Hamish A Mcarthur from 202 Library St, Mystic, CT 06355, age 74, Phone: 860 536-7245

Methods Related To Streptomyces Avermitilis Gene Directing The Ratio Of B2:B1 Avermectins
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US Patent:

6509159, Jan 21, 2003
Filed:

Jan 22, 2001
Appl. No.:

09/766916
Inventors:

Hamish McArthur - Gales Ferry CT
Yoshihiro Katoh - Aichi, JP
Assignee:

Pfizer Inc. - New York NY
Pfizer Products Inc. - Groton CT
International Classification:

C12Q 168
US Classification:

435 6, 435 76
Abstract:

The present invention relates to polynucleotide molecules comprising nucleotide sequences encoding the aveC gene product, which polynucleotide molecules can be used to alter the ratio or amount of class 2:1 avermectins produced in fermentation cultures of The present invention further relates to vectors, host cells, and mutant strains of in which the aveC gene has been inactivated, or mutated so as to change the ratio or amount of class 2:1 avermectins produced.

Streptomyces Avermitilis Gene Directing The Ratio Of B2:B1 Avermectins
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US Patent:

6511841, Jan 28, 2003
Filed:

Jan 22, 2001
Appl. No.:

09/766898
Inventors:

Hamish McArthur - Gales Ferry CT
Yoshihiro Katoh - Aichi, JP
Assignee:

Pfizer, Inc. - New York NY
Pfizer Products, Inc. - Groton CT
International Classification:

C12N 120
US Classification:

4352535, 435119, 435 76, 435 75, 435 701, 4353201, 4352523, 43525235, 435440, 435471, 435476, 435486, 536 71, 536 231, 536 237, 536 2374, 530350
Abstract:

The present invention relates to polynucleotide molecules comprising nucleotide sequences encoding an aveC gene product, which polynucleotide molecules can be used to alter the ratio or amount of class 2:1 avermectins produced in fermentation cultures of. The present invention further relates to vectors, host cells, and mutant strains of in which the aveC gene has been inactivated, or mutated so as to change the ratio or amount of class 2:1 avermectins produced.

13-Methyl Erythromycin Derivatives
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US Patent:

6777543, Aug 17, 2004
Filed:

May 19, 2003
Appl. No.:

10/441347
Inventors:

Yong-Jin Wu - Madison CT
Wei-Guo Su - East Lyme CT
Takushi Kaneko - Guilford CT
Hamish McArthur - Mystic CT
Assignee:

Pfizer, Inc. - New York NY
International Classification:

C07H 1708
US Classification:

536 74, 536 72, 536 73
Abstract:

The invention relates to compounds of the formula and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R , R , R , R , R , R , R , A, X, and Y are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formulas 1, methods of using the compounds of formula 1 in the treatment of infections and methods of preparing the compounds of formula 1.

Avec Gene Product From Streptomyces Hygroscopicus
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US Patent:

6833263, Dec 21, 2004
Filed:

Nov 27, 2002
Appl. No.:

10/306249
Inventors:

Hamish McArthur - Gales Ferry CT
Yoshihiro Katoh - Aichi, JP
Assignee:

Pfizer Inc. - New York NY
International Classification:

C12N 988
US Classification:

435232, 530350
Abstract:

The present invention relates to polynucleotide molecules comprising sequences encoding avec gene products, which polynucleotide molecules can be used to alter the ratio or amount of class 2:1 avermectins produced in fermentation cultures of. AveC genes, homologs and partial homologs thereof are described for , S. hygroscopicus, and , respectively. The present invention further relates to vectors, host cells, and mutant strains of in which the avec gene has been inactivated, or mutated so as to change the ratio or amount of class 2:1 avermectins produced.

Methods Related To Gene Directing The Ratio Of B2:B1 Avermectins
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US Patent:

7029887, Apr 18, 2006
Filed:

Nov 27, 2002
Appl. No.:

10/306247
Inventors:

Hamish McArthur - Gales Ferry CT, US
Yoshihiro Katoh - Aichi, JP
Assignee:

Pfizer Inc. - New York NY
International Classification:

C12N 9/00
US Classification:

435183, 4353201, 4352523, 43525411, 435419, 435325, 536 231, 536 232
Abstract:

The present invention relates to polynucleotide molecules comprising sequences encoding avec gene products, which polynucleotide molecules can be used to alter the ratio or amount of class 2:1 avermectins produced in fermentation cultures of. AveC genes, homologs and partial homologs thereof are described for , and , respectively. The present invention further relates to vectors, host cells, and mutant strains of in which the avec gene has been inactivated, or mutated so as to change the ratio or amount of class 2:1 avermectins produced.

13-Methyl Erythromycin Derivatives
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US Patent:

20030100518, May 29, 2003
Filed:

May 24, 2000
Appl. No.:

09/577901
Inventors:

Yong-Jin Wu - Madison CT, US
Wei-Guo Su - East Lyme CT, US
Takushi Kaneko - Guilford CT, US
Hamish Mcarthur - Mystic CT, US
International Classification:

A61K031/7048
A61K031/7052
C07H017/08
US Classification:

514/029000, 536/007100
Abstract:

The invention relates to compounds of the formula and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R, R, R, R, R, R, R, A, X, and Y are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formulas 1, methods of using the compounds of formula 1 in the treatment of infections and methods of preparing the compounds of formula 1.

Compositions Related To Streptomyces Avermitilis Gene Directing The Ratio Of B2:B1 Avermectins
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US Patent:

20030129635, Jul 10, 2003
Filed:

Nov 27, 2002
Appl. No.:

10/306246
Inventors:

Hamish McArthur - Gales Ferry CT, US
Yoshihiro Katoh - Aichi, JP
International Classification:

C12Q001/68
C07H021/04
C12P021/02
C12N001/21
C12N009/00
C12N015/74
US Classification:

435/006000, 435/069100, 435/183000, 435/320100, 435/252300, 536/023200
Abstract:

The present invention relates to polynucleotide molecules comprising nucleotide sequences encoding an aveC gene product, which polynucleotide molecules can be used to alter the ratio or amount of class 2:1 avermectins produced in fermentation cultures of The present invention further relates to vectors, host cells, and mutant strains of in which the aveC gene has been inactivated, or mutated so as to change the ratio or amount of class 2:1 avermectins produced.

Streptomyces Avermitilis Gene Directing The Ratio Of B2:B1 Avermectins
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US Patent:

20030134313, Jul 17, 2003
Filed:

Nov 27, 2002
Appl. No.:

10/306013
Inventors:

Hamish McArthur - Gales Ferry CT, US
Yoshihiro Katoh - Aichi, JP
International Classification:

C12Q001/68
C07H021/04
C12N009/00
C12N001/21
C12P021/02
C12N015/74
US Classification:

435/006000, 435/069100, 435/183000, 435/252300, 435/320100, 536/023200
Abstract:

The present invention relates to polynucleotide molecules comprising nucleotide sequences encoding an aveC gene product, which polynucleotide molecules can be used to alter the ratio or amount of class 2:1 avermectins produced in fermentation cultures of The present invention further relates to vectors, host cells, and mutant strains of in which the aveC gene has been inactivated, or mutated so as to change the ratio or amount of class 2:1 avermectins produced.

Hamish A Mcarthur