Hardwin O O'Dowd from Cambridge, MA, age 51

Us Patents

Lincomycin Derivatives Possessing Antimicrobial Activity
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US Patent:

7199106, Apr 3, 2007
Filed:

Jun 17, 2004
Appl. No.:

10/871618
Inventors:

Jason G. Lewis - Hayward CA, US
Hardwin O'Dowd - Hayward CA, US
Mikhail F. Gordeev - Castro Valley CA, US
Assignee:

Vicuron Pharmaceuticals, Inc. - King of Prussia PA
International Classification:

A61K 31/70
C07H 15/16
C07H 17/04
US Classification:

514 24, 536 161, 536 162, 536 163, 536 164, 536 165
Abstract:

Novel lincomycin derivatives are disclosed. These lincomycin derivatives exhibit antibacterial activity. The compounds of the subject invention may exhibit potent activities against bacteria, including gram positive organisms, and may be useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.

Lincomycin Derivatives Possessing Antibacterial Activity
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US Patent:

7256177, Aug 14, 2007
Filed:

Nov 17, 2004
Appl. No.:

10/992564
Inventors:

Jason G. Lewis - Hayward CA, US
Sampath K. Anandan - Fremont CA, US
Hardwin O'Dowd - Hayward CA, US
Mikhail F. Gordeev - Castro Valley CA, US
Assignee:

Vicuron Pharmaceuticals, Inc. - King of Prussia PA
International Classification:

A61K 31/70
C07H 15/16
C07H 17/04
US Classification:

514 24, 536 161, 536 162, 536 163, 536 164, 536 165
Abstract:

Novel lincomycin derivatives are disclosed. These lincomycin derivatives exhibit antibacterial activity. The compounds of the subject invention may exhibit potent activities against bacteria, including Gram positive organisms, and may be useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.

N-Hydroxyamide Derivatives Possessing Antibacterial Activity
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US Patent:

7691843, Apr 6, 2010
Filed:

Jul 11, 2003
Appl. No.:

10/617616
Inventors:

Bore G. Raju - Fremont CA, US
Hardwin O'Dowd - Hayward CA, US
Hongwu Gao - Union City CA, US
Dinesh V. Patel - Fremont CA, US
Jaoquim Trias - Millbrae CA, US
Assignee:

Pfizer Inc. - New York NY
International Classification:

A61K 31/397
C07D 205/00
US Classification:

51421017, 548950
Abstract:

Novel N-hydroxyamide derivatives are disclosed. These N-hydroxyamide derivatives inhibit UPD-3-O—(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase, an enzyme present in gram negative bacteria and are therefore useful as antimicrobials and antibiotics. Methods of synthesis and of use of the compounds are also disclosed.

Isoindolinone Inhibitors Of Phosphatidylinositol 3-Kinase
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US Patent:

8466288, Jun 18, 2013
Filed:

Jan 13, 2012
Appl. No.:

13/349868
Inventors:

Alex Aronov - Newton MA, US
Jon H. Come - Cambridge MA, US
Robert J. Davies - Arlington MA, US
Albert Charles Pierce - Cambridge MA, US
Philip N. Collier - Cambridge MA, US
Hardwin O'Dowd - Boston MA, US
James A. Henderson - Cambridge MA, US
Elaine B. Krueger - Milton MA, US
Arnaud Le Tiran - Crossy sur Seine, FR
Yusheng Liao - Lexington MA, US
David Messersmith - Somerville MA, US
Jian Wang - Newton MA, US
Suganthini S. Nanthakumar - Newton MA, US
Jingrong Cao - Newton MA, US
Upul Keerthi Bandarage - Lexington MA, US
Anne-Laure Grillot - Milton MA, US
Assignee:

Vertex Pharmaceuticals Incorporated - Cambridge MA
International Classification:

C07D 471/02
C07D 213/04
C07D 401/00
C07D 401/02
C12N 9/99
A61K 31/437
US Classification:

546113, 546 15, 5462754, 546 18, 435184, 51421021, 514300
Abstract:

The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3Kγ. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

Gyrase And Topoisomerase Iv Inhibitors
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US Patent:

8481551, Jul 9, 2013
Filed:

Jan 13, 2012
Appl. No.:

13/349789
Inventors:

Arnaud Le Tiran - Croissy sur Seine, FR
Anne-Laure Grillot - Milton MA, US
Paul S. Charifson - Framingham MA, US
Yousef Laafiret Bennani - Lorraine, CA
Hardwin O'Dowd - Boston MA, US
Emanuele Perola - Brookline MA, US
Assignee:

Vertex Pharmaceuticals Incorporated - Cambridge MA
International Classification:

A01N 43/54
C07D 239/42
C07D 471/04
US Classification:

514256, 544333
Abstract:

The present invention relates to a compound of formula (I).

