Hau Hoang Duong

US Patent:

6936167, Aug 30, 2005

Filed:

Oct 28, 2003

Appl. No.:

10/696354

Inventors:

Steven E. Hobbs - West Hills CA, US
Hau H. Duong - Pasadena CA, US
Scott G. Beach - Manhattan Beach CA, US

Assignee:

Nanostream, Inc. - Pasadena CA

International Classification:

B01D015/08

US Classification:

2101982, 210656, 210143, 422 70, 422100

Abstract:

Systems and methods for performing multiple parallel chromatographic separations are provided. Microfluidic cartridges containing multiple separation columns allow multiple separations to be performed in a limited space by a single instrument containing high-pressure pumps and analyte detectors. The use of pressure fit interfaces allows the microfluidic cartridges to easily be removed and replaced within the instrument, either manually or robotically.

US Patent:

6976384, Dec 20, 2005

Filed:

Oct 30, 2003

Appl. No.:

10/699533

Inventors:

Steven E. Hobbs - West Hills CA, US
Hau H. Duong - Pasadena CA, US

Assignee:

Nanostream, Inc. - Pasadena CA

International Classification:

G01N030/00

US Classification:

73 6158, 73 6152

Abstract:

High throughput liquid chromatography systems include multiple separation columns and multiple flow-through detection regions in sensory communication with a common radiation source and a multi-channel detector. Preferred detector types include a multi-anode photomultiplier tube, a charge-coupled device detector, a diode array, and a photodiode array. In certain embodiments, separation columns are microfluidic and integrated into a unitary microfluidic device. The optical path through a detection region is preferably coaxial with the path of eluate flow along a flow axis through a detection region. On-board or off-board detection regions may be provided.

US Patent:

7172897, Feb 6, 2007

Filed:

Nov 5, 2001

Appl. No.:

09/993342

Inventors:

Gary Blackburn - Glendora CA, US
Hau H. Duong - Los Angeles CA, US
Piotr Grodzinski - Chandler AZ, US
Jon Faiz Kayyem - Pasadena CA, US
Stephen D. O'Connor - Pasadena CA, US
Robert Pietri - Pasadena CA, US
Robert Henry Terbrueggen - Manhattan Beach CA, US
Frederic Zenhausern - Fountain Hills AZ, US
Gary T. Olsen - La Crescenta CA, US

Assignee:

Clinical Micro Sensors, Inc. - Pasadena CA

International Classification:

C12M 1/34

US Classification:

4352872, 20440302, 20440303, 204406

Abstract:

The invention is directed to devices that allow for simultaneous multiple biochip analysis. In particular, the devices are configured to hold multiple cartridges comprising biochips comprising arrays such as nucleic acid arrays, and allow for high throughput analysis of samples.

US Patent:

7312087, Dec 25, 2007

Filed:

Jan 11, 2001

Appl. No.:

09/760384

Inventors:

Hau H. Duong - Los Angeles CA, US
Gary Blackburn - Glendora CA, US
Jon F. Kayyem - Pasadena CA, US
Stephen D. O'Connor - Pasadena CA, US
Gary T. Olsen - La Cresenta CA, US
Robert Pietri - Pasadena CA, US
Robert H. Terbrueggen - Manhattan Beach CA, US

Assignee:

Clinical Micro Sensors, Inc. - Pasadena CA

International Classification:

C12Q 1/68
G01N 15/06
G01N 33/00
G01N 33/48
G01N 35/00

US Classification:

436149, 422 50, 422 681, 422 8201, 422 8205, 436 43, 436 63, 436 64, 436 66, 436150, 205775, 205792, 2057935, 204164, 204461, 204193, 204194, 204400, 20440301, 20440302, 20440303, 204406, 204407

Abstract:

The invention is directed to devices and methods that allow for simultaneous multiple biochip analysis. The method of analyzing the plurality of biochips includes inserting a first biochp into a first station of an analysis device, inserting a second biochip into a second station of the analysis device, wherein each of the first and second biochips include a substrate, the substrates including an array of detection electrodes, each electrode including a different capture binding ligand, a different target analyte, and a label, and a plurality of electrical contracts, detecting current as an indication of the presence of the labels on the first biochip, and detecting current as an indication of the presence of the labels on the first second biochip. The devices and method may be used with multiple cartridges comprising biochips comprising arrays, such as nucleic acid arrays, and allow for high throughput analysis of samples.

US Patent:

20040146909, Jul 29, 2004

Filed:

Nov 14, 2003

Appl. No.:

10/714489

Inventors:

Hau Duong - Los Angeles CA, US
Stephen O'Connor - Pasadena CA, US
Robert Terbrueggen - Manhattan Beach CA, US
Jon Kayyem - Pasadena CA, US
Gary Olsen - La Crescenta CA, US
Daniel Litvack - Sherman Oaks CA, US
Javier Gonzalez - Pasadena CA, US

International Classification:

C12Q001/68
G06F019/00
G01N033/48
G01N033/50

US Classification:

435/006000, 702/020000

Abstract:

The invention relates to the use of signal processing methods in order to acheive higher signal to noise ratios, to increase the detection limits of target analytes. These techniques include the monitoring of the output signal at higher harmonic frequencies.

US Patent:

20100028984, Feb 4, 2010

Filed:

Jul 17, 2007

Appl. No.:

11/779024

Inventors:

Hau H. DUONG - Los Angeles CA, US
Gary Blackburn - Glendora CA, US
Jon F. Kayyem - Pasadena CA, US
Stephen D. O'Connor - Pasadena CA, US
Gary T. Olsen - La Crescenta CA, US
Robert Pietri - Pasadena CA, US
Robert H. Terbrueggen - Manhattan Beach CA, US

International Classification:

C12M 1/34

US Classification:

4352872

Abstract:

The invention is directed to a method of analyzing a plurality of biochips. In particular, the method includes inserting a first biochip in to a first station of an analysis device, inserting a second biochip into a second station of the analysis device, wherein each of the first and second biochips comprise a substrate that includes an array of detection electrodes, each including a different capture binding ligand, a different target analyte, and a label, and a plurality of electrical contacts, detecting current as an indication of the presence of the labels on the first biochip and detecting current as an indication of the presence of the labels on the second biochip.

US Patent:

6740518, May 25, 2004

Filed:

Sep 17, 1999

Appl. No.:

09/397957

Inventors:

Hau H. Duong - Los Angeles CA
Stephen D. OConnor - Pasadena CA
Robert H. Terbrueggen - Manhattan Beach CA
Jon Faiz Kayyem - Pasadena CA
Gary T. Olsen - La Crescenta CA
Daniel A. Litvack - Sherman Oaks CA
Javier Gonzalez - Pasadena CA

Assignee:

Clinical Micro Sensors, Inc. - Pasadena CA

International Classification:

C12M 134

US Classification:

4352872, 435 6, 435 71, 435 911, 4352871

Abstract:

The invention relates to the use of signal processing methods in order to acheive higher signal to noise ratios, to increase the detection limits of target analytes. These techniques include the monitoring of the output signal at higher harmonic frequencies.