Holly Kay King

US Patent:

20080009019, Jan 10, 2008

Filed:

Jan 17, 2007

Appl. No.:

11/623983

Inventors:

Jill Haizlip - Durham NC, US
Diane Ignar - Durham NC, US
Channa Jayawickreme - Durham NC, US
Holly King - Durham NC, US
James Liacos - Durham NC, US
Kirsten Mills - Stevenage, GB
Jason Ruan - Cambridge MA, US
Howard Sauls - Durham NC, US
Joel Shaffer - Durham NC, US

Assignee:

SmithKline Beecham Corporation - Philadelphia PA

International Classification:

G01N 33/567
G01N 33/53
G01N 33/543

US Classification:

435007200, 435007100, 436518000

Abstract:

A method for screening candidate compounds for an ability to modulate the biological activity of a target. The method includes the steps of providing a substrate comprising a target and an indicator, the substrate adapted for receiving a plurality of candidate compounds; contacting the substrate with a plurality of candidate compound samples in a manner wherein an identity of each candidate compound can be determined and wherein the candidate compounds in the candidate compound samples interact with the target in the substrate; detecting a signal, the signal produced by the indicator upon interaction between the target and a candidate compound; and identifying a candidate compound as a modulator of the biological activity of the target based upon an amount of signal produced.

US Patent:

20030219825, Nov 27, 2003

Filed:

Dec 12, 2002

Appl. No.:

10/297976

Inventors:

Jill Haizlip - Durham NC, US
Diane Ignar - Durham NC, US
Channa Jayawickreme - Durham NC, US
Holly King - Durham NC, US
James Liacos - Durham NC, US
Kirsten Mills - Research Triangle Park NC, US
Jason Ruan - Cambridge MA, US
Howard Sauls Jr - Durham NC, US
Joel Shaffer - Durham NC, US

International Classification:

G01N033/53
G01N033/567
G01N033/543

US Classification:

435/007100, 435/007200, 436/518000

Abstract:

A method for screening candidate compounds for an ability to modulate the biological activity of a target. The method includes the steps of providing a substrate comprising a target and an indicator, the substrate adapted for receiving a plurality of candidate compounds; contacting the substrate with a plurality of candidate compound samples in a manner wherein an identity of each candidate compound can be determined and wherein the candidate compounds in the candidate compound samples interact with the target in the substrate; detecting a signal, the signal produced by the indicator upon interaction between the target and a candidate compound; and identifying a candidate compound as a modulator of the biological activity of the target based upon an amount of signal produced.