Steven E. Hobbs - West Hills CA, US Hau H. Duong - Pasadena CA, US Scott G. Beach - Manhattan Beach CA, US
Assignee:
Nanostream, Inc. - Pasadena CA
International Classification:
B01D015/08
US Classification:
2101982, 210656, 210143, 422 70, 422100
Abstract:
Systems and methods for performing multiple parallel chromatographic separations are provided. Microfluidic cartridges containing multiple separation columns allow multiple separations to be performed in a limited space by a single instrument containing high-pressure pumps and analyte detectors. The use of pressure fit interfaces allows the microfluidic cartridges to easily be removed and replaced within the instrument, either manually or robotically.
Steven E. Hobbs - West Hills CA, US Hau H. Duong - Pasadena CA, US
Assignee:
Nanostream, Inc. - Pasadena CA
International Classification:
G01N030/00
US Classification:
73 6158, 73 6152
Abstract:
High throughput liquid chromatography systems include multiple separation columns and multiple flow-through detection regions in sensory communication with a common radiation source and a multi-channel detector. Preferred detector types include a multi-anode photomultiplier tube, a charge-coupled device detector, a diode array, and a photodiode array. In certain embodiments, separation columns are microfluidic and integrated into a unitary microfluidic device. The optical path through a detection region is preferably coaxial with the path of eluate flow along a flow axis through a detection region. On-board or off-board detection regions may be provided.
Gary Blackburn - Glendora CA, US Hau H. Duong - Los Angeles CA, US Piotr Grodzinski - Chandler AZ, US Jon Faiz Kayyem - Pasadena CA, US Stephen D. O'Connor - Pasadena CA, US Robert Pietri - Pasadena CA, US Robert Henry Terbrueggen - Manhattan Beach CA, US Frederic Zenhausern - Fountain Hills AZ, US Gary T. Olsen - La Crescenta CA, US
Assignee:
Clinical Micro Sensors, Inc. - Pasadena CA
International Classification:
C12M 1/34
US Classification:
4352872, 20440302, 20440303, 204406
Abstract:
The invention is directed to devices that allow for simultaneous multiple biochip analysis. In particular, the devices are configured to hold multiple cartridges comprising biochips comprising arrays such as nucleic acid arrays, and allow for high throughput analysis of samples.
Hau H. Duong - Los Angeles CA, US Gary Blackburn - Glendora CA, US Jon F. Kayyem - Pasadena CA, US Stephen D. O'Connor - Pasadena CA, US Gary T. Olsen - La Cresenta CA, US Robert Pietri - Pasadena CA, US Robert H. Terbrueggen - Manhattan Beach CA, US
The invention is directed to devices and methods that allow for simultaneous multiple biochip analysis. The method of analyzing the plurality of biochips includes inserting a first biochp into a first station of an analysis device, inserting a second biochip into a second station of the analysis device, wherein each of the first and second biochips include a substrate, the substrates including an array of detection electrodes, each electrode including a different capture binding ligand, a different target analyte, and a label, and a plurality of electrical contracts, detecting current as an indication of the presence of the labels on the first biochip, and detecting current as an indication of the presence of the labels on the first second biochip. The devices and method may be used with multiple cartridges comprising biochips comprising arrays, such as nucleic acid arrays, and allow for high throughput analysis of samples.
Signal Detection Techniques For The Detection Of Analytes
Hau Duong - Los Angeles CA, US Stephen O'Connor - Pasadena CA, US Robert Terbrueggen - Manhattan Beach CA, US Jon Kayyem - Pasadena CA, US Gary Olsen - La Crescenta CA, US Daniel Litvack - Sherman Oaks CA, US Javier Gonzalez - Pasadena CA, US
International Classification:
C12Q001/68 G06F019/00 G01N033/48 G01N033/50
US Classification:
435/006000, 702/020000
Abstract:
The invention relates to the use of signal processing methods in order to acheive higher signal to noise ratios, to increase the detection limits of target analytes. These techniques include the monitoring of the output signal at higher harmonic frequencies.
Hau H. DUONG - Los Angeles CA, US Gary Blackburn - Glendora CA, US Jon F. Kayyem - Pasadena CA, US Stephen D. O'Connor - Pasadena CA, US Gary T. Olsen - La Crescenta CA, US Robert Pietri - Pasadena CA, US Robert H. Terbrueggen - Manhattan Beach CA, US
International Classification:
C12M 1/34
US Classification:
4352872
Abstract:
The invention is directed to a method of analyzing a plurality of biochips. In particular, the method includes inserting a first biochip in to a first station of an analysis device, inserting a second biochip into a second station of the analysis device, wherein each of the first and second biochips comprise a substrate that includes an array of detection electrodes, each including a different capture binding ligand, a different target analyte, and a label, and a plurality of electrical contacts, detecting current as an indication of the presence of the labels on the first biochip and detecting current as an indication of the presence of the labels on the second biochip.
Signal Detection Techniques For The Detection Of Analytes
Hau H. Duong - Los Angeles CA Stephen D. OConnor - Pasadena CA Robert H. Terbrueggen - Manhattan Beach CA Jon Faiz Kayyem - Pasadena CA Gary T. Olsen - La Crescenta CA Daniel A. Litvack - Sherman Oaks CA Javier Gonzalez - Pasadena CA
Assignee:
Clinical Micro Sensors, Inc. - Pasadena CA
International Classification:
C12M 134
US Classification:
4352872, 435 6, 435 71, 435 911, 4352871
Abstract:
The invention relates to the use of signal processing methods in order to acheive higher signal to noise ratios, to increase the detection limits of target analytes. These techniques include the monitoring of the output signal at higher harmonic frequencies.
SAFCell, Inc. since 2009
Chief Operating Officer
HDC since 2007
Managing Consultant
LTC 2008 - 2010
Board Member of Technical Advisory Committee
Superprotonic 2008 - 2009
Vice President of Product Development
Gyrus ACMI, A Group Company of Olympus Corp. 2006 - 2007
Vice President of R&D
Education:
University of Ottawa / Université d'Ottawa 1996 - 1997
University of California, Irvine 1987 - 1993
University of California, Los Angeles 1983 - 1987
Skills:
Product Development Cross Functional Team Leadership R&D Medical Devices Start Ups Strategic Planning Commercialization Program Management Fda Product Management Manufacturing Project Management Biotechnology Lifesciences Technology Transfer Quality Assurance Iso Patents Life Sciences Organizational Development Electronic Instrumentation
Languages:
Vietnamese English French
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