Vincent C. Bond - Stone Mountain GA, US James Lillard - Smyrna GA, US Ming Bo Huang - Atlanta GA, US Harvey Bumpers - Stone Mountain GA, US Michael Powell - Douglasville GA, US
Assignee:
Morehouse School of Medicine - Atlanta GA
International Classification:
C07K 4/02
US Classification:
530328, 514 15
Abstract:
The present invention provides a means of selectively killing epithelial cell carcinomas by administering a CXCR4-specific sequence of the Gp120 protein or Nef proteins or the proteins themselves (the modulators) such as that found in strains HIV-1, HIV-2, SIV, or FIV CXCR4-specific Gp 120 sequences or Nef proteins or sequences may be delivered to the mucosa or systemically. The mucosal means of application include oral, intranasal, ocular, intravaginal, rectal, and/or intraurethral administration in liquid or particulate form.
Tumor Cytotoxicity Induced By Modulators Of The Cxcr4 Receptor
Vincent C. Bond - Stn Mtn. GA, US James W. Lillard - Smyrna GA, US Ming Bo Huang - Atlanta GA, US Harvey Bumpers - Stone Mountain GA, US Michael Powell - Douglasville GA, US
The present invention provides a means of selectively killing epithelial cell carcinomas by administering a CXCR4-specific sequence of the Gp120 protein or Nef proteins or the proteins themselves (the modulators) such as that found in strains HIV-1, HIV-2, SIV, or FIV CXCR4-specific Gp 120 sequences or Nef proteins or sequences may be delivered to the mucosa or systemically. The mucosal means of application include oral, intranasal, ocular, intravaginal, rectal, and/or intraurethral administration in liquid or particulate form.
Elizabeth Repasky Subjeck - Williamsville NY Heather Sechrist - Seattle WA Harvey L. Bumpers - Stone Mountain GA
Assignee:
Corixa Corporation - Seattle WA
International Classification:
A61K 4900 A61K 6700 G01N 3300
US Classification:
424 9321
Abstract:
A murine model for human breast, ovarian and prostate cancer is provided. The model comprises either an immunodeficient mouse containing human primary breast, ovarian or prostate carcinoma tissue implanted within the gonadal fat pad, or an immunodeficient mouse containing human prostate or ovarian carcinoma tissue subcutaneously implanted therein. Methods of using the murine model, for example, to grow tumors and to screen treatments for breast, ovarian and/or prostate cancer are also provided.
Medicine Doctors
Dr. Harvey Bumpers, Atlanta GA - MD (Doctor of Medicine)
720 Westview Dr Sw, Atlanta, GA 30310 404 616-1415 (Phone)
80 Jesse Hill Jr Drive North East, Atlanta, GA 30303 404 616-4307 (Phone), 404 616-1417 (Fax)
Morehouse School Of Medcn Sgy 80 Jesse Hill Jr Dr Se Suite 7B, Atlanta, GA 30303 404 616-1415 (Phone)
Procedures:
Biopsy of Breast Colectomy Dressing and/or Debridement of Wound, Infection, or Burn (incl. Negative Pressure Wound Therapy) Excision of Breast Tumor Intestinal Transplant (incl. Enterectomy) Lymph Node Biopsy or Excision Mastectomy Splenectomy Splenectomy and Splenorrhaphy
Conditions:
Anal and Rectal Cancer Breast Cancer Breast Lump/Mass Carcinoma in Situ Cholecystitis and Gallstones Colorectal Cancer Diaphragmatic/Hiatal Hernia Incisional Hernia Intestinal Obstruction Lipomas Liver Cancer Secondary Malignancies Stomach and Small Intestine Cancer Ventral Hernia
Certifications:
General Surgery, 1991
Awards:
Healthgrades Honor Roll
Languages:
English
Education:
Medical School University Of Rochester School Of Medicine and Dentistry Graduated: 1982