extends; and a compression member threadedly coupled into the receiver member to downwardly bias the support bar. A multitude of stepped portions are formed at a lower end and inner surface of the receiver member to be brought into linear contact with an outer surface of a lower part of the head so that the supporting force for the head of the bone screw is increased.

US Patent:

7648529, Jan 19, 2010

Filed:

Dec 13, 2004

Appl. No.:

11/010496

Inventors:

Howard An - Riverwoods IL, US
Yves Crozet - Bellach, CH
Todd Harrington - Golden CO, US

Assignee:

Stryker Spine

International Classification:

A61F 2/44

US Classification:

623 1715, 606105

Abstract:

A corpectomy device has an inner member telescopingly disposed in an outer member so that the inner member is movable in an axial direction. The inner and outer members are hollow, defining a chamber, and include apertures in communication with the chamber. A locking clip engages the inner and outer members to fix the position of the inner member with respect to the outer member. The longitudinal dimension of the device is adjustable by distracting the inner member so that the inner member extends from the outer member and moving the locking clip from an unlocked position to a locked position.

US Patent:

20110106168, May 5, 2011

Filed:

Nov 2, 2010

Appl. No.:

12/917666

Inventors:

Kara A. Bucci - Chicago IL, US
Daniel Predick - Chicago IL, US
Howard S. An - Glenview IL, US

International Classification:

A61B 17/70
A61B 17/86

US Classification:

606264, 606305

Abstract:

A laminoplasty rod and rod system that allows for variable angulation, translation (distraction and/or compression) and rotation of a spinal lamina bone portion associated with a laminoplasty, prior to fixation thereof. The laminoplasty rod is configured for use with a polyaxial spinal rod bone screw assembly that is adapted to be anchored to the vertebra associated with the laminoplasty, and is attachable to the spinal lamina bone portion. The laminoplasty rod system provides positional attachment of the laminoplasty rod to the spinal components associated with the laminoplasty and fixation thereof in various orientations. The laminoplasty rod system is characterized by a configured laminoplasty rod that fits into or onto the head of a polyaxial spinal rod bone screw assembly. A bone screw boss, defining a bone screw attachment configuration, is formed at one end of the laminoplasty rod. Preferably, but not necessarily, the bone screw boss is situated at an angled end of the rod having a pre-defined bend that provides for greater variation in rod orientation.

US Patent:

20130297023, Nov 7, 2013

Filed:

Mar 15, 2013

Appl. No.:

13/833777

Inventors:

Hee-Jeong Im Sampen - Lincolnwood IL, US
Howard S. An - Glenview IL, US
Di Chen - Chicago IL, US

International Classification:

A61F 2/44

US Classification:

623 1711

Abstract:

Provided are methods for treating intervertebral disc degeneration, promoting tissue regeneration in the intervertebral disc, promoting homeostasis of the intervertebral disc, preventing intervertebral disc degeneration, and reducing inflammation of the intervertebral disc in a subject in need thereof comprising administering a myeloid differentiation primary response (88) (MyD88) antagonist to the subject. Also provided is a device, biomaterial or putty for implantation in or near the spine, wherein the device, biomaterial or putty is coated or infused with a myeloid differentiation primary response gene (88) (MyD88) antagonist.

US Patent:

6280443, Aug 28, 2001

Filed:

Nov 18, 1999

Appl. No.:

9/442766

Inventors:

Ja-Kyo Gu - Seoul, KR
Howard S. An - Chicago IL
Tae-Hong Lim - Naperville IL

International Classification:

A61B 1756

US Classification:

606 61

Abstract:

A spinal fixation system for use in the immobilization of a sequence of spinal bones, comprising a plurality of pedicle screws, a pair of rods, and connectors. The pedicle screw has a spherical head having a round portion at an upper portion of the spherical head, a threaded shaft for insertion through the pedicles, and a threaded stem on the top of the spherical head. The connector has a rod passage for receiving the rod therethrough, a set member bore formed in an upper portion of the connector, and a support portion having an opening formed for adapting the stem of the pedicle screw and a recessed hemispherical wall. A spherical joint at the pedicle screw and the connector allows the multi-directional adjustment capability of the connector so that the screws can be implanted in any angulation with no need of having the screws well aligned. The spherical head of the pedicle screw and the hemispherical wall have slightly different diameters which improve the locking power and provide a rigid fixation. A rigid coupling is achieved between the rod and the connector by making the cross-section of the rod passage as an imperfect circular shape which allows the three point contact between the rod and the rod passage.

US Patent:

20180236005, Aug 23, 2018

Filed:

Apr 19, 2018

Appl. No.:

15/957741

Inventors:

- Houston TX, US
Howard An - Glenview IL, US

International Classification:

A61K 35/33
A61K 45/06
A61K 45/00

Abstract:

The present invention concerns methods and compositions for differentiating cells, including human fibroblasts, into chondrocyte-like cells via in vivo mechanical strain. In particular aspects, fibroblasts are delivered to a joint, such as an intervertebral disc, following which the fibroblasts differentiate into chondrocyte-like cells to treat dysfunction of cartilage therein, including to repair degenerated discs, for example. The fibroblasts that do not differentiate to chondrocytic cells because of the location of the cells, as in the fissures of annulus, or other biomechanical and biochemical micro-environment factors, may produce fibrous matrix molecule(s) in aiding tissue repair and regeneration in both nucleus pulposus and annulus fibrosus. In certain aspects, the fibroblasts prior to delivery to the individual are managed in the absence of growth factors, in vitro mechanical strain, and/or matrix molecules, for example.

US Patent:

20140314726, Oct 23, 2014

Filed:

Nov 8, 2012

Appl. No.:

14/357558

Inventors:

- Houston TX, US
Howard An - Glenview IL, US

International Classification:

A61K 35/12

US Classification:

424 937

Abstract:

The present invention concerns methods and compositions for differentiating cells, including human fibroblasts, into chondrocyte-like cells via in vivo mechanical strain. In particular aspects, fibroblasts are delivered to a joint, such as an intervertebral disc, following which the fibroblasts differentiate into chondrocyte-like cells to treat dysfunction of cartilage therein, including to repair degenerated discs, for example. The fibroblasts that do not differentiate to chondrocytic cells because of the location of the cells, as in the fissures of annulus, or other biomechanical and biochemical micro-environment factors, may produce fibrous matrix molecule(s) in aiding tissue repair and regeneration in both nucleus pulposus and annulus fibrosus. In certain aspects, the fibroblasts prior to delivery to the individual are managed in the absence of growth factors, in vitro mechanical strain, and/or matrix molecules, for example.

Author:

Howard S. An

ISBN #:

0683001272

Author:

Howard S. An

ISBN #:

0683001280

Author:

Howard S. An

ISBN #:

0683180975

Author:

Howard S. An

ISBN #:

0683181084

Author:

Howard S. An

ISBN #:

0683302590

Author:

Howard S. An

ISBN #:

0683302604

Author:

Howard S. An

ISBN #:

0721635229

Author:

Howard S. An

ISBN #:

0812101278