Handley E Jackson

US Patent:

7351867, Apr 1, 2008

Filed:

Feb 24, 2005

Appl. No.:

11/065222

Inventors:

Setrak K. Tanielyan - Maplewood NJ, US
Robert L. Augustine - Livingston NJ, US
Indra Prakash - Alpharetta GA, US
Kenneth E. Furlong - Evans GA, US
Handley E. Jackson - North Augusta SC, US

Assignee:

The NutraSweet Company - Chicago IL

International Classification:

C07C 45/00

US Classification:

568320, 568391, 568472

Abstract:

The present invention relates to a process of oxidation of alcohols selectively to aldehydes or ketones with molecular oxygen using a TEMPO based catalyst, Fe-bipyridyl or Fe-phenantroline co-catalyst and N-bromosuccinimide promoter in acetic acid solvent. The oxidation takes places at high rates and high aldehyde selectivity at temperatures in the range 45-50 C. and oxygen or air pressures of 0-15 psi. The alcohol conversion of 95-100% and aldehyde selectivity higher than 95% are achieved over 3-4 hours reaction time. Aldehydes such as 3,3-dimethyl-1-butanal can be produced efficiently using the present invention.

US Patent:

20040236140, Nov 25, 2004

Filed:

Apr 30, 2004

Appl. No.:

10/834933

Inventors:

Indra Prakash - Hoffman Estates IL, US
Kenneth Furlong - Evans GA, US
Handley Jackson - North Augusta SC, US

Assignee:

NUTRASWEET COMPANY - CHICAGO IL

International Classification:

C07K005/04

US Classification:

560/040000

Abstract:

N-[N-(3,3-dimethylbutyl)-L--aspartyl]-L-phenylalanine 1-methyl ester is produced by hydrogenation of L--aspartyl-L-phenylalanine 1-methyl ester and 3,3-dimethylbutyraldehyde produced in situ by the hydrolysis or cleavage of a 3,3-dimethylbutyraldehyde precursor. The production method is efficient and low cost, as compared with conventional N-[N-(3,3-dimethylbutyl)-L--aspartyl]-L-phenylalanine 1-methyl ester synthesis.

US Patent:

20080045744, Feb 21, 2008

Filed:

Sep 19, 2007

Appl. No.:

11/857781

Inventors:

INDRA PRAKASH - HOFFMAN ESTATES IL, US
KENNETH FURLONG - EVANS GA, US
HANDLEY JACKSON - NORTH AUGUSTA SC, US

Assignee:

THE NUTRASWEET COMPANY - Chicago IL

International Classification:

C07C 233/17

US Classification:

560169000

Abstract:

N—[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester is produced by hydrogenation of L-α-aspartyl-L-phenylalanine 1-methyl ester and 3,3-dimethylbutyraldehyde produced in situ by the hydrolysis or cleavage of a 3,3-dimethylbutyraldehyde precursor. The production method is efficient and low cost, as compared with conventional N—[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester synthesis.

US Patent:

6825384, Nov 30, 2004

Filed:

Jan 29, 2004

Appl. No.:

10/767805

Inventors:

Indra Prakash - Hoffman Estates IL
Setrak K. Tanielyan - Maplewood NJ
Robert L. Augustine - Livingston NJ
Kenneth E. Furlong - Evans GA
Robert C. Scherm - Evans GA
Handley E. Jackson - North Augusta SC

Assignee:

The NutraSweet Company - Chicago IL

International Classification:

C07C 4529

US Classification:

568402, 568407, 568471, 568472

Abstract:

The present invention relates to a process of oxidation of alcohols selectively to aldehydes or ketones with NaOCl using a TEMPOâborate catalyst system. It is shown that the oxidation can be efficiently carried out without KBr additives under solvent free conditions. Aldehydes such as 3,3-dimethylbutyraldehyde can be produced efficiently using the present invention.