Herman H Hoeksema

Author:

Herman Hoeksema

ISBN #:

0825428092

Author:

Herman Hoeksema

ISBN #:

0825428130

Author:

Herman Hoeksema

ISBN #:

0825428173

Author:

Herman Hoeksema

ISBN #:

0916206254

Author:

Herman Hoeksema

ISBN #:

0916206262

Author:

Herman Hoeksema

ISBN #:

0916206572

Author:

Herman Hoeksema

ISBN #:

0916206580

Author:

Herman Hoeksema

ISBN #:

0916206653

US Patent:

41549384, May 15, 1979

Filed:

Aug 31, 1978

Appl. No.:

5/938689

Inventors:

Herman Hoeksema - Kalamazoo MI

Assignee:

The Upjohn Company - Kalamazoo MI

International Classification:

C07D40514

US Classification:

546269

Abstract:

Disclosed are degradation products of the antibiotics rubradirin and rubradirin B and processes for their preparation. Some of these products have antibacterial activity, and, thus, can be used in various environments to inhibit susceptible bacteria. Also, some of these products can be used as intermediates to make useful antibacterials.

US Patent:

41549392, May 15, 1979

Filed:

Aug 31, 1978

Appl. No.:

5/938602

Inventors:

Herman Hoeksema - Kalamazoo MI

Assignee:

The Upjohn Company - Kalamazoo MI

International Classification:

C07D40514

US Classification:

546269

Abstract:

Disclosed are degradation products of the antibiotics rubradirin and rubradirin B and processes for their preparation. Some of these products have antibacterial activity, and, thus, can be used in various environments to inhibit susceptible bacteria. Also, some of these products can be used as intermediates to make useful antibacterials.

US Patent:

41995074, Apr 22, 1980

Filed:

Aug 31, 1978

Appl. No.:

5/938688

Inventors:

Herman Hoeksema - Kalamazoo MI

Assignee:

The Upjohn Company - Kalamazoo MI

International Classification:

C07D26352

US Classification:

548218

Abstract:

Disclosed are degradation products of the antibiotics rubradirin and rubradirin B and processes for their preparation. Some of these products have antibacterial activity, and, thus, can be used in various environments to inhibit susceptible bacteria. Also, some of these products can be used as intermediates to make useful antibacterials.

US Patent:

42207860, Sep 2, 1980

Filed:

Aug 31, 1978

Appl. No.:

5/938685

Inventors:

Herman Hoeksema - Kalamazoo MI

International Classification:

C07D49704

US Classification:

548218

Abstract:

Disclosed are degradation products of the antibiotics rubradirin and rubradirin B and processes for their preparation. Some of these products have antibacterial activity, and, thus, can be used in various environments to inhibit susceptible bacteria. Also, some of these products can be used as intermediates to make useful antibacterials.

US Patent:

41828550, Jan 8, 1980

Filed:

Aug 31, 1978

Appl. No.:

5/938606

Inventors:

Herman Hoeksema - Kalamazoo MI

Assignee:

The Upjohn Company - Kalamazoo MI

International Classification:

C07H 504

US Classification:

536 1

Abstract:

Disclosed are degradation products of the antibiotics rubradirin and rubradirin B and processes for their preparation. Some of these products have antibacterial activity, and, thus, can be used in various environments to inhibit susceptible bacteria. Also, some of these products can be used as intermediates to make useful antibacterials.

US Patent:

41072960, Aug 15, 1978

Filed:

Jun 29, 1977

Appl. No.:

5/810955

Inventors:

Herman Hoeksema - Kalamazoo MI
Fritz Reusser - Portage MI

Assignee:

The Upjohn Company - Kalamazoo MI

International Classification:

A61K 3500

US Classification:

424121

Abstract:

Antibiotic rubradirin C producible by the controlled fermentation of the known microorganism Streptomyces achromogenes var. rubradiris, NRRL 3061. This antibiotic and its base-addition salts are active against Streptococcus pyogenes and Bacillus cereus. Accordingly, they can be used in various environments to eradicate or control such microorganisms. Su BACKGROUND OF THE INVENTION Antibiotic rubradirin, and a microbiological process for its preparation, are disclosed in U. S. Pat. No. 3,335,057. Rubradirin B is disclosed in U. S. application Ser. No. 787,833, filed Apr. 15, 1977. Degradation products of rubradirin and rubradirin B, and processes for their preparation are disclosed in U. S. application Ser. No. 793,785, filed May 5, 1977.

US Patent:

43316590, May 25, 1982

Filed:

Sep 10, 1980

Appl. No.:

6/185130

Inventors:

Herman Hoeksema - Kalamazoo MI
Libor Slechta - Kalamazoo MI

Assignee:

The Upjohn Company - Kalamazoo MI

International Classification:

A61K 3500
C12P 106
C12R 1465
A61K 3574

US Classification:

424122

Abstract:

Novel antibiotic U-62,162 producible in a fermentation under controlled conditions using a man-made biologically pure culture of the microorganism Streptomyces verdensis, Dietz and Li sp. n. , NRRL 12256. This antibiotic is strongly active against various Gram-positive bacteria, for example, Staphylococcus aureus. Thus, antibiotic U-62,162 can be used in various environments to eradicate or control such bacteria.

US Patent:

41549406, May 15, 1979

Filed:

Aug 31, 1978

Appl. No.:

5/938687

Inventors:

Herman Hoeksema - Kalamazoo MI

Assignee:

The Upjohn Company - Kalamazoo MI

International Classification:

C07D40514

US Classification:

546269

Abstract:

Disclosed are degradation products of the antibiotics rubradirin and rubradirin B and processes for their preparation. Some of these products have antibacterial activity, and, thus, can be used in various environments to inhibit susceptible bacterial. Also, some of these products can be used as intermediates to make useful antibacterials.