Harmon J Zuccola

US Patent:

7388070, Jun 17, 2008

Filed:

May 12, 2000

Appl. No.:

09/959948

Inventors:

Donald Coen - Medfield MA, US
James Hogle - Newton MA, US
Carl Elkin - Cambridge MA, US
Harmon J. Zuccola - Brookline MA, US
Kristie Grove Bridges - Maynard MA, US
Scott Lokey - Santa Cruz CA, US

Assignee:

President and Fellows of Harvard College - Cambridge MA

International Classification:

C07C 237/24
C07D 237/24
A61K 31/16
A61P 31/00
A61P 35/00

US Classification:

530232, 560116, 560117

Abstract:

A method for the structure-based identification and selection of inhibitors of processivity factor binding to protein is disclosed herein. Characterization of the protein/processivity factor interface is given. Methods for the structure-based inhibition of processivity factor binding to protein are also given. One embodiment includes a class of peptidomimetics that mimic helical portions of proteins. In addition, methods of treatment of various diseases are given, using the inhibitors of the invention.

US Patent:

7558717, Jul 7, 2009

Filed:

Apr 26, 2005

Appl. No.:

11/114979

Inventors:

Harmon Zuccola - Westwood MA, US
Marc Jacobs - Boston MA, US
Lovorka Swenson - Belmont MA, US
Kumkum Saxena - Framingham MA, US

Assignee:

Vertex Pharmaceuticals Incorporated - Cambridge MA

International Classification:

C12Q 1/00
C12Q 1/48
G01N 33/53
G01N 31/00
C12N 9/00
C12N 9/12
G06G 7/58

US Classification:

703 11, 435 76, 435 771, 435 15, 435183, 435194, 435 4, 702 27

Abstract:

The present invention relates to human Janus Kinase 3 (JAK3) and JAK3-like binding pockets. The present invention provides a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen for and design compounds, including inhibitory compounds, that bind to JAK3 protein or JAK3 protein homologues, or complexes thereof. The invention also relates to crystallizable compositions and crystals comprising JAK3 kinase domain and JAK3 kinase domain complexed with AMP-PNP.

US Patent:

8192972, Jun 5, 2012

Filed:

May 26, 2009

Appl. No.:

12/471896

Inventors:

Harmon Zuccola - Westwood MA, US
Marc Jacobs - Boston MA, US
Lovorka Swenson - Belmont MA, US
Kumkum Saxena - Framingham MA, US

Assignee:

Vertex Pharmaceuticals Incorporated - Cambridge MA

International Classification:

C12N 9/00
C12N 9/10

US Classification:

435183, 435194

Abstract:

The present invention relates to human Janus Kinase 3 (JAK3) and JAK3-like binding pockets. The present invention provides a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen for and design compounds, including inhibitory compounds, that bind to JAK3 protein or JAK3 protein homologues, or complexes thereof. The invention also relates to crystallizable compositions and crystals comprising JAK3 kinase domain and JAK3 kinase domain complexed with AMP-PNP.

US Patent:

20050170337, Aug 4, 2005

Filed:

Jan 18, 2005

Appl. No.:

11/038652

Inventors:

James Hogle - Newton MA, US
Harmon Zuccola - Brookline MA, US
David Filman - Auburndale MA, US
Carl Elkin - Cambridge MA, US

Assignee:

President and Fellows of Harvard College - Cambridge MA

International Classification:

C12Q001/70
C07H021/04
C07K014/02
C12N015/86

US Classification:

435005000, 435069300, 435456000, 435325000, 435235100, 530350000, 536023720

Abstract:

This invention relates to HDAg peptides, including mutants, derivatives fragments and fusion molecules, including fusion proteins, coiled-coil oligomers, nucleic acid molecules, vectors comprising HDAg nucleic acid molecules, cells comprising said molecules, methods of multivalent expression and association of binding moieties of HDAg fusion molecules, and methods of use involving the molecules. The molecules are particularly useful as a framework for multivalent display via formation of C-terminal and/or N-terminal fusion proteins or via chemical coupling to chemically reactive sidechains, e.g. cysteine residues.

