Herve A Husson from Watertown, MA, age 58

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Position:

staff Scientist at Genzyme

Location:

Greater Boston Area

Industry:

Biotechnology

Work:

Genzyme
staff Scientist

Methods And Compositions For The Treatment Of Polycystic Diseases
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US Patent:

20080193443, Aug 14, 2008
Filed:

Oct 30, 2006
Appl. No.:

11/589495
Inventors:

Oxana Beskrovnaya - Southboro MA, US
Herve Husson - Boston MA, US
International Classification:

A61K 39/395
C12N 5/00
A61P 13/12
A61K 48/00
US Classification:

4241331, 435375, 514 44, 4241301, 4241411
Abstract:

This invention provides compositions and methods to diagnose and treat polycystic disorders by inhibiting the biological activity of a gene now correlated with appearance of this disorder. By way of illustrative only, the Connective Tissue Growth Factor (CTGF) gene is an example of such a gene. Also provided by this invention are compositions and methods to treat or ameliorate abnormal cystic lesions and diseases associated with the formation of cysts in tissue. The methods and compositions treat and ameliorate pathological cyst formation in tissue by inhibiting or augmenting gene expression or the biological activity of its gene expression product or its receptor.

Glucosylceramide Synthase Inhibitors
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US Patent:

20180065957, Mar 8, 2018
Filed:

Apr 18, 2017
Appl. No.:

15/490385
Inventors:

- Cambrdige MA, US
Cassandra CELATKA - Hull MA, US
Seng H. CHENG - Natick MA, US
Bradford Hirth - Littleton MA, US
Andrew GOOD - Wallingford CT, US
Katherine JANCSICS - Wilmington MA, US
John MARSHALL - Charlestown MA, US
Markus Metz - Encinitas CA, US
Ronald K. SCHEULE - Hopkinton MA, US
Renato SKERLJ - W. Newton MA, US
Yibin XIANG - Dracut MA, US
Zhong ZHAO - Wayland MA, US
John LEONARD - Manchester NH, US
Thomas NATOLI - Revere MA, US
Elina MAKINO - Winchester MA, US
Herve HUSSON - Boston MA, US
Oxana BESKROVNAYA - Southborough MA, US
Assignee:

Genzyme Corporation - Cambrdige MA
International Classification:

C07D 453/02
C07D 471/08
A61K 45/06
A61K 31/551
A61K 31/55
A61K 31/496
A61K 31/497
A61K 31/506
A61K 31/5377
A61K 31/439
Abstract:

The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, cystic disease and for the treatment of cancer.

Glucosylceramide Synthase Inhibitors
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US Patent:

20150210681, Jul 30, 2015
Filed:

Sep 10, 2013
Appl. No.:

14/427275
Inventors:

- Cambridge MA, US
Cassandra Celatka - Chesterfield MA, US
Seng H. Cheng - Wellesley MA, US
Bradford Hirth - Littleton MA, US
Andrew Good - Wallingford CT, US
Katherine Jancsics - Wilmington MA, US
John Marshall - Hopedale MA, US
Markus Metz - Waltham MA, US
Ronald K. Scheule - Hopkinton MA, US
Renato Skerlj - Newton MA, US
Yibin Xiang - Dracut MA, US
Zhong Zhao - Wayland MA, US
John Leonard - Bridgewater NJ, US
Thomas Natoli - Southborough MA, US
Elina Makino - Winchester MA, US
Herve Husson - Boston MA, US
Oxana Beskrovnaya - Southborough MA, US
Assignee:

GENZYME CORPORATION - Cambrdige MA
International Classification:

C07D 453/02
C07D 471/08
A61K 31/55
A61K 45/06
A61K 31/506
A61K 31/497
A61K 31/439
A61K 31/5377
A61K 31/496
A61K 31/551
Abstract:

The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, cystic disease and for the treatment of cancer.

Herve A Husson