Hariharan Venkatesan

US Patent:

6399783, Jun 4, 2002

Filed:

Aug 25, 2000

Appl. No.:

09/645766

Inventors:

Dennis C. Liotta - McDonough GA
Hariharan Venkatesan - Atlanta GA
Laura Captain - Durham NC
Michael V. Voronkov - Gainseville FL
James P. Snyder - Atlanta GA
Marcus A. Schestopol - Atlanta GA

Assignee:

Emory University - Atlanta GA

International Classification:

C07D23304

US Classification:

548110, 548188, 548194, 548230, 548233, 5483225, 5483321

Abstract:

The invention relates to a method for preparing an ester, by admixing a compound having the structure I or IV: with a base and an alcohol to produce an ester, wherein the alcohol is a precursor to Taxol and its analogs. The present invention also relates to compounds having the structure I and IV and methods of main them therefor. The invention also relates to the esterification of an alcohol by adding an alkoxide to a compound having the structure, VII: The invention further relates to compounds having the structure I, IV, and VII and methods of making them therefor. The invention further relates to alcohols, and in particular, alcohols that are synthetic precursors to Taxol and analogs thereof.

US Patent:

6583292, Jun 24, 2003

Filed:

Feb 6, 2002

Appl. No.:

10/068645

Inventors:

Dennis C. Liotta - McDonough GA
Hariharan Venkatesan - Atlanta GA
Laura Captain - Durham NC
Michael V. Voronkov - Gainseville FL
James P. Snyder - Atlanta GA
Marcus A. Schestopol - Atlanta GA

Assignee:

Emory University - Atlanta GA

International Classification:

C07D26308

US Classification:

548237, 548239, 549510

Abstract:

Described herein is a method for preparing an ester by (a) admixing a compound having the formula I: with a base to form an intermediate, and (b) admixing the intermediate produced in step (a) with a compound composed of an alcohol, an alkoxide, or a combination thereof, wherein steps (a) and (b) are performed in situ.

US Patent:

6777441, Aug 17, 2004

Filed:

Oct 2, 2001

Appl. No.:

09/970089

Inventors:

Susheng Wang - Clarkston GA
Dennis C. Liotta - Atlanta GA
James P. Snyder - Atlanta GA
Hariharan Venkatesan - San Diego CA

Assignee:

Emory University - Atlanta GA

International Classification:

C07D31172

US Classification:

514475, 549336

Abstract:

The present invention provides synthetic methods and compositions for treatment of autoimmune and anti-inflammatory disorders comprising administering an effective amount of a derivative of triptolide alone or in combination or alternation with other anti-autoimmune or anti-inflammatory compounds.

US Patent:

7202269, Apr 10, 2007

Filed:

Oct 28, 2004

Appl. No.:

10/976067

Inventors:

Tristin K. Barclay - Denver CO, US
Alejandro Santillán, Jr. - San Diego CA, US
Liu Y. Tang - San Diego CA, US
Hariharan Venkatesan - San Diego CA, US
Ronald L. Wolin - San Diego CA, US

Assignee:

Janssen Pharmaceutica N.V.

International Classification:

A61K 31/40
A61K 31/17
C07D 207/06
C07C 335/18

US Classification:

514428, 514586, 548568, 564 27

Abstract:

Certain α-, β-, and γ-amino acid derivatives are disclosed as selective GlyT2 inhibitors for the treatment of central nervous system (CNS) conditions such as muscle spasticity, tinnitus, epilepsy and neuropathic pain.

US Patent:

7297816, Nov 20, 2007

Filed:

Sep 19, 2005

Appl. No.:

11/230249

Inventors:

Brett Allison - Del Mar CA, US
Victor K. Phuong - San Diego CA, US
Marna C. W. Pippel - Del Mar CA, US
Michael H. Rabinowitz - San Diego CA, US
Hariharan Venkatesan - San Diego CA, US

Assignee:

Janssen Pharmaceutica N.V. - Beerse

International Classification:

C07C 303/00
C07C 307/00
C07C 309/00
C07C 311/00

US Classification:

564 80, 558410

Abstract:

Certain sulfonamide compounds are dual CCK1/CCK2 inhibitors useful in the treatment of CCK1/CCK2 mediated diseases.

US Patent:

7557139, Jul 7, 2009

Filed:

Aug 17, 2004

Appl. No.:

10/919824

Inventors:

Hariharan Venkatesan - San Diego CA, US
James P. Snyder - Atlanta GA, US
Dennis C. Liotta - Atlanta GA, US
Susheng Wang - Clarkston GA, US

Assignee:

Emory University - Atlanta GA

International Classification:

A01N 43/20
A01N 45/00

US Classification:

514475, 549336

Abstract:

The present invention provides synthetic methods and compositions for treatment of autoimmune and anti-inflammatory disorders comprising administering an effective amount of a derivative of triptolide alone or in combination or alternation with other anti-autoimmune or anti-inflammatory compounds.

US Patent:

7842810, Nov 30, 2010

Filed:

Mar 30, 2006

Appl. No.:

11/393558

Inventors:

Brett D. Allison - Del Mar CA, US
Laurent Gomez - San Diego CA, US
Cheryl A. Grice - Carlsbad CA, US
Michael D. Hack - San Diego CA, US
Alejandro Santillan, Jr. - San Diego CA, US
Kimberly L. Schwarz - San Diego CA, US
Liu Y. Tang - San Diego CA, US
Hariharan Venkatesan - San Diego CA, US
John J. M. Wiener - La Jolla CA, US

Assignee:

Janssen Pharmaceutica, NV - Beerse

International Classification:

C07D 215/00

US Classification:

546153

Abstract:

Antibacterial compounds, compositions containing them, and methods of use for the inhibition of bacterial activity and the treatment, prevention or inhibition of bacterial infection.

US Patent:

7855292, Dec 21, 2010

Filed:

Nov 20, 2007

Appl. No.:

11/943520

Inventors:

Brett Allison - Del Mar CA, US
Victor K. Phuong - San Diego CA, US
Marna C. W. Pippel - Del Mar CA, US
Michael H. Rabinowitz - San Diego CA, US
Hariharan Venkatesan - San Diego CA, US

Assignee:

Janssen Pharmaceutica NV - Beerse

International Classification:

C07D 241/36

US Classification:

544353, 514361, 514249, 548127

Abstract:

Certain sulfonamide compounds are dual CCK1/CCK2 inhibitors useful in the treatment of CCK1/CCK2 mediated diseases.