US Patent:

20070055459, Mar 8, 2007

Filed:

Nov 6, 2006

Appl. No.:

11/592971

Inventors:

Donald Coen - Medfield MA, US
James Hogle - Newton MA, US
Carl Elkin - Cambridge MA, US
Harmon Zuccola - Brookline MA, US
Kristie Bridges - Arlington MA, US
Scott Lokey - Santa Cruz CA, US

International Classification:

C40B 30/02
C40B 30/06
G06F 19/00

US Classification:

702019000

Abstract:

A method for the structure-based identification and selection of inhibitors of processivity factor binding to protein is disclosed herein. Characterization of the protein/processivity factor interface is given. Methods for the structure-based inhibition of processivity factor binding to protein are also given. One embodiment includes a class of peptidomimetics that mimic helical portions of proteins. In addition, methods of treatment of various diseases are given, using the inhibitors of the invention.

US Patent:

20100298164, Nov 25, 2010

Filed:

Jul 2, 2010

Appl. No.:

12/829736

Inventors:

Donald Coen - Medfield MA, US
James Hogle - Newton MA, US
Carl Elkin - Cambridge MA, US
Harmon J. Zuccola - Brookline MA, US
Kristie Grove Bridges - Maynard MA, US
Scott Lokey - Santa Cruz CA, US

International Classification:

C40B 30/04

US Classification:

506 9

Abstract:

A method for the structure-based identification and selection of inhibitors of processivity factor binding to protein is disclosed herein. Characterization of the protein/processivity factor interface is given. Methods for the structure-based inhibition of processivity factor binding to protein are also given. One embodiment includes a class of peptidomimetics that mimic helical portions of proteins. In addition, methods of treatment of various diseases are given, using the inhibitors of the invention.

US Patent:

20130137125, May 30, 2013

Filed:

May 24, 2012

Appl. No.:

13/479720

Inventors:

Harmon Zuccola - Westwood MA, US
Marc Jacobs - Boston MA, US
Lovorka Swenson - Belmont MA, US
Kumkum Saxena - Framingham MA, US

Assignee:

VERTEX PHARMACEUTICALS INCORPORATED - CAMBRIDGE MA

International Classification:

C12Q 1/48

US Classification:

435 15, 435194

Abstract:

The present invention relates to human Janus Kinase 3 (JAK3) and JAK3-like binding pockets. The present invention provides a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen for and design compounds, including inhibitory compounds, that bind to JAK3 protein or JAK3 protein homologues, or complexes thereof. The invention also relates to crystallizable compositions and crystals comprising JAK3 kinase domain and JAK3 kinase domain complexes with AMP-PNP.

US Patent:

6844171, Jan 18, 2005

Filed:

Jul 1, 1999

Appl. No.:

09/347175

Inventors:

James M. Hogle - Newton MA, US
Harmon J. Zuccola - Brookline MA, US
David Filman - Auburndale MA, US
Carl Elkin - Cambridge MA, US

Assignee:

President and Fellows of Harvard College - Cambridge MA

International Classification:

C12P 2102

US Classification:

435 697, 435 5, 435 41, 435 693, 530350

Abstract:

This invention relates to HDAg peptides, including mutants, derivatives fragments and fusion molecules, including fusion proteins, coiled-coil oligomers, nucleic acid molecules, vectors comprising HDAg nucleic acid molecules, cells comprising said molecules, methods of multivalent expression and association of binding moieties of HDAg fusion molecules, and methods of use involving the molecules. The molecules are particularly useful as a framework for multivalent display via formation of C-terminal and/or N-terminal fusion proteins or via chemical coupling to chemically reactive sidechains, e. g. cysteine residues.