Lincomycin Derivatives Possessing Antibacterial Activity
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US Patent:

7361743, Apr 22, 2008
Filed:

Aug 31, 2005
Appl. No.:

11/217836
Inventors:

Jason G. Lewis - Castro Valley CA, US
Sampath K Anandan - Fremont CA, US
Hardwin O'Dowd - Hayward CA, US
Mikhail F Gordeev - Castro Valley CA, US
Liansheng Li - San Diego CA, US
Assignee:

Pfizer Inc - New York NY
International Classification:

C07H 15/16
US Classification:

536 163, 536 162, 536 165
Abstract:

Novel lincomycin derivatives are disclosed. These lincomycin derivatives exhibit antibacterial activity. The compounds of the subject invention may exhibit potent activities against bacteria, including Gram positive organisms, and may be useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.

Ramoplanin Derivatives Possessing Antibacterial Activity
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US Patent:

20060211603, Sep 21, 2006
Filed:

Aug 4, 2005
Appl. No.:

11/198763
Inventors:

Bore Raju - Fremont CA, US
Romeo Ciabatti - Novate Milanese, IT
Sonia Maffioli - Milano, IT
Upinder Singh - Fremont CA, US
Gabriella Romano - Legnano, IT
Elena Michelucci - Legnano, IT
Paolo Tiseni - Milano, IT
Gianpaolo Candiani - Gorgonzola, IT
Bum Kim - Union City CA, US
Hardwin O'Dowd - Hayward CA, US
Assignee:

VICURON PHARMACEUTICALS INC. - King of Prussia PA
International Classification:

A61K 38/14
C07K 9/00
C07K 7/64
A61K 38/12
US Classification:

514008000, 514009000, 530317000
Abstract:

Novel ramoplanin derivatives are disclosed. These ramoplanin derivatives exhibit antibacterial activity. As the compounds of the subject invention exhibit potent activities against gram positive bacteria, they are useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.

Isoindolinone Inhibitors Of Phosphatidylinositol 3-Kinase
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US Patent:

20120040950, Feb 16, 2012
Filed:

Dec 21, 2010
Appl. No.:

12/974388
Inventors:

Alex Aronov - Newton MA, US
Jon H. Come - Cambridge MA, US
Robert J. Davies - Watertown MA, US
Albert Charles Pierce - Cambridge MA, US
Philip N. Collier - Cambridge MA, US
Hardwin O'Dowd - Boston MA, US
James A. Henderson - Cambridge MA, US
Elaine B. Krueger - Milton MA, US
Arnaud Le Tiran - Croissy sur Seine, FR
Yusheng Liao - Lexington MA, US
David Messersmith - Somerville MA, US
Jian Wang - Newton MA, US
Suganthini S. Nanthakumar - Newton MA, US
Jingrong Cao - Newton MA, US
Upul Keerthi Bandarage - Lexington MA, US
Anne-Laure Grillot - Somerville MA, US
Assignee:

VERTEX PHARMACEUTICALS INCORPORATED - Cambridge MA
International Classification:

A61K 31/4439
C07D 401/14
A61K 31/444
C07D 471/04
A61K 31/437
C07D 403/14
A61K 31/506
C07D 413/14
A61K 31/5377
A61P 37/00
A61P 29/00
A61P 25/00
A61P 25/08
A61P 25/16
A61P 25/28
A61P 25/14
C12N 9/99
C07D 401/10
US Classification:

51421018, 5462771, 514339, 5462754, 5462724, 546256, 514333, 546113, 514300, 544310, 514274, 544127, 5142345, 51421021, 540575, 435184
Abstract:

The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3Kγ. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

Resumes

Hardwin O'dowd

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Location:

Boston, MA

Industry:

Pharmaceuticals

Skills:

Lc Ms
Organic Synthesis
Medicinal Chemistry
Organic Chemistry
Hplc
Chromatography
Drug Discovery
Lead Change
Drug Design
Nmr
Small Molecules
Medicine
Purification
Biotechnology
Chemistry
Drug Development
Pharmaceutical Industry
Synthetic Organic Chemistry