Haifan Wu

US Patent:

20170232055, Aug 17, 2017

Filed:

Feb 22, 2017

Appl. No.:

15/438932

Inventors:

Jianfeng Cai - Tampa FL, US
Chuanhai Cao - Temple Terrace FL, US
Haifan Wu - Tampa FL, US
Yaqiong Li - Tampa FL, US
Ge Bai - Tampa FL, US

Assignee:

UNIVERSITY OF SOUTH FLORIDA - Tampa FL

International Classification:

A61K 38/07

Abstract:

Embodiments of the present disclosure provide for γ-AApeptides, γ-AApeptide building blocks, methods of making γ-AApeptides and libraries of γ-AApeptides, methods of screening the γ-AApeptide libraries for desired peptidomimetic activity, and the like. The present disclosure also provides for γ-AApeptides that are inhibitors of Aβ peptide aggregation, methods of inhibiting and disassembling Aβ peptide aggregation, methods of inhibiting the toxicity of Aβ aggregates towards N2a neuroblasotma cells, as well as methods and compounds for treating Alzheimer's disease.

US Patent:

20170058002, Mar 2, 2017

Filed:

Oct 13, 2016

Appl. No.:

15/292162

Inventors:

JIANFENG CAI - TAMPA FL, US
YOUHONG NIU - TAMPA FL, US
HAIFAN WU - TAMPA FL, US
SHRUTI PADHEE - TAMPA FL, US

Assignee:

UNIVERSITY OF SOUTH FLORIDA - TAMPA FL

International Classification:

C07K 7/56
A61K 47/48
C07K 1/10
C07K 7/06
C07K 1/16

Abstract:

The present invention is directed to a novel class of antimicrobial agents called γ-AApeptides. The current invention provides various categories of γ-AApeptides, for example, linear γ-AApeptides, cyclic γ-AApeptides, and lipidated γ-AApeptides. γ-AApeptides of the current invention are designed to exert antimicrobial activity while being stable and non-toxic. γ-AApeptides also do not appear to lead to the development of microbial resistance in treated microorganisms. Thus, the disclosed γ-AApeptides can be used for the treatment of various medical conditions associated with pathogenic microorganisms.

US Patent:

20160209422, Jul 21, 2016

Filed:

Aug 18, 2014

Appl. No.:

14/914960

Inventors:

Jianfeng CAI - Tampa FL, US
Chuanhai CAO - Temple Terrace FL, US
Haifan WU - Tampa FL, US
Yaqiong LI - Tampa FL, US
Ge BAI - Tampa FL, US

Assignee:

UNIVERSITY OF SOUTH FLORIDA - Tampa FL

International Classification:

G01N 33/68
B01J 19/00
C07K 5/02

Abstract:

Embodiments of the present disclosure provide for γ-AApeptides, γ-AApeptide building blocks, methods of making γ-AApeptides and libraries of γ-AApeptides, methods of screening the γ-AApeptide libraries for desired peptidomimetic activity, and the like. The present disclosure also provides for γ-AApeptides that are inhibitors of Aβ peptide aggregation, methods of inhibiting and disassembling Aβ peptide aggregation, methods of inhibiting the toxicity of Aβ aggregates towards N2a neuroblasotma cells, as well as methods and compounds for treating Alzheimer's disease.

US Patent:

20150274782, Oct 1, 2015

Filed:

Jan 23, 2013

Appl. No.:

14/374018

Inventors:

Jianfeng Cai - Tampa FL, US
Youhong Niu - Tampa FL, US
Haifan Wu - Tampa FL, US
Shruti Padhee - Tampa FL, US

Assignee:

UNIVERSITY OF SOUTH FLORIDA - TAMPA FL

International Classification:

C07K 7/64
A61K 45/06
A61K 49/00
C07K 7/06

Abstract:

The present invention is directed to a novel class of antimicrobial agents called γ-AApeptides. The current invention provides various categories of γ-AApeptides, for example, linear γ-AApeptides, cyclic γ-AApeptides, and lipidated γ-AApeptides. γ-AApeptides of the current invention are designed to exert antimicrobial activity while being stable and non-toxic. γ-AApeptides also do not appear to lead to the development of microbial resistance in treated microorganisms. Thus, the disclosed γ-AApeptides can be used for the treatment of various medical conditions associated with pathogenic microorganisms.