Horace H Loh

US Patent:

7214534, May 8, 2007

Filed:

Jun 18, 2003

Appl. No.:

10/465172

Inventors:

Horace H. Loh - Little Canada MN, US
Wanling Yang - Charleston SC, US
Xiao-Hong Guo - St. Paul MN, US
Patricia A. Geppert - San Antonio TX, US

Assignee:

Regents of the University of Minnesota - Minneapolis MN

International Classification:

C12N 5/10
C12N 15/12
C12N 15/63
C12N 1/21
C12Q 1/68

US Classification:

435325, 435 6, 435 71, 435 691, 4352523, 4353201, 530350, 536 235

Abstract:

The invention provides genetic approaches to inhibit or treat pain which employ mutant μ opioid receptors.

US Patent:

43615538, Nov 30, 1982

Filed:

May 18, 1981

Appl. No.:

6/264830

Inventors:

Horace H. Loh - San Francisco CA
Nancy M. Lee - San Francisco CA

Assignee:

Regents of the University of California - Berkeley CA

International Classification:

A61K 3700

US Classification:

424177

Abstract:

A therapeutic method of using dynorphin comprises administering dynorphin to a host tolerant to narcotic analgesics. Practice of the therapeutic method provides that lower doses of a narcotic analgesic may be used, such as for patients requiring chronic treatment with narcotics to ease pain, and for treatment of narcotics addicts.

US Patent:

44629419, Jul 31, 1984

Filed:

Jun 10, 1982

Appl. No.:

6/387005

Inventors:

Nancy M. Lee - San Francisco CA
Horace H. Loh - San Francisco CA

Assignee:

The Regents of the University of California - Berkeley CA

International Classification:

C07C10352
A61K 3700

US Classification:

2601125R

Abstract:

Dynorphin(1-13) has been previously reported to antagonize the analgesia induced by narcotics in naive hosts. Novel compounds are provided which differ from dynorphin(1-13) by neither potentiating nor antagonizing narcotics, such as morphine, in naive animals. In tolerant hosts the new compounds potentiate narcotic or peptide induced analgesia, and in addition are less susceptible to degradation than dynorphin(1-13). Particularly preferred of the new compounds are polypeptides having ten amino acids with nitrogen containing moieties at both termini.

US Patent:

58078274, Sep 15, 1998

Filed:

May 14, 1997

Appl. No.:

8/856053

Inventors:

Nancy M. Lee - San Francisco CA
Horace H. Loh - San Francisco CA
Akira E. Takemori - Edina MN

Assignee:

Des-Tyr Dynorphin Partnership - San Francisco CA

International Classification:

A61K 3800
A61K 3802
C07K 500
C07K 700

US Classification:

514 14

Abstract:

Novel peptides of the invention are dynorphin analogues and have similar activity to endogenous dynorphin, but are des-Tyr or des-Tyr-Gly with respect to endogenous dynorphin and have at least seven amino acid residues. The novel peptides have therapeutic uses, such as administration to a host tolerant to a narcotic analgesic in order to potentiate activity of the narcotic analgesic and/or to block withdrawal symptoms.

US Patent:

46846247, Aug 4, 1987

Filed:

May 20, 1985

Appl. No.:

6/735948

Inventors:

Yoshio Hosobuchi - San Rafael CA
Nancy M. Lee - San Francisco CA
Horace H. Loh - San Francisco CA

International Classification:

A61K 3702

US Classification:

514 15

Abstract:

A method of treatment for patients suffering from cerebral ischemia is provided by administering an opioid peptide. Particulary preferred is the administration of dynorphin, or dynorphin-related peptides, in the acid or amidated form. Practice of the invention is useful in prolonging survival.

US Patent:

20170056377, Mar 2, 2017

Filed:

Jul 12, 2016

Appl. No.:

15/207951

Inventors:

- Zhunan Town, TW
- Minneapolis MN, US
Horace Loh - Little Canada MN, US
Yu-Sheng Chao - New York NY, US

International Classification:

A61K 31/426
A61K 31/454
A61K 31/5377
G01N 33/50
A61K 31/422
A61K 31/428
A61K 31/485
A61K 31/427
A61K 31/4439

Abstract:

Disclosed is an in vitro screening method for identifying an antagonist-to-agonist allosteric modifier of a mu-opioid receptor and an in vivo method for confirming that a test compound is such a modifier of a mu-opioid receptor. Also disclosed is a method for treating an opioid receptor-associated condition using a compound of Formula (I) and a pharmaceutical composition containing the same.

Author:

Horace H. Loh

ISBN #:

0824304314

Author:

Horace H. Loh

ISBN #:

0824304322

Author:

Horace H. Loh

ISBN #:

0824304349

Author:

Horace H. Loh

ISBN #:

0824304357

Author:

Horace H. Loh

ISBN #:

0824304365

Author:

Horace H. Loh

ISBN #:

0824304373

Author:

Horace H. Loh

ISBN #:

0890041660