Heather J Finlay

US Patent:

6511977, Jan 28, 2003

Filed:

Sep 25, 2000

Appl. No.:

09/670285

Inventors:

John Lloyd - Yardley PA
Heather J. Finlay - Lawrenceville NJ
Wayne Vaccaro - Yardley PA
Karnail S. Atwal - Newtown PA
Michael F. Gross - Durham NC
Kerry L. Spear - Raleigh NC

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C07D491052

US Classification:

5142338, 51425214, 51425218, 51425304, 514302, 544127, 544331, 544362, 546115, 546116

Abstract:

Indanes, benzopyrans and analogues thereof are potassium channel inhibitors and blockers of IKur and have the structure where A, B, D, Q, X , R, R , X and R are as defined herein. These compounds are useful as antiarrhythmic agents. In addition, a method is provided for preventing cardiac arrhythmia employing the above compounds.

US Patent:

6706720, Mar 16, 2004

Filed:

Dec 5, 2000

Appl. No.:

09/729731

Inventors:

Karnail S. Atwal - Newtown PA
Wayne Vaccaro - Yardley PA
John Lloyd - Yardley PA
Heather Finlay - Lawrenceville NJ
Lin Yan - Princeton NJ
Rao S. Bhandaru - Belle Mead NJ

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C07D48704

US Classification:

5142593, 514183, 51421706, 5142332, 51425216, 540481, 540600, 544117, 544281

Abstract:

Novel heterocyclic dihydropyrimidine compounds useful as inhibitors of potassium channel function (especially inhibitors of the K 1 subfamily of voltage gated K channels, especially inhibitors K 1. 5 which has been linked to the ultra-rapidly activating delayed rectifier K current I ), methods of using such compounds in the prevention and treatment of arrhythmia and I -associated conditions, and pharmaceutical compositions containing such compounds.

US Patent:

6784189, Aug 31, 2004

Filed:

Nov 15, 2002

Appl. No.:

10/295404

Inventors:

John Lloyd - Yardley PA
Heather J. Finlay - Lawrenceville NJ
Wayne Vaccaro - Yardley PA
Karnail S. Atwal - Newtown PA
Michael F. Gross - Durham NC
Kerry L. Spear - Raleigh NC

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C07D21520

US Classification:

514312, 514313, 546153, 546162, 546165

Abstract:

Indanes, benzopyrans and analogues thereof are potassium channel inhibitors and blockers of IKur and have the structure where A, B, D, Q, X , R, R , X and R are as defined herein. These compounds are useful as antiarrhythmic agents. In addition, a method is provided for preventing cardiac arrhythmia employing the above compounds.

US Patent:

6881753, Apr 19, 2005

Filed:

Apr 14, 2004

Appl. No.:

10/823987

Inventors:

John Lloyd - Yardley PA, US
Heather J. Finlay - Lawrenceville NJ, US
Wayne Vaccaro - Yardley PA, US
Karnail S. Atwal - Newtown PA, US
Michael F. Gross - Durham NC, US
Kerry L. Spear - Raleigh NC, US

Assignee:

Bristol-Myers Squibb Co. - Princeton NJ

International Classification:

C07C279/28
C07C279/18
A61K031/155

US Classification:

514604, 514243, 514248, 5142581, 5142664, 514310, 514313, 564 91, 546141, 546143, 546153, 546162, 546163, 544183, 544235, 544253, 544283, 544292, 544293

Abstract:

Indanes, benzopyrans and analogues thereof are potassium channel inhibitors and blockers of IKur and have the structure: where A, B, D, Q, X, R, R, Xand Rare as defined herein. These compounds are useful as antiarrhythmic agents. In addition, a method is provided for preventing cardiac arrhythmia employing the above compounds.

US Patent:

7005436, Feb 28, 2006

Filed:

Apr 16, 2003

Appl. No.:

10/417355

Inventors:

John Lloyd - Yardley PA, US
Yoon T. Jeon - Belle Meade NJ, US
Heather Finlay - Skillman NJ, US
Lin Yan - East Brunswick NJ, US
Michael F. Gross - Durham NC, US
Serge Beaudoin - Morrisville NC, US

Assignee:

Bristol Myers Squibb Company - Princeton NJ
Icagen, Inc. - Durham NC

International Classification:

A61K 31/495
A61K 31/44
C07D 241/02
C07D 211/174

US Classification:

514317, 5142521, 544336, 546188, 546191

Abstract:

Novel heterocyclo compounds useful as inhibitors of potassium channel function (especially inhibitors of the K1 subfamily of voltage gated K channels, especially inhibitors K1. 5 which has been linked to the ultra-rapidly activating delayed rectifier K current I), methods of using such compounds in the prevention and treatment of arrhythmia and I-associated conditions, and pharmaceutical compositions containing such compounds.

US Patent:

7157451, Jan 2, 2007

Filed:

Sep 12, 2003

Appl. No.:

10/660878

Inventors:

Karnail S. Atwal - Newtown PA, US
Wayne Vaccaro - Yardley PA, US
John Lloyd - Yardley PA, US
Heather Finlay - Lawrenceville NJ, US
Lin Yan - Princeton NJ, US
Rao S. Bhandaru - Belle Mead NJ, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C07D 401/06
A61K 31/4025
A61K 31/4162
C07D 487/04

US Classification:

51421706, 514183, 5142285, 5142332, 51425216, 5142593, 540481, 540600, 544 61, 544117, 544281

Abstract:

Novel heterocyclic dihydropyrimidine compounds useful as inhibitors of potassium channel function (especially inhibitors of the K1 subfamily of voltage gated K channels, especially inhibitors K1. 5 which has been linked to the ultra-rapidly activating delayed rectifier K current I), methods of using such compounds in the prevention and treatment of arrhythmia and I-associated conditions, and pharmaceutical compositions containing such compounds.

US Patent:

7202253, Apr 10, 2007

Filed:

Nov 24, 2004

Appl. No.:

10/997734

Inventors:

John Lloyd - Yardley PA, US
Yoon T. Jeon - Belle Meade NJ, US
Heather Finlay - Skillman NJ, US
Lin Yan - East Brunswick NJ, US
Michael F. Gross - Durham NC, US
Serge Beaudoin - Morrisville NC, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ
Icagen, Inc. - Durham NC

International Classification:

A61K 31/4709
A61K 31/519
C07D 217/22
C07D 239/84
C07D 471/06

US Classification:

5142664, 514300, 514310, 544293, 546122, 546143

Abstract:

Novel cycloalkyl compounds useful as inhibitors of potassium channel function (especially inhibitors of the K1 subfamily of voltage gated K channels, especially inhibitors K1. 5 which has been linked to the ultra-rapidly activating delayed rectifier K current I), methods of using such compounds in the prevention and treatment of arrhythmia and I-associated conditions, and pharmaceutical compositions containing such compounds.

US Patent:

7541362, Jun 2, 2009

Filed:

Dec 6, 2006

Appl. No.:

11/634574

Inventors:

Karnail S. Atwal - Newtown PA, US
Wayne Vaccaro - Yardley PA, US
John Lloyd - Yardley PA, US
Heather Finlay - Lawrenceville NJ, US
Lin Yan - Princeton NJ, US
Rao S. Bhandaru - Belle Mead NJ, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C07D 401/06
A61K 31/4025

US Classification:

5142593, 544281

Abstract:

Novel heterocyclic dihydropyrimidine compounds useful as inhibitors of potassium channel function (especially inhibitors of the K1 subfamily of voltage gated K channels, especially inhibitors K1. 5 which has been linked to the ultra-rapidly activating delayed rectifier K current I), methods of using such compounds in the prevention and treatment of arrhythmia and I-associated conditions, and pharmaceutical compositions containing such compounds.